Abstract: The significant achievements in past three-year of superimposed orogenesis and metallogenesis in the Sanjiang Tethys, the National 973-Program, are briefly summarized in this paper, including the metallogenic geodynamic setting, the metallogenic systems of accreting orogen and collisional orogen, the transition of tectonic regime and superimposed orogenesis, the metallogenic forecasting theory and the exploration techniques. (1) The metallogenic geodynamic setting of the proto-, paleo-, neo-Tethys and continental collision have been built up, and the large-scale tectonics-magmatism-metallogenic event during the Yanshanian has been proposed. (2) VMS Cu-Pb-Zn metallogenic systems have been divided into three types: the passive continental margin type, the active continental margin type, and ocean basin type. Studies showed that the metallogenesis in the Yulong and Xianggelila porphyry Cu metallogenic belt was related to the Indian magmatic activities. (3) Sediment-hosted Pb-Zn-Cu-Ag deposits formed at the three stages of the Indo-Asia collisional orogen, which include two metallogenic systems: the vein Cu systems are related to metamorphic fluids from both of the deep crust and shallow sedimentary strata, and Pb-Zn-Cu-Ag systems are related to basin fluids from the shallow sedimentary strata. (4) Porphyry Cu metallogenic system in the Jinshajiang-Ailaoshan belt formed in the age of 35Ma±, which is controlled by the crust thickness from the Indo-Asia collisional orogen. (5) Orogenic gold deposits occurred in three tectonic-thermal events: the earlier convergence regime of India-Eurasia at 62Ma±, and the transition of tectonic regime at the later stage of 35Ma± and 28Ma. (6) There have been occurred three stages of the transition of tectonic regime in the Sanjiang Tethys: from the accreting orogen to the collisional orogen, from the main collision to late collision, and from late collision to post-collision. The former two controlled the formation of porphyry Cu belts, sediment-hosted Pb-Zn-Cu-Ag belts, and orogenic gold belts. However, the latter controlled the formation of Pb-Zn deposits in the Tuotuohe basin. (7) Both VMS-type Cu-Pb-Zn and porphyry Cu systems are classical superimposed metallogenesis in the Sanjiang Tethys, which both occur in the Yangla-Hongshan-Pulang-Tongchanggou ore concentrating area, and Yunxian-Jinggu, Jiangda-Weixi and Changning-Menglian metallogenic belts. (8) In terms of the metallogenic forecasting theory and exploration techniques, the undiscovered mineral resources in the Yangla-Hongshan-Pulang-Tongchanggou ore concentrating area have been evaluated. This special issue has introduced the significant achievements from twenty eight papers including four aspects as follows: the metallogenic geodynamics background, metallogenic system of accreting orogen, metallogenic system of collisional orogen, transition of tectonic regime and superimposed orogenesis.