Distribution and inducibility of P-glycoprotein in the catfish: immunohistochemical detection using the mammalian C-219 monoclonal.     

K M Kleinow  A M Doi  A A Smith 《Marine environmental research》2000,50(1-5):313-317

Mounting evidence suggests that the P-glycoprotein (pgp) efflux pump may be a modulator of bioavailability and a mode of excretion for xenobiotics. Immunohistochemistry was utilized to examine the distribution and inducibility of a pgp like protein in catfish. Immunoreactivity to the MDR C-219 monoclonal antibody was noted primarily in bile canaliculi or bile preductules of the liver, discrete areas of the extratubular region of the kidney and the columnar epithelia of the intestine. Regional differences in pgp content were noted in the intestine with the distal region containing greater pgp levels than the proximal intestine. Dietary administration of vincristine, a prototypic pgp inducer and beta-naphthoflavone an Ah agonist resulted in induction of the C-219 immunoreactivity in the liver and the distal intestine. These results are consistent in location and inducibility with pgp like proteins and support a possible relationship to xenobiotic absorption and/or excretion in the catfish.  相似文献   

The Ediacaran radiogenic Sr isotope excursion in the Doushantuo Formation in the Three Gorges area,South China     

Yusuke Sawaki  Takeshi Ohno  Miyuki Tahata  Tsuyoshi Komiya  Takafumi Hirata  Shigenori Maruyama  Brian F. Windley  Jian Han  Degan Shu  Yong Li 《Precambrian Research》2010,176(1-4):46-64

The Ediacaran period was one of the most important times for the evolution of life. However, the scarcity of well-preserved outcrops of Ediacaran rocks still leaves ambiguity in decoding ambient surface environmental changes and biological evolution.The Ediacaran strata in South China are almost continuously exposed, comprise mainly carbonate rocks with subordinate black shales and sandstones, and they contain many fossils, suitable for study of environmental and biological changes in the Ediacaran. We conducted drilling through the Doushantuo Fm at four sites in the Three Gorges area to obtain continuous, fresh samples without surface alteration and oxidation. We analyzed ⁸⁷Sr/⁸⁶Sr and ⁸⁸Sr/⁸⁶Sr ratios of the fresh carbonate rocks, selected on the basis of microscopic observations and the geochemical signatures of Sr contents, Mn/Sr and Rb/Sr ratios, and δ¹⁸O values, with a multiple collector-inductively coupled plasma-mass spectrometer (MC-ICP-MS).The chemostratigraphy of the ⁸⁷Sr/⁸⁶Sr ratios of the drilled samples displays a smooth curve and two large positive shifts during Ediacaran time. The combination of the detailed chemostratigraphies of δ¹³C, δ¹⁸O and ⁸⁷Sr/⁸⁶Sr values and Mn and Fe contents enables us to decode the surface environmental changes and their causes in the Ediacaran. The first large positive excursion of ⁸⁷Sr/⁸⁶Sr occurred together with negative δ¹³C and positive δ¹⁸O excursions. The higher ⁸⁷Sr/⁸⁶Sr values indicate an enhancement of continental weathering, whereas the positive δ¹⁸O excursion suggests global cooling. Global regression due to global cooling enhanced the oxidative decay of exposed marine organic sediments and continental weathering. Accelerated influx of nutrients promoted primary productivity, resulting in oxidation of dissolved organic carbon (DOC), whereas active sulfate reduction due to a higher sulfate influx from the continents caused remineralization of the large DOC, both of which caused a negative δ¹³C anomaly. The 580 Ma Gaskiers glaciation accounts for the close correlation among the positive ⁸⁷Sr/⁸⁶Sr, negative δ¹³C and positive δ¹⁸O excursions.The second large positive shift of ⁸⁷Sr/⁸⁶Sr firstly accompanied a positive δ¹³C excursion, and continued through the Shuram δ¹³C negative excursion. The positive correlation of δ¹³C and ⁸⁷Sr/⁸⁶Sr values is consistent with an enhanced continental weathering rate due to continental collisions that built Trans-Gondwana mountain chains, and with a higher primary activity due to the enhancement of continental weathering and consequent higher nutrient contents in seawater. The accompanied increase in Mn and Fe contents implies a gradual decline of the seawater oxygen content due to more active aerobic respiration and oxidation of reductive materials flowing in the oceans. In the Shuram excursion, higher ⁸⁷Sr/⁸⁶Sr values and a transition from increase to decrease in Mn and Fe contents were accompanied by the large negative δ¹³C excursion. The higher ⁸⁷Sr/⁸⁶Sr values are the first compelling evidence for enhanced continental weathering, which was responsible for the large δ¹³C anomaly through the remineralization of the DOC by more active sulfate reduction due to a higher sulfate influx. Higher Mn and Fe contents in the early and middle stages of the excursion suggest a decline in the oxygen content of seawater due to oxidative decay of the DOC, whereas in the late stages the decrease in Mn and Fe contents is consistent with oceanic oxygenation.The emergence of Ediacara biota after the Gaskiers glaciation and the prosperity of the latest Ediacaran is concomitant with the formation of more radiogenic seawater with high ⁸⁷Sr/⁸⁶Sr values, suggesting that enhanced continental weathering, and the consequent higher influx of nutrients, played an important role in biological evolution.  相似文献   

A path that buys time to decide where to go     

Takeshi Shirabe 《International journal of geographical information science》2014,28(2):314-325

This paper considers the problem of planning a path in a circumstance where its origin is given, but its destination is not specified and is to be selected from among a set of candidate destinations during a trip. A situation like this may be experienced by a group of people who have different preferred destinations, as well as by an individual who is simply indecisive about where to go. To resolve such an uncertainty, one may stay at the origin until he decides on a destination, or choose to proceed on some path that does not overly deviate from a shortest path, whichever destination is eventually chosen, and make a decision on the way. The latter action is sensible when the risk of traveling longer is outweighed by the benefit of buying more time for a better destination decision. The problem of finding such a time-buying path is formulated and a simple algorithm is developed for its solution. Some extensions and applications are also discussed.  相似文献   

What controls equatorial Atlantic winds in boreal spring?     

Ingo Richter  Swadhin K. Behera  Takeshi Doi  Bunmei Taguchi  Yukio Masumoto  Shang-Ping Xie 《Climate Dynamics》2014,43(11):3091-3104

The factors controlling equatorial Atlantic winds in boreal spring are examined using both observations and general circulation model (GCM) simulations from the coupled model intercomparison phase 5. The results show that the prevailing surface easterlies flow against the attendant pressure gradient and must therefore be maintained by other terms in the momentum budget. An important contribution comes from meridional advection of zonal momentum but the dominant contribution is the vertical transport of zonal momentum from the free troposphere to the surface. This implies that surface winds are strongly influenced by conditions in the free troposphere, chiefly pressure gradients and, to a lesser extent, meridional advection. Both factors are linked to the patterns of deep convection. Applying these findings to GCM errors indicates, that, consistent with the results of previous studies, the persistent westerly surface wind bias found in most GCMs is due mostly to precipitation errors, in particular excessive precipitation south of the equator over the ocean and deficient precipitation over equatorial South America. Free tropospheric influences also dominate the interannual variability of surface winds in boreal spring. GCM experiments with prescribed climatological sea-surface temperatures (SSTs) indicate that the free tropospheric influences are mostly associated with internal atmospheric variability. Since the surface wind anomalies in boreal spring are crucial to the development of warm SST events (Atlantic Niños), the results imply that interannual variability in the region may rely far less on coupled air–sea feedbacks than is the case in the tropical Pacific.  相似文献   

Estimates of the turbulent kinetic energy budget in the oceanic convective boundary layer     

Takahiro Endoh  Takeshi Matsuno  Yutaka Yoshikawa  Eisuke Tsutsumi 《Journal of Oceanography》2014,70(1):81-90

The terms of the steady-state turbulent kinetic energy (TKE) budget in the oceanic convective boundary layer (CBL) are estimated by use of microstructure data obtained over the continental shelf of the East China Sea. The dissipation term is calculated from the micro-scale vertical shear of horizontal velocity measured directly using a freely-falling microstructure profiler, whereas the buoyancy flux and shear production terms are estimated indirectly by integrating vertically the one-dimensional conservation equation of density and by applying similarity theory, respectively. The transport term, calculated as the residual of the other three terms, vertically redistributes the TKE from the upper half of the CBL to the lower half, consistent with the TKE budgets in the atmospheric CBL and in shear-free and slightly-sheared CBLs simulated by large eddy-simulation models. The relatively large contribution of the transport term to the TKE budget shows that a local equilibrium form of the TKE equation is not appropriate for the TKE budget in the oceanic CBL.  相似文献   

Equatorial Atlantic variability and its relation to mean state biases in CMIP5   总被引：5，自引：4，他引：1  

Ingo Richter  Shang-Ping Xie  Swadhin K. Behera  Takeshi Doi  Yukio Masumoto 《Climate Dynamics》2014,42(1-2):171-188

Coupled general circulation model (GCM) simulations participating in the Coupled Model Intercomparison Project Phase 5 (CMIP5) are analyzed with respect to their performance in the equatorial Atlantic. In terms of the mean state, 29 out of 33 models examined continue to suffer from serious biases including an annual mean zonal equatorial SST gradient whose sign is opposite to observations. Westerly surface wind biases in boreal spring play an important role in the reversed SST gradient by deepening the thermocline in the eastern equatorial Atlantic and thus reducing upwelling efficiency and SST cooling in the following months. Both magnitude and seasonal evolution of the biases are very similar to what was found previously for CMIP3 models, indicating that improvements have only been modest. The weaker than observed equatorial easterlies are also simulated by atmospheric GCMs forced with observed SST. They are related to both continental convection and the latitudinal position of the intertropical convergence zone (ITCZ). Particularly the latter has a strong influence on equatorial zonal winds in both the seasonal cycle and interannual variability. The dependence of equatorial easterlies on ITCZ latitude shows a marked asymmetry. From the equator to 15°N, the equatorial easterlies intensify approximately linearly with ITCZ latitude. When the ITCZ is south of the equator, on the other hand, the equatorial easterlies are uniformly weak. Despite serious mean state biases, several models are able to capture some aspects of the equatorial mode of interannual SST variability, including amplitude, pattern, phase locking to boreal summer, and duration of events. The latitudinal position of the boreal spring ITCZ, through its influence on equatorial surface winds, appears to play an important role in initiating warm events.  相似文献   

Seismicity and magma supply rate of the 1998 failed eruption at Iwate volcano,Japan     

Takeshi Nishimura  Sadato Ueki 《Bulletin of Volcanology》2011,73(2):133-142

Iwate volcano, Japan, showed significant volcanic activity including earthquake swarms and volcano inflation from the beginning of 1998. A large earthquake of magnitude 6.1 hit the south-west of the volcano on September 3. Although a 1 km² fumarole field formed, blighting plants on the ridge in the western part of the volcano in the spring of 1999, no magmatic eruptions occurred. We reconcile the spatio-temporal distributions of volcanic pressure sources determined by previously reported studies in which GPS, strain and tilt data from dense geodetic station networks are analyzed (Miura et al. Earth Planet Space 52:1003–1008, 2000; Sato and Hamaguchi J Volcanol Geotherm Res 155:244–262, 2006). We calculate the magma supply rates from their results and compare them with the occurrence rates of volcanic earthquakes. The results show that the magma supply rates are almost constant or even decrease with time while the earthquake occurrence rate increases with time. This contrast in their temporal changes is interpreted to result from stress accumulation in the volcanic edifice caused by constant magma supply without effusion of magma to the surface. We further show that data showing slight acceleration in strain can be best explained by magma ascent at a constant velocity, and that there is no evidence for increased magma buoyancy resulting from gas bubble growth. This consideration supports the interpretation that the magma stayed at 2 km depth and horizontally migrated. These findings relating magma supply rate and seismicity to magma ascent process are clues to understanding why no magmatic eruption occurred at Iwate volcano in 1998.  相似文献   

Coseismic changes in the chemical composition of volcanic gases from the Owakudani geothermal area on Hakone volcano,Japan     

Takeshi Ohba  Yasushi Daita  Takeshi Sawa  Noriyasu Taira  Yusuke Kakuage 《Bulletin of Volcanology》2011,73(4):457-469

The chemical and isotopic compositions of volcanic gases at a borehole and a natural fumarole in the Owakudani geothermal area, Hakone volcano, Japan, have been repeatedly measured since 2001, when a seismic swarm occurred in the area. The CO₂/H₂O and CO₂/H₂S ratios were high in 2001. It increased in 2006 and again in 2008 when seismic swarms occurred beneath the geothermal area. The observed increases suggest the injection of CO₂- and SO₂-rich magmatic gas into the underlying hydrothermal reservoir, implying that the magmatic gas was episodically supplied to the hydrothermal system in 2006 and 2008. The earthquake swarms probably resulted from the injection of gas through the shallow crust accompanying the break of the sealing zone.  相似文献   

Geochemical evolution of historical lavas from Askja Volcano, Iceland: Implications for mechanisms and timescales of magmatic differentiation     

Takeshi Kuritani  Tetsuya Yokoyama  Hiroshi Kitagawa  Eizo Nakamura 《Geochimica et cosmochimica acta》2011,75(2):570-587

The mechanisms and the timescales of magmatic evolution were investigated for historical lavas from the Askja central volcano in the Dyngjufjöll volcanic massif, Iceland, using major and trace element and Sr, Nd, and Pb isotopic data, as well as ²³⁸U-²³⁰Th-²²⁶Ra systematics. Lavas from the volcano show marked compositional variation from magnesian basalt through ferrobasalt to rhyolite. In the magnesian basalt-ferrobasalt suite (5-10 wt% MgO), consisting of lavas older than 1875 A.D., ⁸⁷Sr/⁸⁶Sr increases systematically with increasing SiO₂ content; this suite is suggested to have evolved in a magma chamber located at ∼600 MPa through assimilation and fractional crystallization. On the other hand, in the ferrobasalt-rhyolite suite (1-5 wt% MgO), including 1875 A.D. basalt and rhyolite and 20th century lavas, ⁸⁷Sr/⁸⁶Sr tends to decrease slightly with increasing SiO₂ content. It is suggested that a relatively large magma chamber occupied by ferrobasalt magma was present at ∼100 MPa beneath the Öskjuvatn caldera, and that icelandite and rhyolite magmas were produced by extraction of the less and more evolved interstitial melt, respectively, from the mushy boundary layer along the margin of the ferrobasalt magma chamber, followed by accumulation of the melt to form separate magma bodies. Ferrobasalt and icelandite lavas in the ferrobasalt-rhyolite suite have a significant radioactive disequilibrium in terms of (²²⁶Ra/²³⁰Th), and its systematic decrease with magmatic evolution is considered to reflect aging, along with assimilation and fractional crystallization processes. Using a mass-balance model in which simultaneous fractional crystallization, crustal assimilation, and radioactive decay are taken into account, the timescale for the generation of icelandite magma from ferrobasalt was constrained to be <∼3 kyr which is largely dependent on Ra crystal-melt partition coefficients we used.  相似文献   

Hydrogen isotopic substitution of solid methylamine through atomic surface reactions at low temperatures: A potential contribution to the D/H ratio of methylamine in molecular clouds     

Yasuhiro Oba  Takeshi Chigai  Yoshihiro Osamura  Naoki Watanabe  Akira Kouchi 《Meteoritics & planetary science》2014,49(1):117-132

We experimentally studied hydrogen (H)–deuterium (D) substitution reactions of solid methylamine (CH₃NH₂) under astrophysically relevant conditions. We also calculated the potential energy surface for the H–D substitution reactions of methylamine isotopologues using quantum chemical methods. Despite the relatively large energy barrier of more than 18 kJ mol^?1, CH₃NH₂ reacted with D atoms to yield deuterated methylamines at 10 K, suggesting that the H–D substitution reaction proceeds through quantum tunneling. Deuterated methylamines reacted with H atoms as well. On the basis of present results, we propose that methylamine has potential for D enrichment through atomic surface reactions on interstellar grains at very low temperatures in molecular clouds. D enrichment would occur in particular in the methyl group of methylamine.  相似文献