| 喹诺酮类药物对牙鲆肝药物代谢酶活性的影响 |
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| 引用本文： | 韩 华,李 健,李吉涛,韩现芹,陈 萍.喹诺酮类药物对牙鲆肝药物代谢酶活性的影响[J].海洋科学,2009,33(11):48-54. |
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| 作者姓名： | 韩 华 李 健 李吉涛 韩现芹 陈 萍 |
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| 作者单位： | 1. 上海海洋大学,水产与生命学院,上海,201306;中国水产科学院,黄海水产研究所,农业部海洋渔业资源可持续利用重点开放实验室,山东,青岛,266071
2. 中国水产科学院,黄海水产研究所,农业部海洋渔业资源可持续利用重点开放实验室,山东,青岛,266071 |
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| 基金项目： | 科技部社会公益研究专项，公益性农业行业科研专项 |
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| 摘 要： | 以牙鲆(Paralichthys olivaceus)为研究对象,通过观察水产用的3种喹诺酮类药物(FQ)恩诺沙星、诺氟沙星和氟甲喹分别对牙鲆肝组织中氨基比林N-脱甲基酶(AND)、红霉素N-脱甲基酶(ERND)和7-乙氧基异吩唑酮-脱乙基酶(EROD)活性的影响,探讨喹诺酮类药物对牙鲆肝药物代谢酶(细胞色素P-450)活性影响的差异.结果表明,与对照组比较,三组喹诺酮类药物对牙鲆肝S_9中AMND、ERND、EROD酶活性均具有抑制作用,其中恩诺沙星和诺氟沙星组中,3种酶的活性极显著下降(P＜0.01),而对于氟甲喹组而言,AMND、ERND酶活性显著下降(P＜0.05),EROD酶活性极显著下降(P＜0.01).
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| 关 键 词： | 牙鲆(Paralichthys olivaceus) 细胞色素P450 喹诺酮类药物 |
| 收稿时间： | 2009/2/26 0:00:00 |
| 修稿时间： | 2009/5/16 0:00:00 |
Effects of quinolones on activity of hepatic drug metabolizing enzymes in Paralichthys olivaceus |
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| HAN Hu,LI Jian,Li Ji-tao,HAN Xian-qin and Chen Ping.Effects of quinolones on activity of hepatic drug metabolizing enzymes in Paralichthys olivaceus[J].Marine Sciences,2009,33(11):48-54. |
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| Authors: | HAN Hu LI Jian Li Ji-tao HAN Xian-qin and Chen Ping |
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| Abstract: | In order to observe the difference of effects of quinolones on the activity of drug-metabolism(cytochrome P-450),we studied the effects of quinolones(FQ)on the activities of APND,ERND and EROD in the liver of flounders(Paralichthys olivaceus).The results showed that the activities of APND,ERND and EROD in the S_9 mix were inhibited by the three kinds of quinolones on the different degrees,where enrofloxacin and norfloxacin treated groups had a very significant decrease on the activities of APND,ERND and EROD compared to the control group(P＜0.01),while flumequine treated group only decreased the activity of EROD very significantly(P＜0.01),and had a significant decrease on the activities of APND and ERND. |
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| Keywords: | Paralichthys olivaceus Cytochrome P450 enzymes quinolones |
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