Tensile strength of large-scale incipient rock joints: a laboratory investigation     

J. Shang  L. J. West  S. R. Hencher  Z. Zhao 《Acta Geotechnica》2018,13(4):869-886

In this paper, a testing methodology was developed in the laboratory to measure the tensile strength of large-scale incipient rock joints. In the test, an expansive grout was used to develop the tensile force. Each test comprises two phases: Phase i test and Phase ii test. The Phase i test identified sample failure time, while the Phase ii test measured the corresponding tensile force arising from the expansive grout. Ostensibly homogeneous rock samples without incipient joints were firstly tested to establish the methodology. Tensile strength of block samples containing incipient rock joints was then measured using the established testing scheme. The test results have been compared with those obtained from conventional Brazilian and uniaxial tension tests as suggested by ISRM. The proposed approach is capable of giving a measure of tensile strength of large-scale incipient rock joints, although somewhat smaller strength than that from the standard approaches was occasionally measured in the preliminary tests on ostensibly homogeneous samples. Effects of stress concentration, sample scale, loading rate and expansive tensile force on the testing results were discussed. Furthermore, this simple and practical testing scheme is proposed for the measurement of the in situ tensile strength of rock and incipient discontinuities in the field, which if successful will provide a more scientific guidance on the rock mass classification and engineering design.  相似文献   

基于网络药理学与体外细胞实验探讨复方清痹片治疗类风湿性关节炎的作用机制          下载免费PDF全文

黄上  朱克俭  李仲普 《应用海洋学学报》2022,38(10):175

目的：基于网络药理学与体外细胞实验探讨复方清痹片治疗类风湿性关节炎(RA)的作用机制。方法：基于TCMID、TCMSP和DrugBank数据库筛选复方清痹片的活性成分并预测潜在活性成分靶点;基于GeneCard、OMIM等数据库筛选RA疾病靶点;明确复方清痹片活性成分与RA的共同潜在靶标;利用STRING数据库和Cytoscape软件构建蛋白质-蛋白质相互作用（PPI）网络,并通过DAVID数据库进行基因本体（GO）功能及京都基因与基因组百科全书（KEGG）通路富集分析,RT-PCR检测复方清痹片对肿瘤坏死因子（TNF-α）诱导的人类风湿性关节炎成纤维样滑膜细胞（HFLS-RA）模型白介素6（IL-6）、TNF-α、丝氨酸/苏氨酸蛋白激酶1（AKT1）和血管内皮生长因子A（VEGFA）mRNA表达的影响。结果：筛选出217种潜在活性成分以及158个潜在靶点;IL-6、TNF、AKT1、白蛋白（ALB）、VEGFA等是复方清痹片治疗RA的关键靶点;复方清痹片主要通过炎性因子、趋化因子、免疫调控等信号通路来发挥治疗RA的作用。复方清痹片能够抑制HFLS-RA增殖,下调IL-6、TNF、AKT1和VEGFA mRNA的表达,这与网络药理学预测的结果相一致。结论：本研究揭示了复方清痹片治疗RA“活性成分-靶点-通路”的复杂关系,为后续该药的临床应用提供了研究基础。  相似文献   

大城市医疗健康资源空间交互及其网络演化——以郑州中心城区为例     

冉钊  高尚  杨捷  高建华  张佰发 《地理研究》2022,41(2):494-508

认知资源要素在地表人文活动中的空间交互性对地理学研究具有重要意义。本文基于人文-经济地理学相关理论,从“单资源-复合资源-资源网络”多尺度视角出发,初步构建了医疗健康资源空间交互研究的基本理论框架,利用2012年和2020年百度地图POI数据,综合运用Ripley's K函数、格网熵指数、协同区位商以及社会网络分析等定量方法,从集聚交互、功能交互和网络交互3个方面研究郑州市医疗健康资源空间交互及其网络演化特征。结果表明：① 从集聚交互上看,各类医疗健康资源在数量和增速上扩张明显,同时呈现出显著集聚特征且集聚程度逐步增强,相对而言,更具综合性的医院健康资源的集聚程度最高;多距离下各类医疗健康资源集聚规模差异在不断缩小,集聚交互向良性方向发展。② 从功能交互上看,医疗健康资源的功能主导类型逐渐复杂,交互复合性逐步增强。医疗健康资源功能交互空间格局经历了主导类型由“单功能为主、多功能兼容”向“多功能为主、单功能为辅”转变,由点状格局到连片发展的蔓延模式与空间跳跃的飞地模式并存的转变特征。③ 从网络交互上看,医疗健康资源网络密度基本保持稳定,网络联系性质演化特征明显。诊疗与医药健康资源始终处于强联系的地位,存在集聚促进机制;理疗健康资源在关联网络中联系强度逐步提高,网络地位有所上升;而医院健康资源以其独有的规模大、高品质和综合性等特征在网络体系中具有较强独立性。  相似文献   

Extraction of Gravity–Magnetic Anomalies Associated with Pb–Zn–Fe Polymetallic Mineralization in Luziyuan Ore Field,Yunnan Province,Southwestern China     

Shang  Zhi  Chen  Yongqing  Xu  Xiaoting  Zhao  Binbin 《Natural Resources Research》2022,31(4):1963-1979

The method of bi-dimensional empirical mode decomposition (BEMD) and the combined methods of entropy weight–Technique for Order of Preference by Similarity to an Ideal Solution (TOPSIS) were used to decompose gravity–magnetic data and evaluate targets in the Luziyuan Pb–Zn–Fe polymetallic ore field and surrounding areas. Three meaningful bi-dimensional intrinsic mode function (BIMF) images were obtained by BEMD at different wavelengths, depicting different layers of geological architectures in the study area. The results are as follows. (1) The BIMF2 images depict the shallow local geological architecture and show positive gravity–magnetic anomalies of the skarn alteration and Pb–Zn–Fe mineralization distributed around concealed granites. (2) The BIMF3 images depict the medium-depth geological architecture, indicating that concealed granitic stocks, which are shallow extensions of a deeply concealed pluton, intruded along the NE-trending fault. (3) The BIMF4 images depict gravity–magnetic anomalies at greater depth, which likely reflect regional geological architectures, indicating the potential presence of a large, concealed intermediate-acid pluton in the negative anomaly zone. Three potential targets (A, B, and C) were delineated based on BEMD results of the original gravity–magnetic data. The entropy weight–TOPSIS evaluation results show that the ranking of the metallogenic potential of the delineated targets in the study area is B, A, and C, with relative proximity values of 0.4576, 0.3925, and 0.1499, respectively. The results of this study can be used to guide future exploration.

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基于快速鲁棒性主成分分析的日冕喷流自动检测方法     

耿成杰  李润鑫  刘辉  尚振宏 《天文研究与技术》2022,(1)

使用快速鲁棒性主成分分析(Fast Robust Principal Component Analysis,Fast RPCA)方法对日冕序列图像中的日冕喷流活动进行检测。检测的基本思路是利用快速鲁棒性主成分分析方法中低秩和稀疏分解的思想与日冕序列图像中有着变化尺度稍小且占比较大的随机变化背景成分、变化尺度较大且占比较小的日冕喷流的特点相结合,实现随机复杂多变的动态背景和稀疏运动目标之间的分离,从而检出作为前景变化的日冕喷流。采用太阳动力学天文台(Solar Dynamics Observatory,SDO)卫星的大气成像仪(Atmospheric Imaging Assembly,AIA)两组不同时间段、不同波段、不同观测位置的日冕序列图像作为研究对象。研究内容主要包括日冕序列图像的预处理、日冕喷流检测、快速鲁棒性主成分分析方法与帧间差分法的检测结果对比分析。实验结果表明,与帧间差分法相比,快速鲁棒性主成分分析方法能够检出强度较弱的日冕喷流,且提高了日冕喷流检测的准确度。  相似文献   

塔里木地块西北缘阿克苏地区新元古代冰碛岩年代与冰期事件     

李王鹏  王毅  李慧莉  张仲培  刘少峰  杨伟利  蔡习尧  聂海宽  钱涛  李晓剑 《现代地质》2022,36(1):27-47

塔里木地块新元古代冰期事件等时性对比存在争议,获得可靠的新元古代冰碛岩沉积时代意义重大.塔里木地块西北缘阿克苏地区出露2套新元古代冰碛岩沉积,通过对其进行岩石学、同位素年代学、岩石地球化学等分析,明确其沉积物岩石组合特征、限定其沉积时代、讨论其古气候风化条件等.化学蚀变指数(CIA)指示研究区的2套新元古代冰碛岩代表了...  相似文献   

北京及周边地区2013年1—3月PM_2.5变化特征          下载免费PDF全文

靳军莉  颜鹏  马志强  林伟立  刘宁薇  马建中  张晓春  贾小芳 《应用气象学报》2014,25(6):690-700

2013年1—3月北京及周边地区雾、霾高发,气候特征异于常年。利用2013年1—3月北京及周边地区6个地面观测站观测资料,研究PM_2.5和黑碳 (BC) 的质量浓度、区域分布特征及气象要素的影响情况。结果表明:北京及周边地区PM_2.5污染呈区域性高值、污染局地积累以及由南向北输送的特征。北京上甸子站在雾、霾与清洁期间BC与PM_2.5质量浓度的比值分别为7.1%和10.3%,雾、霾期间低于清洁期间;而河北固城站在雾、霾与清洁期间BC与PM_2.5质量浓度的比值分别为17.5%和11.9%,雾、霾期间明显高于清洁期间。二者相反的比值特征反映在清洁的下游地区雾、霾过程中二次生成的气溶胶所占比例较污染的上游地区偏高。  相似文献   

Examination and parameterization of the root water uptake model from stem water potential and sap flow measurements   总被引：2，自引：0，他引：2  

Yuting Yang  Huade Guan  John L. Hutson  Hailong Wang  Caecilia Ewenz  Songhao Shang  Craig T. Simmons 《水文研究》2013,27(20):2857-2863

A simple field‐based method for directly parameterizing root water uptake models is proposed. Stem psychrometers and sap flow meters are used to measure stem water potential and plant transpiration rate continuously and simultaneously. Predawn stem water potential is selected as a surrogate for root zone soil water potential to examine and parameterize the root water uptake–water stress response functions. The method is applied to two drooping sheoak (Allocasuarina verticillata) trees for a period of 80 days, covering both a dry season and a wet season. The results indicate that the S‐shape function is more appropriate than the Feddes piecewise linear function for drooping sheoak to represent the effect of soil moisture stress on its root water uptake performance. Besides, the water stress function is found to be not only a function of soil moisture but also dependent of the atmospheric demand. As a result, the water stress function is corrected for the effect of atmospheric conditions. Copyright © 2012 John Wiley & Sons, Ltd.  相似文献   

Deep-Seated Slope Failures Induced by Inappropriate Cutting in China     

Hong-Yue Sun  Yu Zhao  Yue-Quan Shang  Yang Yu  Quan-Li Zhao 《Rock Mechanics and Rock Engineering》2012,45(6):1103-1111

Given insufficient geological investigation and inadequate interpretation of geological settings, remedial works for localized cut slope collapses may induce large-scale failures and cause remarkable damage, as well as economical loss. A number of recent reports have addressed individual large-scale failures due to inappropriate cutting, but the systematic classification of failure patterns has received less attention. In this study, a re-profiling triggered landslide is described in detail. The deep slip surface is located by field measurements; then, the stability of the slope before and after cutting is assessed with the limit equilibrium method. Three types of slopes prone to deep-seated failures are introduced: the loose deposits type, the ancient landslide type, and the deep adverse discontinuities type. The mechanism of each failure pattern is illustrated with a case study. The stability analyses indicate that inappropriate slope profiling may greatly reduce the factor of safety (FS) of a slope. Recommendations are given for mitigating the deep-seated landslide induced by inappropriate cutting, and a case history of successful measures is presented.  相似文献   

Experimental studies of groundwater pipe flow network characteristics in gravelly soil slopes     

Hong-yue Sun  Louis Ngai Yuen Wong  Yue-quan Shang  Bo-ting Yu  Zhi-lei Wang 《Landslides》2012,9(4):475-483

Piping flow networks have often been identified in hydrogeological field studies of gravelly soil slopes in the southern part of China. The present experimental studies have shown that under long-term groundwater seepage, piping flow networks gradually develop in the slope. Factors affecting the development of flow pipe seepage network included the grain size distribution, the degree of soil compaction, and soil depth. Piping seepage networks favorably form if the content of the gravel was high, the soil cohesion was low, the degree of the soil compaction was low, or the soil depth was shallow. Due to the enhanced permeability associated with the presence of flow pipe seepage network in gravelly soil slopes, groundwater can be effectively drained away. This can beneficially prevent the rise of groundwater level in the slope during raining seasons, hence reducing pore water pressure along the potential failure surface and increasing slope stability. Once the flow pipe seepage network was disturbed or damaged, the water level in the upper portion of the slope experienced a great rise, hence reducing the slope stability. Therefore, slope toe excavation and excessive loading at the slope crest should be avoided for slopes with well-developed flow pipe seepage network in order to preserve it.  相似文献