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Until recently, little was known about the fungi found in shark gills and their biomedicinal potential. In this article, we described the isolation, bioactivity, diversity, and secondary metabolites of bioactive fungi from the gill of a shark (Carcharodon carcharias). A total of 115 isolates were obtained and grown in 12 culture media. Fifty-eight of these isolates demonstrated significant activity in four antimicrobial, pesticidal, and cytotoxic bioassay models. Four randomly selected bioactive isolates inhibited human cancer cell proliferation during re-screening. These active isolates were segregated into 6 genera using the internal transcribed spacer-large subunit (ITS-LSU) rDNA-sequence BLAST comparison. Four genera, Penicillium, Aspergillus, Mucor, and Chaetomium were the dominant taxa. A phylogenic tree illustrated their intergenera and intragenera genetic diversity. HPLC-DAD-HRMS analysis and subsequent database searching revealed that nine representative strains produced diverse bioactive compound profiles. These results detail the broad range of bioactive fungi found in a shark’s gills, revealing their biopharmaceutical potential. To the best of our knowledge, this is the first study characterizing shark gill fungi and their bioactivity. 相似文献
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刘德镒 《国土资源导刊(湖南)》2008,5(3)
自然界矿物、岩石有3000多种,矿物名称很多．也很复杂。许多来地质博物馆参观的观众常会问及矿物名称的问题。其实矿物名称还是有章可循的,只要我们知道矿物的命名方法及一些矿物名称的来源,就对矿物的名称不难掌握了。 相似文献
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毛泽东同志曾经说过：＂学风和文风都是党的作用,都是党风。＂党风、政风决定着文风,反过来,文风又体现出党风、政风,并会深刻地影响着党风、政风。战争年代,著名的延安整风运动的一个重要内容,就是整顿文风。毛泽东同志对党八股深恶痛绝,号召全党摒弃党八股,倡导生动活泼、新鲜有力的新文风。他批评那种曾一度盛行于党内的不良文风,像老太太的裹脚布,又臭又长。反观毛泽东同志的著作和讲话,言简意赅,紧扣主题,深入浅出,不愧为开时代新文风的典范。 相似文献
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Sea cucumbers, Apostichopus japonicus Selenka, were fed diets containing non-immunostimulant (basal diet), 0.2% β-glucan and 0.02% glycyrrhizin in a recirculatory
water system for 45 days, and subsequently challenged with Vibrio splendidus by injection at 1.0×108 cfu / sea cucumber for 15 days. Phagocytic capacity (PC), intracellular superoxide anion production (ISAP), lysozyme (LSZ)
activity and superoxide dismutase (SOD) activity in the coelomic fluid were analyzed on the 0th, 5th, 10th and 15th days after injection. Results showed that after the 45-day feeding period, PC, ISAP, LSZ activity and SOD activity in sea
cucumbers fed with dietary β-glucan or glycyrrhizin were significantly higher than in those fed with the basal diet. On the
5th day after infection, all the immune parameters examined in the sea cucumbers injected with V. splendidus decreased in value significantly. On the 15th day, PC, ISAP and LSZ activity returned to levels similar to those on the 0th day. For the sea cucumbers injected with saline, there were no significant differences in all the immune parameters examined
and in the cumulative morbidity during the 15-day challenging trial. After injecting with V. splendidus, the cumulative morbidity of sea cucumbers fed with the basal diet was significantly higher than those fed with dietary β-glucan
or glycyrrhizin when challenged with V. splendidus challenged sea cucumber fed with the basal diet was significantly higher than those fed with dietary β-glucan or glycyrrhizin.
There was no significant difference in cumulative morbidity between the dietary β-glucan and glycyrrhizin treatments over
time. 相似文献
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《地球信息科学》编辑部 《地球信息科学学报》2008,10(4):446-446
为喜迎奥运,北京市城市规划与勘测研究院设计编印的“新北京.新奥运地图集”即将问世。这是一部创意新颖、印制精湛、图文并茂、中英对照、雅俗共赏、信息丰富、内容详实、科学性与艺术性都很高的成功新作。该图集已完成打样,2008年6月即将付印出版。图集的城区分幅图的总体设计非常成功。 相似文献
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“数字城市”与时俱进 总被引：2，自引：0，他引：2
陈述彭 《地球信息科学学报》2002,4(3):35-37
承继成、李琦、林珲教授和黄宝青、夏曙东博士合著的“数字城市--理论、方法和应用”的问世 ,对“数字城市”的发展趋势、概念和内涵 ,特别是对“数字城市”与各行业管理信息系统的密切关系 ,“数字鸿沟”、“数字分化”与“边缘化”的危机 ,从理论上进行了精辟的剖析 ,从案例中总结了实践的经验。全书高屋建瓴、统览宏观大局 ;纲举目张 ,细查关键技术。有幸先睹为快 ,谨记浅薄学习心得 ,欣然命笔 ,为青年学子导读 ,向从事“数字城市”建设的专家学者们郑重推荐。我国有 6 6 8个大中城市 ,大约有 3 0 0 0 0个小城镇。城市的数字化 ,只是迈向信息化和现代化的第一步 ,来日方长 ,任重道远。 相似文献
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“数字福建”及“数字闽东南”的构建与应用 总被引：2，自引：0，他引：2
余明 《地球信息科学学报》2003,5(2):32-35
本文介绍“数字福建”建设发展状况及实施目标和任务,结合闽东南地区数字化、网络化、可视化和智能化问题,提出闽东南可持续发展的几点建议。建设“数字闽东南”就是要实现闽东南区域网络平台集成、应用系统集成和信息资源集成的电子化、数字化和智能化。 相似文献
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“数字地球”科学工程 总被引：10，自引：0，他引：10
“数字地球”是集科学、技术和工程于一体的一项宏伟的科学体系。“数字地球”由基础研究、技术支撑和科学工程三部分组成,其中科学工程是“数字地球”的核心和目标。文章在我国“数字地球”科学工程现状分析的基础上,结合国情,对我国“数字地球”科学工程的发展提出了建议。 相似文献
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“数字地球”与地理信息科学 总被引：8，自引：0，他引：8
本文简要概括了数字地球的涵义及特征,分析了地理信息系统与地理信息科学的关系,概括了地理信息科学的主要内容,提出了建立地理信息科学的关键问题,指出发展地理信息科学首先要解决的是空间数据库和对地理现象的描述。 相似文献