In order to understand the characteristics of frame building grounding resistance affected by seasons and weather process, this paper analyzes the grounding resistance and the related meteorological elements from automatic weather observation in 2010 in Conghua, Guangzhou. According to the characteristics of seasons variation, minimum grounding resistance is 0.57 Ω in Sep., while the maximum is 0.78 Ω in Feb. and the annual variation maximum value is about 0.21 Ω, which means the grounding resistance of frame building is relatively stable. Based on the seasonal variation curve and rainstorm process, a negative correlation among grounding resistance, 1.5 m soil temperature and 1.0m soil moisture is found out. The reduction value of grounding resistance has no obvious correlation with rainstorm intensity. An analysis on a long-time draught is also made in this paper, whose result shows that the grounding resistance has an upward trend, especially in summer.