The southeastern Tibetan Plateau is an ideal place to study the interactions among tectonics, geomorphic evolution and climate. Previous studies have mainly revealed two rapid exhumation phases during late Eocene- early Miocene and late Miocene to present, but the evolution process during Late Cretaceous- Early Cenozoic remain unclear. The Cilincuo granite with entire Cenozoic thermochronology data provide important reference for exploring the exhumation evolution history during the early Cenozoic in SE Tibet. However, the cooling event of Cilincuo granite during Early Cenozoic, resulting from magma cooling or rapid exhumation, remains questionable, which needs studying quantitatively. In this study, we review published chronological data, and use zircon saturation thermometers and 1- D magma cooling modelling to constrain the crystallization temperature, minimum emplacement depth and minimum exhumation amount of the Cilincuo granite during the Late Cretaceous- Early Cenozoic. The results of zircon saturation temperatures for Cilincuo granite suggest that the magma crystallization temperature of Cilincuo granite is between 647℃ and 705℃, belonging to low temperature granite. 1- D magma cooling modelling results suggest that the minimum surrounding rock temperature is 160~120℃, and the corresponding depth is about 3.7~5.0 km. Combining zircon and apatite (U- Th)/He thermochronology data, we suggest that the intrusion experienced a rapid exhumation event of at least 2 km during the Late Cretaceous- Early Cenozoic (67~40 Ma). Our results combined with prevoious published results suggest that this rapid exhumation phase may be a widespread tectonic exhumation event in the Tibetan Plateau, which is probably triggered by the subduction and closure of the New Tethys ocean and the initial collision of the Indo- Asian plate.