| CT肺气肿容积及小阴影密集度与尘肺肺功能相关性的研究 |
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| 引用本文： | 赵琪琪,冯莉,刘玉全,王梅芳.CT肺气肿容积及小阴影密集度与尘肺肺功能相关性的研究[J].CT理论与应用研究,2023,32(1):121-129. |
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| 作者姓名： | 赵琪琪 冯莉 刘玉全 王梅芳 |
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| 作者单位： | 1.锦州医科大学十堰市太和医院研究生培养基地, 湖北 十堰442000 |
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| 摘 要： | 目的：比较尘肺患者肺气肿程度及肺部小阴影对肺功能的影响。方法：选择2015年至2020年间十堰市太和医院收治的明确诊断尘肺且合并肺气肿的患者96名，进行胸部CT检查及肺功能测定；采用64排螺旋CT(GE Optima CT 680)进行三维容量测量系统定量分析全肺、左右肺、各肺上中下肺野低衰减区容积百分比（LAV%），并根据全肺LAV%将其分为A组：LAV%<15%,B组：LAV%15%～30%,C组：LAV%> 30%三组，分析肺气肿分布特点及与肺功能的相关性；将胸片评定小阴影密集度的标准应用于CT中得出CT图像的全肺、左右肺、上中下肺野小阴影密集度（SSD），并分析与肺功能的相关性。结果：全肺SSD与FEV1、TLC、PEF、MEF75%、MEF25%呈负相关，与RV/TLC呈正相关；全肺、左肺、右肺、及上中下肺野LAV%与FEV1、FEV1%、DLCO、PEF、MEF75%、MEF50%、MEF25%呈负相关，与RV、RV/TLC%呈正相关；当LAV%> 30%时，即C组LAV%与肺功能FEV1、FEV1%、DLCO、RV/TLC、PEF、MEF75%、MEF5...
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| 关 键 词： | CT 尘肺 肺气肿 肺功能 |
| 收稿时间： | 2021-11-23 |
Correlation between Emphysema Volume and Small Shadow Density on CT and the Lung Function in Pneumoconiosis |
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| Affiliation: | 1.Postgraduate Training Basement of Jinzhou Medicial University, Taihe Hospital, Shiyan 442000, China1.Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China Department of General Medicine2.Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China Department of Respiratory and Critical Care Medicine |
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| Abstract: | Objective: To compare the influence of emphysema and lung small shadow on the lung function of patients with pneumoconiosis. Methods: We selected 96 patients who were admitted to the Taihe Hospital (Shiyan city) for pneumoconiosis complicated by emphysema between 2015 and 2020. Chest computed tomography (CT) and lung function assessments were performed. The low attenuation volumes (LAV%) of the whole lung; left and right lungs; and upper, middle, and lower lobes of each lung were quantified using 64-slice spiral CT (GE Optima CT680). Based on the LAV% of the whole lung, the patients were divided into groups A (LAV%<15%), B (LAV%: 15%–30%), and C (LAV% >30%). The small shadow density (SSD) of the whole lung; left and right lungs; and upper, middle, and lower lung fields was calculated by applying the criteria for evaluating SSD on chest radiographs to CT images. The correlation between SSD and lung function was also analyzed. Results: The SSD of the whole lung was negatively correlated with the forced expiratory volume in the first second (FEV1), total lung capacity (TLC), peak expiratory flow (PEF), maximum expiratory flow after 75% of the forced vital capacity (FVC) has not been exhaled (MEF75%), and maximum expiratory flow after 25% of the FVC has not been exhaled (MEF25%), and it was positively correlated with residual volume (RV)/TLC. LAV% was negatively correlated with FEV1, ratio of FEV to FEV1 (FEV1%), carbon monoxide diffusion capacity (DLCO), PEF, MEF75%, maximum expiratory flow after 50％ of the FVC has not been exhaled (MEF50%), and MEF25% in the whole lung; left and right lungs; and upper, middle, and lower lung lobes; however, it was positively correlated with RV and RV/TLC%. When LAV% was >30%, the correlation between LAV% and FEV1, FEV1%, DLCO, RV/TLC, PEF, MEF75%, MEF50%, and MEF25% was stronger in group C than in groups A and B. A certain degree of correlation was observed between the SSD in the lungs and the ventilation function and volume parameters; however, the correlation between SSD and the diffusion function was weak. Conclusion: The degree of emphysema and SSD in patients with pneumoconiosis have a certain degree of correlation with the lung function; however, the SSD of emphysema has a relatively better correlation with the lung function. It can be used to evaluate the degree of lung injury in patients with pneumoconiosis to a certain extent and is worthy of clinical application. |
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