基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制          下载免费PDF全文

王家辉  王军文  彭湘宁 《应用海洋学学报》2024,40(2):189

目的：基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制。方法：应用TCMSP和UniProt数据库平台查询青蛇方组方的有效活性成分及靶基因,与疾病靶基因取交集后构建蛋白质-蛋白质相互作用(PPI)网络;应用DAVID数据库,对潜在核心作用靶点基因进行基因本体（GO）功能、京都基因与基因组百科全书（KEGG）通路富集分析。利用分子对接原理论证青蛇方生物活性成分与核心靶点的分子结合能力。结果：筛选出青蛇方有效成分63种,作用靶点99个;主要有β-谷甾醇、2,4,7-三羟基-9,10-二氢菲、靛蓝素、豆甾醇、色氨酸等关键成分;转录因子AP-1（JUN）、肿瘤坏死因子（TNF）、原癌基因（RELA）、干扰素γ（IFNG）、转化生长因子-β1（TGF-β1）等核心基因。关键信号通路有癌症信号通路、恰加斯病通路、弓形体病通路、脂质和动脉粥样硬化通路等,分子对接结果显示活性成分与核心靶点基因结合能力较强。结论：青蛇方外用可以通过多种活性成分、多种通路有效抑制免疫炎症反应,促进免疫系统正常运行,从而达到治疗湿疹的目的。  相似文献   

利用主成分分析改善土地利用变化的遥感监测精度——以珠江三角洲城市用地扩张为例   总被引：41，自引：7，他引：34  

黎夏  叶嘉安 《遥感学报》1997,1(4):282-289

近年来,珠江三角洲由于经济的快速发展,城市用地急剧增加,利用多时相的遥感图,可以定量地监测这种城市化的现象。但理,由一般的遥感动态监测方法所得的结果往往夸大变化的程度,以及获得一些不合理的结论．该文提出主成分分析的方法来改善遥感动态监测的精度。将该方法应用应用于珠江三角洲发展最快的东莞市,获得了较满意的结果。  相似文献   

北京云蒙山地区花岗岩穹隆及伸展构造的探讨   总被引：9，自引：0，他引：9  

张建新  曾令森 《地质论评》1997,43(3):232-240

北京云蒙山花岗岩为一中生代侵入的花岗岩穹隆,花岗岩穹隆的叶理普遍发育,叶理轨迹基本平行于穹隆的外部边界,并显示出从核部到边部逐渐增强,东南侧明显强于西北侧的特点。变形构造研究显示,花岗岩穹隆的边部及围岩中普遍存在不同层次及不同运动方向的伸展构造。东南侧以具河防口－水峪伸展型韧性剪切带为特征,剪切运动标志显示为从ＮＷ－ＳＥ的正剪切运动,有限应变分析估算其剪切位移量在１０ｋｍ以上,剪切带上部被河防口正  相似文献   

豫西后造山阶段存在变质核杂岩吗？   总被引：2，自引：1，他引：1  

曹高社  赵太平 《地质论评》1997,43(4):365-372

不少学者用变质核杂岩模式解释豫西造山阶段基底隆起和与之相伴的盆岭构造的构造格局。介一本区基底隆起的形态、机制、时限和地壳剥露层次均没有变质核杂岩特征与基底隆起相伴的断陷人舅地也不同于变质核杂岩模式中的半地堑。  相似文献   

Research on temporal and spatial distribution, evolutionary character and mechanism of crustal deformation field before and after the Tangshan earthquake   总被引：2，自引：0，他引：2  

周硕愚  施顺英  帅平 《地震学报(英文版)》1997,10(6):693-701

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Efficient generation of conditional simulations by chebyshev matrix polynomial approximations to the symmetric square root of the covariance matrix     

C. R. Dietrich  G. N. Newsam 《Mathematical Geology》1995,27(2):207-228

Consider the problem of generating a realization y₁ of a Gaussian random field on a dense grid of points ₁ conditioned on field observations y₂ collected on a sparse grid of points ₂. An approach to this is to generate first an unconditional realization y over the grid =_{1 2}, and then to produce y₁ by conditioning y on the data y₂. As standard methods for generating y, such as the turning bands, spectral or Cholesky approaches can have various limitations, it has been proposed by M. W. Davis to generate realizations from a matrix polynomial approximations to the square root of the covariance matrix. In this paper we describe how to generate a direct approximation to the conditional realization y₁, on ₁ using a variant of Davis' approach based on approximation by Chebyshev polynomials. The resulting algorithm is simple to implement, numerically stable, and bounds on the approximation error are readily available. Furthermore we show that the conditional realization y₁ can be generated directly with a lower order polynomial than the unconditional realization y, and that further reductions can be achieved by exploiting a nugget effect if one is present. A pseudocode version of the algorithm is provided that can be implemented using the fast Fourier transform if the field is stationary and the grid ₁ is rectangular. Finally, numerical illustrations are given of the algorithm's performance in generating various 2-D realizations of conditional processes on large sampling grids.  相似文献   

Characterizing heterogeneous permeable media with spatial statistics and tracer data using sequential simulated annealing     

Akhil Datta-Gupta  Larry W. Lake  Gary A. Pope 《Mathematical Geology》1995,27(6):763-787

Characterizing heterogeneous permeable media using flow and transport data typically requires solution of an inverse problem. Such inverse problems are intensive computationally and may involve iterative procedures requiring many forward simulations of the flow and transport problem. Previous attempts have been limited mostly to flow data such as pressure transient (interference) tests using multiple observation wells. This paper discusses an approach to generating stochastic permeability fields conditioned to geologic data in the form of a vertical variogram derived from cores and logs as well as fluid flow and transport data, such as tracer concentration history, by sequential application of simulated annealing (SA). Thus, the method incorporates elements of geostatistics within the framework of inverse modeling. For tracer-transport calculations, we have used a semianalytic transit-time algorithm which is fast, accurate, and free of numerical dispersion. For steady velocity fields, we introduce a transit-time function which demonstrates the relative importance of data from different sources. The approach is illustrated by application to a set of spatial permeability measurements and tracer data from an experiment in the Antolini Sandstone, an eolian outcrop from northern Arizona. The results clearly reveal the importance of tracer data in reproducing the correlated features (channels) of the permeability field and the scale effects of heterogeneity.  相似文献   

Regional Seas and Sustainable Development Results of an International Workshop     

Josep Maria Bayona  Joan Albaigés 《GeoJournal》1995,36(4):416-416

Reports

Regional Seas and Sustainable Development Results of an International Workshop  相似文献   

Estimation for partially observed Markov processes     

M. E. Thompson  T. N. Kaseke 《Stochastic Hydrology and Hydraulics》1995,9(1):33-47

Many stochastic process models for environmental data sets assume a process of relatively simple structure which is in some sense partially observed. That is, there is an underlying process (X_n, n 0) or (X_t, t 0) for which the parameters are of interest and physically meaningful, and an observable process (Y_n, n 0) or (Y_t, t 0) which depends on the X process but not otherwise on those parameters. Examples are wide ranging: the Y process may be the X process with missing observations; the Y process may be the X process observed with a noise component; the X process might constitute a random environment for the Y process, as with hidden Markov models; the Y process might be a lower dimensional function or reduction of the X process. In principle, maximum likelihood estimation for the X process parameters can be carried out by some form of the EM algorithm applied to the Y process data. In the paper we review some current methods for exact and approximate maximum likelihood estimation. We illustrate some of the issues by considering how to estimate the parameters of a stochastic Nash cascade model for runoff. In the case of k reservoirs, the outputs of these reservoirs form a k dimensional vector Markov process, of which only the kth coordinate process is observed, usually at a discrete sample of time points.  相似文献   

合肥遥测台网地震速报系统     

刘东旺  黎捷 《地震地磁观测与研究》1995,16(6):27-34

论述了适用于遥测地震台网大震速报的一套计算机处理系统,系统设计以《全国遥测台网观测技术规范》和《近震分析》理论为依据,实现了数据输入,震相选择,数据处理,地震定位,震级计算,结果输出及贮存等多项功能,达到了快速确定地震三要素,提高速报速度和精度之目的,是一个较完善的,实用的速报系统。  相似文献