月华丸（胶囊）对耐多药结核分枝杆菌感染后细胞自噬的影响          下载免费PDF全文

宁尚圣  伍参荣  欧阳建军 《应用海洋学学报》2019,35(2):130-132

目的：研究月华胶囊对耐多药结核分枝杆菌感染后细胞自噬的影响,以探寻其可能的抗耐多药结核分枝杆菌作用机制。方法：以月华胶囊含药血清作用于耐多药结核分枝杆菌感染的小鼠单核巨噬细胞（RAW264.7）,观察其对感染后细胞自噬的影响。实验分组：①阴性对照组（耐多药结核分枝杆菌+小鼠单核巨噬细胞）;②月华胶囊含药血清组;③月华胶囊含药血清+自噬抑制剂3-甲基腺嘌呤（3-MA）组;④阳性对照雷帕霉素组;⑤正常空白组。指标检测：在透视电镜下观察月华胶囊含药血清对耐多药结核分枝杆菌感染的小鼠单核巨噬细胞（RAW264.7）自噬体出现和形成的影响。结果：透射电镜显示,阴性对照组、空白对照组和自噬抑制剂3-甲基腺嘌呤组中均未见自噬小体;10%月华胶囊含药血清组及阳性对照雷帕霉素组可见自噬小体的出现和形成。结论：月华胶囊含药血清对耐多药结核分枝杆菌感染小鼠单核巨噬细胞（RAW264.7）自噬有促进作用,通过诱导巨噬细胞自噬杀灭结核分枝杆菌可能是月华胶囊抗结核、抗耐多药结核的机制之一。  相似文献   

基于图像相减和随机森林的AST3巡天暂现源及变源搜寻方法          下载免费PDF全文

黄天君  孙天瑞  胡镭  宁宗军  吴雪峰  王力帆  王晓峰  朱镇熹  UDDIN Ashraf Sye  ASHLEY Charles Brewster Michael 《天文学报》2019,60(5):98-114

AST3-2 (Antarctic Survey Telescopes)光学巡天望远镜位于南极大陆最高点冰穹A,其产生的大量观测数据对数据处理的效率提出了较高要求.同时南极通信不便,数据回传有诸多困难,有必要在南极本地实现自动处理AST3-2观测数据,进行变源和暂现源观测的数据处理,但是受到低功耗计算机的限制,数据的快速自动处理的实现存在诸多困难.将已有的图像相减方案同机器学习算法相结合,并利用AST3-2 2016年观测数据作为测试样本,发展一套的暂现源及变源的筛选方法成为可行的选择.该筛选方法使用图像相减法初步筛选出可能的变源,再用主成分分析法抽取候选源的特征,并选择随机森林作为机器学习分类器,在测试中对正样本的召回率达到了97%,验证了这种方法的可行性,并最终在2016年观测数据中探测出一批变星候选体.  相似文献   

Community structure of picoplankton abundance and biomass in the southern Huanghai Sea during the spring and autumn of 2006   总被引：2，自引：0，他引：2  

LE Fengfeng  NING Xiuren  LIU Chenggang  HAO Qiang  SHI Junxian 《海洋学报(英文版)》2010,29(1):58-68

During spring and autumn of 2006,the investigations on abundance,carbon biomass and distribution of picoplankton were carried out in the southern Huanghai Sea(Yellow Sea,sHS) . Three groups of picoplankton-Synechococcus(Syn) ,Picoeukaryotes(PEuk) and heterotrophic bacteria(BAC) were identified,but Prochlorococcus(Pro) was undetected. The average abundance of Syn and PEuk was lower in spring(5.0 and 1.3 × 10 3 cells/cm 3,respectively) than in autumn(92.4 and 2.7 × 10 3 cells/cm 3,respectively) ,but it was opposite for BAC(1.3 and 0.7 × 10 6 cells/cm 3 in spring and autumn,respectively) . And the total carbon biomass of picoplankton was higher in spring(37.23 ± 11.67) mg/m 3 than in autumn(21.29 ± 13.75) mg/m 3 . The ratios of the three cell abundance were 5:1:1 341 and 30:1:124 in spring and autumn,respectively. And the ratios of carbon biomass of them were 5:7:362 and 9:4:4 in spring and autumn,respectively. Seasonal distribution characteristics of Syn,PEuk,BAC were quite different from each other. In spring,Syn abundance decreased in turn in the central waters(where phytoplankton bloom in spring occurred) ,the southern waters and inshore waters of the Shandong Peninsula(where even Syn was undetected) ;the high values of PEuk abundance appeared in the central and southern waters and the inshore of the Shandong Peninsula;the abundance of BAC was nearly three order of magnitude higher than that of photosynthetic picoplankton,and high values appeared in the central waters. In autumn,Syn abundance in central waters was higher than that in surrounding waters,while for PEuk abundance,it decreased in turn in the inshore waters of the Shandong Peninsula,the southern waters and the central waters;BAC presented a complicated blocky type distribution. Sub-surface maximum of each group of picopalnkton appeared in both spring and autumn. Compared with the available literatures concerning the studied area,the range of Syn abundance was larger,and the abundance of BAC was higher. In addition,the conversion factors for calculating picoplanktonic carbon biomass were discussed,with the conversion factors which are different from previous studies in the same surveyed waters. The result of regression analysis showed that there was distinct positive correlation between BAC and photosynthetic picoplankton in spring(r=0.61,P 0.001) ,but no correlation was found in autumn.  相似文献   

湛江市金融业对经济增长作用的实证分析与对策研究     

宁凌 《广东海洋大学学报》2009,29(2)

以湛江金融业发展的实际数据为基础,选取经济货币化程度、经济金融化程度以及保险市场发育程度三个指标来衡量湛江市金融市场的状况,选择国内生产总值(GDP)和人均GDP作为经济增长的衡量指标;运用计量分析方法,对湛江市经济增长与金融发展之间的关系进行了实证分析;并依据计量分析的结果,对如何促进湛江市金融业的健康发展,提出了对策与建议。  相似文献   

珠江口冬季小型原生动物的分布及其影响因素的初步研究     

蓝文陆  黄邦钦  黄凌风  宁修仁  袁梁英 《海洋科学》2009,33(5):11-16

分析了2004年2月珠江口小型原生动物(包括鞭毛虫、纤毛虫和异养甲藻)的分布特征,探讨了环境因子对其分布的影响.结果表明,鞭毛虫在珠江口的丰度为3.4×103～25.6×103个/mL,异养甲藻的丰度为11～312个/mL,纤毛虫的丰度为7～172个/mL.高丰度的原生动物主要集中在广州附近盐度为2～5的河口上段,而低丰度在外海盐度超过30的下段区域,原生动物的3个类群的丰度均从上段往下段呈递减的趋势.原生动物的分布特征与浮游植物叶绿素a的分布特征相似,原生动物也与细菌呈显著的正相关,表明细菌和浮游植物影响着原生动物在珠江口内的分布.冬季温度对原生动物的分布不具有直接的影响作用,而营养盐可能是通过影响浮游植物及细菌的分布而间接对原生动物的分布产生影响.原生动物的丰度表明珠江口部分水域已处于富营养化和超营养化状态.  相似文献   

中、日、韩三国测绘法对测绘成果管理的规定     

宁镇亚 《测绘与空间地理信息》2009,32(5):213-214,218

测绘成果管理是一个国家测绘管理活动的重要组成部分。本文采用文献资料法、对比分析法,以中、日、韩三国的测绘法中关于测绘成果管理的规定为例,从测绘分类、测绘成果汇交、查阅和提供等方面探讨其共性和差异性,取长补短,以促进我国测绘成果管理机制建设。  相似文献   

基于Clementine和ULCN2005的月球测图研究     

宁晓刚  Bruce King  张继贤 《测绘学报》2009,38(4)

为使用嫦娥一号三线阵光学影像进行月球测图,本文研究月球测图的特殊性问题及其解决方案,提出基于Cle-mentine卫星影像数据和ULCN 2005月球控制网进行月球测图的方法,应用商业数字摄影测量软件和自主研发的辅助软件系统进行了月球测图实验.该实验选择了月球近南极的一块区域(W109.7°～W163.4°,S69.3°～S84.2°,面积约1.5×105km2),采用10个轨道的60景Clementine的UVVIS影像、408个ULCN 2005控制点(其中56个作为检查点)和1 337个连接点,建立该区的DTM和地形图,水平中误差和垂直中误差分别为98.639 m(0.19pixel)和1 003.751 m(1.93pixel).论证基于嫦娥数据生成月球DTM和地形图的可行性.  相似文献   

基于测井曲线分形维的碳酸盐岩孔隙结构分类方法     

王敏  胡松  宁从前  田飞 《地球物理学进展》2021,36(2):668-674

非均质储层的孔隙结构与物性、渗流、电性等特征密切相关,是影响储层品质及流体性质的重要因素.利用常规测井曲线实现全井段孔隙结构定量评价对于储层非均质性评价具有重要意义.首先根据岩心压汞资料对孔隙结构进行分类,依据分形理论求取不同测井曲线的分形维数,通过对比选取反应孔隙大小的孔隙度测井曲线盒维数和反应孔隙连通程度的电阻率曲...  相似文献   

Analysis of groundwater recoverable resource by numerical method in Linfen Basin of Shanxi, North China     

Liping BAI    Yeyao WANG  Jinsheng WANG . Chinese Research Academy of Environmental Sciences  Beijing  China. College of Water Sciences  Beijing Normal University  Beijing  China 《东北亚地学研究》2008,11(3):168-173

Calculation of the groundwater recoverable resource is the main part of groundwater resource evaluation. The three-dimensional groundwater flow model in Linfen Basin was established by GMS software. Then the numerical model was calibrated by observed groundwater level from February to December in 2 000. Based on the calibrated model, the groundwater recoverable resource is calculated. The simulation result shows that under the given value of the groundwater recoverable resource, the groundwater level would decrease significantly in the first 1 000 days, while the water level would drop slowly in 1 000 to 2 000 days, and the water level change tend to be stable after 2000 days.  相似文献   

西天山北部大地构造背景与成矿关系及找矿预测     

隗合明  王全庆  宁晰春 《地球科学与环境学报》1999,21(4):14-18

西天山金属矿产十分丰富,是我国重要的Ｃｕ、Ａｕ 等多金属成矿带。金属矿床的形成及其成矿特点与大地构造背景密切相关。在拉张大地构造背景下主要形成与中基性和中酸性火山岩有关的Ｃｕ、Ｆｅ、Ａｕ 等矿床,次为与中酸性侵入岩有关的Ｃｕ、Ｍｏ、Ｗ、ＰｂＺｎ 等矿床及与基性、超基性侵入岩有关的ＣｕＮｉ 矿床。在挤压大地构造背景下,主要形成与重熔型花岗岩有关的斑岩型、矽卡岩型和热液型Ｃｕ矿、Ａｕ 矿等,次为沉积改造型ＰｂＺｎ 矿和Ｃｕ 矿床。文中还讨论了大地构造演化的不同时期金属矿床形成的主要特点,并据大地构造背景等成矿条件对西天山北部进行了找矿预测。  相似文献