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Sulfate chitosan derivatives have good solubility and therapeutic effect on the cell model of NAFLD. The aim of this study was to examine the therapeutic effect of sulfate chitosan derivatives on NAFLD. The male Wistar rats were orally fed high fat emulsion and received sulfate chitosan derivatives for 5 weeks to determine the pre-treatment effect of sulfate chitosan derivatives on NAFLD. To evaluate the therapeutic effect of sulfate chitosan derivatives on NAFLD, the rats were orally fed with high concentration emulsion for 5 weeks, followed by sulfate chitosan derivatives for 3 weeks. Histological analysis and biomedical assays showed that sulfate chitosan derivatives can dramatically prevent the development of hepatic steatosis in hepatocyte cells. In animal studies, pre-treatment and treatment with sulfate chitosan derivatives significantly protected against hepatic steatohepatitis induced by high fat diet according to histological analysis. Furthermore, increased TC, ALT, MDA, and LEP in NAFLD were significantly ameliorated by pre-treatment and treatment with sulfate chitosan derivatives. Furthermore, increased TG, AST, and TNF-α in NAFLD were significantly ameliorated by treatment with sulfate chitosan derivatives. Sulfate chitosan derivatives have good pre-treatment and therapeutic effect on NAFLD. 相似文献
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总结国医大师刘祖贻教授基于“杂病调脾、和调五脏”理论辨治肝癌的经验。首先全面探讨杂病治脾调中的中医学术思想,深刻剖析肝病传脾、先实脾土的传变防治理论渊源。其次阐明了肝癌本虚标实的病机特点及肝病传脾由实转虚、虚实夹杂的证候演变规律。最后详细分析总结了刘老治脾调中治肝癌的辨治特色,临证常分早、中、晚三期论治,早期当疏肝行气、健脾扶正;中期当健脾解毒,佐以活血化瘀、清热利湿;晚期则当扶正安邪,重在顾护脾胃。三期虽攻补偏重不同,但活血化瘀应贯穿其整个治疗过程。 相似文献
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