On June 21,2006, a destructive Ms5. 0 earthquake occurred at Wenxian, Gansu province, which caused damage to buildings and casualties. In the investigation of seismic field and assessment of earthquake disaster after the event, the disaster area is divided into 2 parts, and the investigation work for 29 sampling spots are finished. According to the loss assessment system of seismic disaster EDLES2.5, a database is set up, and a relatively practical assessment of economic loss is done. Finally, some advices for restoration in earthquake area are put forward.