共查询到20条相似文献，搜索用时 31 毫秒
1.
钙网蛋白（calreticulin,CRT）是参与多种细胞过程的高度保守的内质网伴侣蛋白。1974年,它首次被鉴定为钙离子结合蛋白,随后CRT与肿瘤之间信号通路相关关系被广泛的研究。另外,在人类多种肿瘤中,细胞表面的CRT被认为是1个"促吞噬"信号,由此CRT与癌细胞的巨噬细胞吞噬免疫系统的相关研究,有望为肿瘤综合治疗提供新的理论依据和策略。也有越来越多的证据表明CRT在不同肿瘤中的异常表达,将为CRT成为一种新的肿瘤标志物提供许多依据。以及CRT对各种肿瘤的发展具有很重要的影响且CRT对肿瘤形成和进展的影响取决于细胞类型和临床阶段。 相似文献
2.
Frost heave is an upward swelling of soil during cryogenic conditions in cold regions. It is caused by the accumulation of ice crystals in subgrade soil, which grow upwards when freezing temperatures penetrate into the subgrade. This study establishes the allowable soil subgrade frost heave based on the roughness standard of asphalt pavement in China, and aims to balance the pavement design and frost heave resistance of subgrades in cold regions. We formulated a mechanical model of pavement supported by the boundary conditions of differential frost heave, based on the elastic layered system theory. The differential soil subgrade frost heave was modeled as a sinusoidal function, and the allowable frost heave and the roughness index were modeled as the displacement boundaries for the top and bottom of the pavement structure. Then the allowable frost heave was back-calculated according to the roughness standard. Numerical results show that the allowable frost heave depends on the pavement structure, material properties, the highway grade, and other factors. In order to ensure that the actual soil subgrade frost heave is lower than the allowable frost heave, pavement structures and materials need to be selected and designed carefully. The numerical method proposed here can be applied to establish the frost heave resistance of subgrade when the pavement structure and materials are determined. 相似文献
3.
In seasonally frozen regions, the frost-heave properties of soil play a significant role in its upper-structure performance and durability. To investigate the frost-heave behaviors of saturated, compacted silty clay soil widely used as subgrade material, a series of one-side freezing tests was carried out; and the freezing depth and frozen front effected by the compactness, temperature, overburden pressure, and water-supply condition were analyzed and discussed. The results show that the moving speed of the frozen front and growth rate of the frozen depth are positively correlated. The frost heave is maximum in the frost-heave stability condition. The frost ratio of saturated soil is proportional to the water supply and cooling temperature under a one-side freezing condition. The frost ratio of saturated soil is inversely proportional to the initial compactness of the soil specimen and the overburden pressure. 相似文献
4.
This paper outlines development of the thickness design of cylindrical frozen walls in artificial ground freezing (AFG). A plain strain mechanical model coupled with infinite surrounding soil and rock ... 相似文献
5.
This paper aims to determine the optimal fines content of coarse-grained soil required to simultaneously achieve weaker frost susceptibility and better bearing capacity. We studied the frost susceptibility and strength properties of coarse-grained soil by means of frost heaving tests and static triaxial tests, and the results are as follows:(1) the freezing temperature of coarse-grained soil decreased gradually and then leveled off with incremental increases in the percent content of fines; (2) the fines content proved to be an important factor influencing the frost heave susceptibility and strength properties of coarse-grained soil. With incremental increases in the percent content of fines, the frost heave ratio increased gradually and the cohesion function of fines effectively enhanced the shear strength of coarse-grained soil before freeze-thaw, but the frost susceptibility of fines weakened the shear strength of coarse-grained soil after freeze-thaw; (3) with increasing numbers of freeze-thaw cycles,the shear strength of coarse-grained soil decreased and then stabilized after the ninth freeze-thaw cycle, and therefore the mechanical indexes of the ninth freeze-thaw cycle are recommended for the engineering design values; and (4) considering frost susceptibility and strength properties as a whole, the optimal fines content of 5% is recommended for railway subgrade coarse-grained soil fillings in frozen regions. 相似文献
6.
利用2015年9月采自青海北霍布逊湖区的原土样,自行配比进行了室内盐渍细砂土冻胀试验,研究了低干密度盐渍细砂土的低温特性变化规律,探讨了盐渍细砂土的冻胀机理,集中分析了土的冻缩特性。研究发现低干密度盐渍细砂土在不同含水率条件下土的冻胀规律差异很大。低含水率条件下会有冻缩现象,高含水率条件下只会有冻胀现象,临界含水率（含水率14%）条件下细砂土先出现冻缩,之后随着温度的降低又出现冻胀,且由于温度引起的体积变化均在-28℃～-30℃时达到稳定;土的冻缩随着含盐量增加先呈递增趋势,后又呈递减趋势,在中间含盐量10%达到最大;除临界含水率条件下,盐渍细砂土的冻胀、冻缩均与温度呈三次多项式关系,与含水率呈线性关系。研究结果能够为盐渍土地区的工程建设提供有价值的理论依据。 相似文献
7.
The uneven frost heave of frost-susceptible subgrade soil causes track irregularity, which highly enhances train vibration and affects the comfort and safety of railway transportation. This paper presents a coupled thermo-hydro-mechanical (THM) analysis for the freezing behavior of railway located above a box culvert. The vertical acceleration of the vehicle, an indicator of riding comfort, is predicted through a vehicle dynamic model. The results reveal that the existence of a box culvert changes the subgrade thermal pattern, leading to a deeper frost penetration depth. The frost heave amount above the box culvert is larger than the adjacent section, resulting in uneven track structure upheave and track irregularity. This frost-induced track irregularity highly affects train vibration. 相似文献
8.
The temperature distributions of different parts of a subgrade were analyzed based on the results of three years of monitoring data from the Harbin-Qiqihaer Passenger Dedicated Line, a high-speed railway, including the slope toes, shoulders, and natural ground. The temperature variation with time and the maximum frozen depths showed that an obvious sunny-shady effect exists in the railway subgrade, which spans a seasonal frozen region. Development of frost heave is affected by the asymmetric temperature distribution. The temperature field and the maximum frozen depths 50 years after the subgrade was built were simulated with a mathematical model of the unsteady phase transition of the geothermal field. 相似文献
9.
This paper set up a series of comprehensive targets based on the concept of 'anti-freeze filler', which include reasonable water retention rate, frost heave characteristics, and compaction characteristics of filling material. Then, a type of permeable graded gravel is proposed, suitable for high-speed railway subgrade. A series of in-door water retention, permeability, and frost heave tests were performed under different graded conditions. Water retention, permeability, and frost heave characteristic of different graded filling materials can be determined, in order to define the gradation range of permeable graded gravel. Relying on the frost-heave monitoring record of high speed railway in Northeast China, a series of experimental studies were performed, which included on-site filler production, compaction test, and the anti-frost effect test, in order to improve the production and compaction techniques of permeable graded gravel. From the research of this paper, the use of permeable graded gravel subgrade as the anti-frost structure for the high-speed railway subgrade in cold areas is feasible. 相似文献
10.
This paper presents methods for monitoring frost heave, device requirements, testing principals, and data analysis requirements, such as manual leveling observation, automatic monitoring (frost heave, frost depth, and moisture), track dynamic detection, and track status detection. We focused on the requirements of subgrade frost heave monitoring for high speed railways, and the relationship of different monitoring methods during different phases of the railway. The comprehensive monitoring system of high speed railway subgrade frost heave provided the technical support for dynamic design during construction and safe operation of the rail system. 相似文献
11.
DaiChao Sheng 《寒旱区科学》2021,13(2):87-94
Frost susceptibility is a concept widely used in cold region geotechnical design, to quantify the capacity of a soil in generating frost heave and frost damage. The laboratory test used to verify frost susceptibility of a soil is based on the measurement of frost heave generated in the soil under specific conditions. In reality this concept is, however, more related to the soil's potential to thaw weakening than to frost heave. Recent experimental studies show that frost non-susceptible soils like clean sand and clean gavel can also generate much ice segregation and frost heave if the conditions are favourable, hence challenging the usefulness and suitability of soil classification based on frost susceptibility. It is further shown that the concept is not suitable for design scenarios where frost heave itself is a serious hazard, such as in high-speed rail embankments. 相似文献
12.
Frost heave is one of the major complications in highway construction in cold regions. Laboratory experiments are im-portant in the study frost heave behavior of soils, and one-dimensional frost heave ... 相似文献
13.
Frozen ground is significantly stiffer than unfrozen ground. For bridges supported on deep foundations, bridge stiffness is also
measurably higher in winter months. Significant changes due to seasonal freezing in bridge pier boundary conditions require additional
detailing in order to ensure a ductile performance of the bridge during a design earthquake event. This paper reports the latest
results obtained from a project that systematically investigated the effects of seasonally frozen soil on the seismic behavior of
highway bridges in cold regions. A bridge was chosen and was monitored to study its seismic performance and assess the impact
of seasonally frozen soil on its dynamic properties. A Finite Element (FE) model was created for this bridge to analyze the impact
of seasonal frost. It was found that when frost depth reaches 1.2 m, the first transverse modal frequency increases about 200%
when compared with the no-frost case. The results show that seasonal frost has a significant impact on the overall dynamic behavior
of bridges supported by pile foundations in cold regions, and that these effects should be accounted for in seismic design. 相似文献
14.
Satoshi Akagawa 《寒旱区科学》2021,13(2):77-86
Since the 1970's, frozen ground has been developing near the Tokyo Bay area around liquefied natural gas(LNG) inground storage tanks. For disaster prevention purposes, the tanks are constructed below the ground surface. Since the temperature of the liquid stored in the tanks is -162℃ the soil surrounding the tanks freezes. Since this frozen ground has existed for almost half a century, we have permafrost near Tokyo. The development of artificial frozen ground may cause frost heaving, resulting in frost heave forces that may cause structural damage of adjacent LNG in-ground storage tanks.Therefore, the demand for frozen ground engineering increased and consequently we now have advanced technology in this area. Fortunately, we use this engineering technology and artificial ground freezing for civil engineering, especially in big and crowded cities like Tokyo. This paper provides a summary of the testing apparatus, test methods, and assessment methods for frost heaving. 相似文献
15.
Frost heave is one of the main freezing problems for construction in permafrost regions.The Konrad-Morgenstern segregation potential（SP） model is being used in practice for frost heave using numerical techniques.However,the heat release from in-situ and migrated water in the freezing zone could result in some numerical instability,so the simulation of frost fringe is not ideal.In this study,a semi-analytical solution is developed for frost heave prediction of clay soil.The prediction results to the two tests with different freezing mode with clay soil agree well with the tested behavior,which indicates the feasibility of the solution. 相似文献
16.
以1981—2018年内蒙古典型草原季节性冻土为研究对象,通过气候倾向率、Mann-Kendall法、多元线性回归等方法,分析最大冻土时空分布特征、年际、年代际变化,研究影响最大冻土深度变化的气象因子。结果表明：（1） 内蒙古典型草原季节性冻土冻结初日在9—11月,终日在4—6月,年内最大冻土深度出现在2—3月,深度在100~280 cm之间。（2） 最大冻土深度年际变化分为下开口抛物线型、上开口抛物线型、正弦曲线型,从最大冻土深度气候倾向率看呈现减小趋势的站点有68%。（3） 最大冻土深度年代际变化分为逐年代递减、减-增型和无明显变化规律,50%的站点在1989年以后最大冻土深度发生突变。（4） 多元线性回归表明气温冻结指数、年平均风速、年极端最低气温对最大冻土深度产生显著影响。该研究揭示了最大冻土深度存在退化的事实,为草原应对气候变化提供指导,为陆地土壤和大气碳循环交换的研究给出提示。 相似文献
17.
Construction of power transmission lines is becoming an important part of permafrost engineering in China.This paper reviews the construction status and problems of transmission lines in different countries,as well as corresponding solutions that would be of practical significance for sustainable engineering practices.Russia has the longest history of transmission line construction in permafrost areas,with transmission lines（mainly 220 kV and 500 kV） spanning approximately 100,000 km.However,all countries suffer from permafrost-related tower foundation stability problems caused by freezing-thawing hazards such as frost heave and thaw settlement,frost lifting,and harmful cryogenic phenomena.As point-line transmission line constructions,the lines,poles and towers should be reasonably selected and installed with a comprehensive consideration of frozen soil characteristics to effectively reduce the occurrence of freezing-thawing disasters.Reinforced concrete pile foundations are widely used in the permafrost regions,and construction in winter is also a universal practice.Moreover,facilitating engineering measures like thermosyphons are an effective way to reduce freezing-thawing hazards and to maintain the stability of tower foundations. 相似文献
18.
青藏高原西部区域多年冻土分布模拟及其下限估算 总被引：3，自引：0，他引：3
准确评估青藏高原西部多年冻土的空间分布及多年冻土下限深度情况对该区地下水资源利用、生态环境保护有重要意义.本文依托科技基础性工作专项“青藏高原多年冻土本底调查”在该区及周边取得的冻土调查资料,利用遥感数据和扩展地面冻结数模型模拟了该区多年冻土的空间分布,调查区的模拟验证表明该方法有较高的精度.在此基础上,根据有限的地温实测资料建立了地温与位置、高程、坡向和太阳辐射的关系,并根据地温-下限关系估算了该区多年冻土下限深度的分布情况.研究表明,该区有多年冻土约占36.9%,季节冻土占57.5%,多年冻土主要分布在34°N~36.5°N范围的喀喇昆仑、西昆仑一带,季节冻土主要分布在塔里木盆地和34°N以南地区.阿里高原及以南是岛状多年冻土分布区域,其多年冻土分布面积少于此前出版的冻土图所绘制的.青藏高原西部区域的多年冻土下限深度整体表现为由东南-西北逐渐加深. 相似文献
19.
A series of saline soil-related problems, including salt expansion and collapse, frost heave and thaw settlement, threaten the safety of the road traffic and the built infrastructure in cold regions. This article presents a comprehensive review of the physical and mechanical properties, salt migration mechanisms of saline soil in cold environment, and the countermeasures in practice. It is organized as follows:(1) The basic physical characteristics;(2) The strength criteria and constitutive models;(3) Water and salt migration characteristics and mechanisms; and(4) Countermeasures of frost heave and salt expansion. The review provides a holistic perspective for recent progress in the strength characteristics, mechanisms of frost heave and salt expansion, engineering countermeasures of saline soil in cold regions. Future research is proposed on issues such as the effects of salt erosion on concrete and salt corrosion of metal under the joint action of evaporation and freeze-thaw cycles. 相似文献
20.
Frost susceptibility should be considered in the design and construction of foundations and retaining-wall structures in regions with the seasonally freezing-soil ground condition. When planning construction that goes deep into this soil, one has to understand the impact of horizontal forces to an underground wall and realize the potential effect of frost heaving upon, deep foundations. This article presents a few soil tests for frost heaving and the results of those tests show dangerous data for retaining structures under the soil conditions in Kazakhstan. The main parameters of the soil include frost penetration and heaving rate and amount. So, in designing underground structures, one must understand and consider that frost heaving occurs in various directions; this factor is very important for predicting on the restriction of deformations of structures in the seasonally freezing-soil ground condition. 相似文献