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| 海洋红藻多管藻内生真菌EN-22 的化学成分研究 | |
| 引用本文： | 赵婷婷,李晓明,李景梅,李可,崔传明,李春顺,王斌贵.海洋红藻多管藻内生真菌EN-22 的化学成分研究[J].海洋科学,2009,33(7):81-86. |
| 作者姓名： | 赵婷婷 李晓明 李景梅 李可 崔传明 李春顺 王斌贵 |
| 作者单位： | 1. 中国科学院,海洋研究所,实验海洋生物学重点实验室,山东,青岛,266071;长春理工大学,吉林,长春,130022 2. 中国科学院,海洋研究所,实验海洋生物学重点实验室,山东,青岛,266071 3. 长春理工大学,吉林,长春,130022 |
| 基金项目： | 国家自然科学基金，山东省科技发展计划项目，中国科学院院长基金 |
| 摘 要： | 对采自广西涠州岛近海多管藻(Poiysiphonia urceolata)分离到的一株内生真菌EN-22的次生代谢产物的化学成分进行了研究.利用正相硅胶柱层析、葡聚糖凝胶Sephadex LH-20柱层析、制备薄层层析(PTLC)以及重结晶等分离手段从该菌发酵液中分离得到15个化合物,通过一维、二维核磁共振技术、质谱技术等鉴定了所有化合物的结构,分别为:4-(4-喹啉)-4-羟基-2-丁酮(1),3-羟基-3-(2-氧丙基)吲哚-2-酮(2),3-吲哚乙醇(3),3-吲哚甲酸(4),2-羟基-3-吲哚丙酸(5),2-酮-3-吲哚乙醇(6),3,3-二吲哚-2-羟基-丙醇(7),β-咔啉(8),尿嘧啶(9),环-(S-脯氨酸-S-异亮氨酸)(10),(22E,24R)-3β,5α,9α-三羟基麦角甾-7,22-二烯-6-酮(11),(22E,24R)-5α,6α-环氧麦角甾-8,22-二烯-3β,7α-二醇(12),5α,6α-环氧-24(R)-甲基胆甾-7,22-二烯-3β-醇(13),胡萝卜苷(14),过氧化麦角甾醇(15);其中化合物1和2为新天然产物,并首次报道化合物1的碳谱数据. |
| 关 键 词： | 多管藻(Polysiphonia urceolata) 内生真菌 化学成分 结构鉴定 |
| 收稿时间： | 2008/11/24 0:00:00 |
| 修稿时间： | 2009/3/10 0:00:00 |
Chemical constituents of EN-22, an endophytic fungus derived from the marine red alga Polysiphonia urceolata |
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| ZHAO Ting-ting,LI Xiao-ming,LI Jing-mei,LI Ke,CUI Chuan-ming,LI Chun-shun and WANG Bin-gui.Chemical constituents of EN-22, an endophytic fungus derived from the marine red alga Polysiphonia urceolata[J].Marine Sciences,2009,33(7):81-86. | |
| Authors: | ZHAO Ting-ting LI Xiao-ming LI Jing-mei LI Ke CUI Chuan-ming LI Chun-shun and WANG Bin-gui |
| Abstract: | From the fermentation culture of an endophytic fungus EN-22 that was derived from the marine red alga Polysiphonia urceolata, fifteen compounds were isolated by column chromatography separation on the normal phase silica gel and Sephadex LH-20, and by the preparative thin layer chromatography (PTLC) as well as by re-crystallization. Structures of all purified compounds were elucidated by analysis of their spectroscopic data including MS, 1D and 2D NMR to be 4-(4-Quinolyl)-4 hydroxy-2-butanone (1), 3-hydroxy-3-(2-oxopropyl)indo-lin-2-on (2), 2-(1H-indol-3-yl)ethanol (3), 1H-indole-3-carboxylic acid (4), 2-hydroxy-3-(1H-indol-3-yl)propanoic acid (5), 2-hydroxy-1-(1H-indol-3-yl)ethanone (6), 3,3-di(1H-indol-3-yl)propane-1,2-diol (7),β-carbolines (8), uracil (9), cyclo-(S-Pro-S-lle) (10), (22E,24R)-3β,5α,9α-trihydroxy-ergosta-7,22-diene-6-one (11), 22E,24R-Sα,6α-epoxyergosta-8,22-dien-3β,7a-diol (12), 5α,6α-epoxy-24(R)-methylcholesta-7,22-dien-3β-ol (13), daucosterol(14), and ergosterol peroxide (15). Compounds 1 and 2 were reported as new natural products. |
| Keywords: | Polysiphonia urceolata Endophytic fungus EN-22 chemical constituents structure elucidation |
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