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1.
Viroj Wiwanitkit Jamsai Suwansaksri Suphan Soogarun 《Stochastic Environmental Research and Risk Assessment (SERRA)》2008,22(2):281-283
Toluene is of particular concern because recent research indicating that toluene exposure can result in several toxicities.
Hence, toluene exposure is of particular concern because of ongoing exposure to thousands of workers in the industrial plants.
Determination of the urine hippuric acid level is accepted as a helpful for monitoring risk groups of workers. Apart from
the industrial workers, there are other occupations with high risk for toluene exposure. In this study, we study another at-risk
occupation, the police. In this study, 45 urine samples were obtained from 45 Thai police working close to traffic in an urban
area for determination for urine hippuric acid level. The average urine hippuric acid level was 0.70 ± 0.70 mg/gCr, respectively.
This average is significant higher than that of the control non-exposed Thais (P < 0.05). Working in the air pollution in the urban area can be health hazard for the police. Exposure to the toluene from
automobile exhaust can be an important occupational problem for these police. 相似文献
2.
J. P. Gaur 《洁净——土壤、空气、水》1988,16(6):617-620
The toxicity of some oil constituents, viz., benzene, toluene, xylene, naphthalene, methylnaphthalene, dimethylnaphthalenes, trimethylnaphthalene, phenol, cresol, aniline and toluidine towards S. capricornutum was investigated. All constituents exerted detrimental effects on algal growth and toxicity depended inter alia on the number of methyl groups in the test chemicals. Aniline, toluidine and alkylnaphthalenes were most toxic to test alga and if present at a high concentration in an oil, the toxic effects of that oil would be very severe. 相似文献
3.
Ling Gao Ying Wang Yang Xu Shi Lu Zhou Ting Ting Zhuang Zheng Ying Wu Jian Hua Zhu 《洁净——土壤、空气、水》2008,36(3):270-278
A new effort to control the pollution caused by smoking by use of zeolite sieving the N‐nitrosamines in smoke is depicted and assessed in this paper, which is a first preliminary approach to demonstrate the performance characteristics of zeolite for the reduction of the concentration of N‐nitrosamines in the cigarette smoke. Smoking causes global pollution and is difficult to control because smoke is a complex system containing thousands of components. A new strategy is presented here for the reduction of the harmful effects of smoking through dispersion of zeolite into the tobacco rod of cigarettes to eliminate the N‐nitrosamines once they form in the smoke, and both in vitro and in vivo tests were employed to check the efficiency of this strategy. The impact of zeolite on the combustion of tobacco and the total toxicity of smoke are evaluated for the first time. Lower mutagenic activity and higher CHO cell livability were found for the test cigarette containing zeolite in comparison with the control, and no significant damage was detected in 30‐day animal experiments when exposed to the cigarette smoke. This confirms the feasibility of the new strategy and promotes the potential application of zeolite for protecting public health. 相似文献
4.
Ling Gao Ying Wang Jia Hui Xu Yang Xu Yi Cao Zhi Yu Yun Chao Hong Jian Hua Zhu 《洁净——土壤、空气、水》2009,37(1):31-38
In order to protect the environment and public health, microwave irradiation was investigated as a means of reducing the nitrosamines level of tobacco smoke under mild conditions where the microwave energy was 1 kW and the irradiation time was shorter than 2 min. The microwave‐induced elimination of nitrosamines such as N‐nitrosopyrrolidine (NPYR) and N‐nitrosodiphenylamine (NDPA) was investigated and the impact of the presence of water and salt in the medium on the reduction was assessed in detail. The existence of water in the medium was crucial for the microwave‐induced reduction of NDPA, because the rapid movement of water molecules under the influence of microwaves strongly affects the adjacent nitrosamines leading to their decomposition. This was the first time that microwaves have been used to directly irradiate cigarettes sealed in their packaging, and the nitrosamines content of tobacco and smoke of these irradiated cigarettes were analyzed with care. Irradiation for 90 s with microwave energy of 1kW was seen to reduce 25 to 30% of the nitrosamines in tobacco and 50 to 60% of the levels present in the mainstream smoke of the cigarette. Moreover, lower mutagenic activity and higher CHO cell livability were found for the irradiated cigarettes in comparison with the control according to the results of in vitro tests. 相似文献
5.
目的：利用双源CT（DSCT）血管成像技术探讨吸烟与冠状动脉粥样硬化斑块之间的相关性。方法：收集本院2012年4月到2013年4月接受DSCT冠状动脉造影检查的患者病例,以调查问卷为分组依据,先分为吸烟组和非吸烟组,再以是否有家族遗传史或合并糖尿病、高血压、高血脂等高危因素为剔除标准。选择余下的单纯吸烟组200例和单纯不吸烟组200例为本实验的研究对象。观察并比较两组患者斑块的发生率、分布特点、狭窄程度与斑块类型。结果：病变累及血管支数及范围比较：吸烟组冠脉3支血管病变发生率为23.0%,非吸烟组为7.0%;吸烟组弥漫性病变发生率为46.0%,非吸烟组为14.5%,两组比较差异均有统计学意义（P〈0.05）。狭窄程度比较：吸烟组重度狭窄、完全闭塞的比例分别为27.5%、6.7%、非吸烟组分别为17.1%、3.7%,吸烟组较非吸烟组增高。斑块性质比较：吸烟组混合斑块的发生率为44.7%,非吸烟组为21.9%;而非钙化斑块的发生率,吸烟组为38.7%,非吸烟组为67.9%,两组比较差异均有统计学意义（P〈0.05）。经调整年龄、性别和体重指数的统计学处理后,证明吸烟是混合斑块的独立危险因素。而通过不同吸烟指数分组的两两比较,混合斑块的发生率随吸烟指数的递增而增加。结论：DSCT冠状动脉造影能够准确评价冠状动脉粥样硬化斑块在吸烟和非吸烟患者之间的差异,吸烟者混合斑块发生率更高,更处于易发心血管事件的高危状态。 相似文献
6.
Median times to narcotization (ET50) of Cirolana borealis Lilljeborg by various levels of toluene in seawater were determined. Narcotization quickly became irreversible, and the ET50 values can be regarded as estimates of median lethal times. Respiratory rate, ATP concentration, and energy charge (E.C.) were not significantly affected by sublethal toluene levels which caused behavioural disturbance. At 12.5 ppm of toluene (nominal concentration; ET50:69 h) ATP dropped gradually to less than 1% and E.C. to about 50% of the control values during 8 days, after which time all the individuals were dead. At 125 ppm neither ATP concentration nor E.C. changed significantly during 24 h although the animals were inactive after about 1 h and died within 100 h. Due to the high degree of stabilization of adenine nucleotide levels and E.C. during environmental changes, these parameters do not appear useful as general indices of stress in environmental pollution studies. 相似文献
7.
随着气候变化和人类活动的加剧,城市化地区水文过程受到较大影响,极端水文事件发生频率显著加大,探究城市化地区洪水演变和驱动机理对于防洪减灾具有重大意义。本文以长江下游快速城市化地区的秦淮河流域为例,分析了1987—2018年期间该流域年最大日径流的演变特征,构建多元线性回归模型和广义可加GAMLSS模型识别了关键驱动因子并量化其贡献作用。结果表明:(1)城市化背景下秦淮河流域年最大日径流呈现显著上升趋势,平均增长速率为14.77 m3/(s·a),并于2001年发生显著突变。(2)汛期降水量和不透水面率是年最大日径流变化的关键驱动因素,最优模型显示前者贡献率超过了70%,表明了降水改变的决定性作用,而不透水面率贡献率超过20%则表明了下垫面的改变对年最大日径流演变存在显著影响。(3)不透水面的增加对年最大日径流和汛期降水量响应关系的影响程度从突变前的6.7%增加到突变后的10.4%,快速城市化已显著改变了流域降水-径流响应过程。研究表明,随着城市发展秦淮河流域的年最大日径流受到人类活动显著影响,洪涝威胁日趋增大,研究结果可为城市化地区防洪减灾提供一定参考。 相似文献
8.
9.
Subramani Saravanan Govindan Nagarajan Radhakrishnan Ramanujam Santhanam Sampath 《洁净——土壤、空气、水》2011,39(6):515-521
The main objective of this work is to investigate the factors influencing the NOx control of a stationary diesel engine fuelled with crude rice bran oil blend with lesser effect on smoke density and brake thermal efficiency (BTE). Fuel injection timing, percentage of EGR, and fuel injection pressure are chosen as the factors for the objective and NOx emission, smoke density, and BTE are considered as the response variables. To critically analyze the effects of the chosen factors on the objective three levels were chosen in each factor and the experiments were designed by following the design of experiments method. Taguchi's L9 orthogonal array was used to conduct the tests with different combination of factor levels. Through analysis of variance (ANOVA) method, the most influencing factors and also the significance of each factor affecting each response variable were found out. Response graph was drawn for each response variable to determine the optimum combination of factor levels in achieving the objective and the obtained combination was confirmed experimentally. 相似文献
10.
Sundt RC Ruus A Jonsson H Skarphéðinsdóttir H Meier S Grung M Beyer J Pampanin DM 《Marine pollution bulletin》2012,64(1):144-152
Biological markers of produced water (PW) exposure were studied in Atlantic cod (Gadus morhua) in both laboratory and field experiments, using authentic PW from a North Sea oil field. In the laboratory study, the PW exposure yielded significantly elevated levels of metabolites of polycyclic aromatic hydrocarbons (PAHs) and alkylphenols (APs) in bile even at the lowest exposure dose (0.125% PW). Other biomarkers (hepatic CYP1A induction and DNA adduct formation) responded at 0.25% and 0.5% PW concentrations. In the field study, bile metabolite markers and hepatic CYP1A were clearly increased in fish caged close to the PW outfall. Induction of plasma vitellogenin was not found in laboratory or field exposures, suggesting that the levels of oestrogen agonists (such as APs) might not have been sufficient to elicit induction, under the present conditions. The applicability of the biomarkers for use in water column biomonitoring programs is discussed. 相似文献
11.
Experimentally, a feasibility study for adsorption and catalytic pyrolysis of spill oils on Cu/ZSM-5 for recycling of light oils has been conducted in the present work. The adsorption and pyrolysis of model compounds such as heptane, toluene, and diesel (to stimulate the spill oils) on Cu/ZSM-5 have been investigated on a continuous fixed-bed reactor. By component fitted X-ray absorption near edge structural (XANES) spectroscopy, catalytic active species such as metallic copper (Cu) (77-84%) and Cu(2)O (6-7%) are found in the channels of ZSM-5 during pyrolysis of heptane or toluene. Pyrolysis of diesel effected by Cu/ZSM-5 yields gas (C(1)-C(5)) (32%) and light oil (68%) that can be used as auxiliary fuels. 相似文献
12.
13.
《Marine pollution bulletin》2009,58(6-12):895-898
Experimentally, a feasibility study for adsorption and catalytic pyrolysis of spill oils on Cu/ZSM-5 for recycling of light oils has been conducted in the present work. The adsorption and pyrolysis of model compounds such as heptane, toluene, and diesel (to stimulate the spill oils) on Cu/ZSM-5 have been investigated on a continuous fixed-bed reactor. By component fitted X-ray absorption near edge structural (XANES) spectroscopy, catalytic active species such as metallic copper (Cu) (77–84%) and Cu2O (6–7%) are found in the channels of ZSM-5 during pyrolysis of heptane or toluene. Pyrolysis of diesel effected by Cu/ZSM-5 yields gas (C1–C5) (32%) and light oil (68%) that can be used as auxiliary fuels. 相似文献
14.
The detection of urinary polycyclic aromatic hydrocarbon (PAH) metabolites by fluorescence spectrophotometry is particularly effective as a practical means to assess PAH exposure in decapod crabs. However, the practical application of this technique has thus far only been tested for the European shore crab (Carcinus maenas) and only a few field studies have been conducted in heavily polluted areas. The present study evaluated the adaptability of this method as a rapid, cost-effective and non-destructive biomonitoring tool for the New Zealand crab species, Macrophthalmus hirtipes (stalk-eyed mud crab). A field gradient could be detected among the sites and different input sources of PAH contamination could be discerned through the differentiation of pyrogenic and petrogenic PAH signatures. The present study shows that the fluorescence screening method is sensitive to relatively low levels of PAH contamination and more broadly applicable to smaller crab species than C. maenas, for which the technique was developed. 相似文献
15.
Chu-Chih Chen Meng-Chiuan Shih Kuen-Yuh Wu 《Stochastic Environmental Research and Risk Assessment (SERRA)》2012,26(1):21-31
The use of a physiologically based toxicokinetic (PBTK) model to reconstruct chemical exposure using human biomonitoring data,
urinary metabolites in particular, has not been fully explored. In this paper, the trichloroethylene (TCE) exposure dataset
by Fisher et al. (Toxicol Appl Pharm 152:339–359, 1998) was reanalyzed to investigate this new approach. By treating exterior chemical exposure as an unknown model parameter, a
PBTK model was used to estimate exposure and model parameters by measuring the cumulative amount of trichloroethanol glucuronide
(TCOG), a metabolite of TCE, in voided urine and a single blood sample of the study subjects by Markov chain Monte Carlo (MCMC)
simulations. An estimated exterior exposure of 0.532 mg/l successfully reconstructed the true inhalation concentration of
0.538 mg/l with a 95% CI (0.441–0.645) mg/l. Based on the simulation results, a feasible urine sample collection period would
be 12–16 h after TCE exposure, with blood sampling at the end of the exposure period. Given the known metabolic pathway and
exposure duration, the proposed computational procedure provides a simple and reliable method for environmental (occupational)
exposure and PBTK model parameter estimation, which is more feasible than repeated blood sampling. 相似文献
16.
Robert Haining Jane Law Ravi Maheswaran Tim Pearson Paul Brindley 《Stochastic Environmental Research and Risk Assessment (SERRA)》2007,21(5):501-509
Bayesian modelling of health risks in relation to environmental exposures offers advantages over conventional (non-Bayesian)
modelling approaches. We report an example using research into whether, after controlling for different confounders, air pollution
(NOx) has a significant effect on coronary heart disease mortality, estimating the relative risk associated with different levels
of exposure. We use small area data from Sheffield, England and describe how the data were assembled. We compare the results
obtained using a generalized (Poisson) log-linear model with adjustment for overdispersion, with the results obtained using
a hierarchical (Poisson) log-linear model with spatial random effects. Both classes of models were fitted using a Bayesian
approach. Including spatial random effects models both overdispersion and spatial autocorrelation effects arising as a result
of analysing data from small contiguous areas. The first modelling framework has been widely used, while the second provides
a more rigorous model for hypothesis testing and risk estimation when data refer to small areas. When the models are fitted
controlling only for the age and sex of the populations, the generalized log-linear model shows NOx effects are significant at all levels, whereas the hierarchical log-linear model with spatial random effects shows significant
effects only at higher levels. We then adjust for deprivation and smoking prevalence. Uncertainty in the estimates of smoking
prevalence, arising because the data are based on samples, was accounted for through errors-in-variables modelling. NOx effects apparently are significant at the two highest levels according to both modelling frameworks.
相似文献
| Paul BrindleyEmail: |
17.
M.R Mortimer 《Marine pollution bulletin》2000,41(7-12):359-366
Trace metals, metalloids and pesticide content were quantified in intertidal burrowing crabs Australoplax tridentata and a portunid Scylla serrata sampled from estuaries on the east coast of Australia between Cairns and Brisbane. Residues of dieldrin occurred at all locations, heptachlor epoxide and DDT (principally metabolites DDD and DDE) at most, reflecting historical use. Chlordane, chlorpyrifos and endosulfan were only detected in crabs in the urban Brisbane area, and neither hexachlorobenzene (HCB) or polychlorinated biphenyls (PCBs) were quantifiable. Calculations of ambient exposures to organochlorines based on residues in crab tissues indicated that dieldrin exceeded national water quality guidelines for protection of aquatic ecosystems at all sampling locations, but exposure to DDT and its metabolites was below the threshold of concern. Concentrations of trace metals and metalloids generally reflected sediment data and likely sources. 相似文献
18.
R. Erben 《洁净——土壤、空气、水》1983,11(5):577-581
In an aerated batch experiment for one to six days the phenol accumulation is investigated in the surviving and killed larvae of Agrion puella at phenol concentrations of 50 to 200 mg/l in the medium. The rate of mortality increases with the initial concentration of phenol, although about 40% phenol is microbially digested during the test. The phenol accumulation in μg/g wet substance is always higher in the surviving individuals than in the killed ones, but it shows an identical time trend for both. On the first day, accumulation is high, and till the third day it decreases. On the fourth day, it reaches a maximum, and then it drops sharply to its minimum on the sixth day. The measured actual accumulation is the result of changing intake and elimination rates, especially the elimination rates decreasing with increasing duration of tests and test concentration due to metabolic disturbances. The absolute minimum on the sixth day is determined also by the reduced phenol concentration. The limit of accumulation for a chronic poisoning can be estimated at 70 μg/g phenol. 相似文献
19.
Associations between outdoor air quality and birth weight: a geostatistical sequential simulation approach in Coastal Alentejo,Portugal 总被引：3，自引：2，他引：1
Manuel Castro Ribeiro Pedro Pinho Esteve Llop Cristina Branquinho Amílcar Soares Maria João Pereira 《Stochastic Environmental Research and Risk Assessment (SERRA)》2014,28(3):527-540
Several environmental health studies suggest birth weight is associated with outdoor air pollution during gestation. In these studies, exposure assignments are usually based on measurements collected at air quality monitoring stations that do not coincide with health data locations. So, estimated exposures can be misleading if they do not take into account the uncertainty of exposure estimates. In this article we conducted a semi-ecological study to analyze associations between air quality during gestation and birth weight. Air quality during gestation was measured using a biomonitor, as an alternative to traditional air quality monitoring stations data, in order to increase spatial resolution of exposure measurements. To our knowledge this is the first time that the association between air quality and birth weight is studied using biomonitors. To address exposure uncertainty at health locations, we applied geostatistical simulation on biomonitoring data that provided multiple equally probable realizations of biomonitoring data, with reproduction of observed histogram and spatial covariance while matching for conditioning data. Each simulation represented a measure of exposure at each location. The set of simulations provided a measure of exposure uncertainty at each location. To incorporate uncertainty in our analysis we used generalized linear models, fitted simulation outputs and health data on birth weights and assessed statistical significance of exposure parameter using non-parametric bootstrap techniques. We found a positive association between air quality and birth weight. However, this association was not statistically significant. We also found a modest but significant association between air quality and birth weight among babies exposed to gestational tobacco smoke. 相似文献
20.
T. K. Hincks W. P. Aspinall P. J. Baxter A. Searl R. S. J. Sparks G. Woo 《Bulletin of Volcanology》2006,68(3):266-284
Frequent ash fallout from long-lived eruptions (with active phases greater than 5 years) may lead to local populations experiencing
unacceptably high cumulative exposures to respirable particulate matter. Ash from Montserrat has been shown to contain significant
levels of cristobalite and other reactive agents that are associated with an increased risk of developing pneumoconiosis (including
silicosis) and other long-term health problems. There are a number of difficulties associated with estimating risks in populations
due to uncertain and wide ranging individual exposures, change in behaviour with time and the natural variation in individual
response. Present estimates of risk in workers and other population groups are simplifications based on a limited number of
exposure measurements taken on Montserrat (1996–1999), and exposure−response curves from epidemiological studies of coal workers
exposed to siliceous dust. In this paper we present a method for calculating the long-term cumulative exposure to cristobalite
from volcanic ash by Monte Carlo simulation. Code has been written to generate synthetic time series for volcanic activity,
rainfall, ash deposition and erosion to give daily ash deposit values and cristobalite fraction at a range of locations. The
daily mean personal exposure for PM10 and cristobalite is obtained by sampling from a probability distribution, with distribution parameters dependent on occupation,
ground deposit depth and daily weather conditions. Output from multiple runs is processed to calculate the exceedance probability
for cumulative exposure over a range of occupation types, locations and exposure periods. Results are interpreted in terms
of current occupational standards, and epidemiological exposure−response functions for silicosis are applied to quantify the
long-term health risk. Assuming continuing volcanic activity, median risk of silicosis (profusion 1/0 or higher) for an average
adult after 20 years continuous exposure is estimated to be approximately 0.5% in northern Montserrat to 1.6% in Cork Hill.
The occupational group with the highest exposure to ash are gardeners, with a corresponding 2% to 4% risk of silicosis. In
situations where opportunities for in-depth exposure studies are limited, computer simulations provide a good indication of
risk based on current expert knowledge. By running the code for a range of input scenarios, the cost-benefit of mitigation
measures (such as a programme of active ash clearance) can be estimated. Results also may be used to identify situations where
full exposure studies or fieldwork would be beneficial.
Editorial responsibility: J Stix 相似文献