Abstract: The uplift or denudation is shown as a progressive process from north to south in the eastern margin area of the Tibetan Plateau during the Meso­Cenozoic by the low­temperature thermochronological data(31 ZFT samples,56 AFT samples and 37 A(U­Th)/He samples). The uplift rates are remarkably different between the Danba Arc Belt and the Maowen Arc Belt. The Maowen Arc Belt was uplifted earlier than the Danba Arc Belt，and its rate of uplift and denudation was firstly high(110Ma)but became lower later(10Ma). The Danba Arc Belt was uplifted later. Its rate of uplift and denudation decreased remarkably in the Early Miocene and kept stable for a period.But it uplifted and denudated much faster after Early Miocene. It is indicated that the age of uplift(or rate of denudation)gradually became older(or lower)from the South to the North or from SE to NW in the region，which has the typical character of arc framework in shallow layer(70℃ isoclines). Therefore，the process of uplift in the eastern margin area of the Tibetan Plateau is strongly influenced by the formation and evolution of Central Orogenic Belt and Tibetan Plateau，and has been intensively controlled by the arc framework in shallow layer.