The Caledonian paleo- uplift in the Sichuan Basin is located in the mid- west of basin, adjacent to the east of the Longmen mountain tectonic belt. Analysis of the formation and evolution of the Caledonian paleo- uplift and the dynamics of its genetic mechanism is of great significance for studying intraplate tectonic deformation and guiding oil and gas exploration. To achieve this, guided by the results of previous studies, we have undertaken new research using a large number of seismic reflection profiles and drilling data. In this study, by comparing and analyzing the stratigraphic correlation in different regions, we have determined the absence of Pre- Permian strata in the paleo- uplift area, as well as the distribution range of pinching point, unconformity truncation point, and onlap point in different strata. Based on these we provide a detailed description of the distribution characteristic of Caledonian paleo- uplift by using a combination of seismic profiles and cross well lines, thus revealing the periodic evolutionary characteristic of the Caledonian paleo- uplift. By researching the paleo- structural evolution of the Dengying Formation and combining it with the balanced section technique, we have divided the formation and evolution stages of the paleo- uplifts into five stages, namely, the embryonic stage (Z), the developmental stage (∈~S), the denudation and flattening stage (D~C), the stable burial stage (P~T2l) and the finalization stage (T3x~Current). Based on these results, we have further investigated the genetic mechanism of the Caledonian paleo- uplift, and revealed its evolutionary characteristics by taking into account the tectonic background and characteristics of the basement faults in the Sichuan Basin. It is mainly believed that the formation of Caledonian paleo- uplift is controlled by the regional tectonic movement and the segmental activities of basement faults. The differtial uplift, similar to the “grabenhorst” in the basement, resulted in a “great uplift to big depression” tectonic pattern in the basin, which in turn influenced the formation and evolution of the inherited paleo- uplift.