参附注射液建立自发性高血压病大鼠肝阳上亢证模型的研究          下载免费PDF全文

周梦  杨文丽  刘晓庆 《应用海洋学学报》2018,34(12):120-122

目的：探讨参附注射液建立自发性高血压大鼠（SHR）模型的可能性。方法：将30只3月龄SPF级健康雄性自发性高血压大鼠称重，随机分为SHR组，附子汤组，参附注射液低、中、高剂量组，每组6只。各组采用对应药物灌胃进行模型制备，另取同品系同周龄雄性魏-凯二氏大鼠（WKY）6只作为正常对照组（WKY组）。观察参附注射液对SHR大鼠24h饮水量、易激惹程度、痛阈、睑结膜充血及收缩压的影响。结果：附子汤组及参附注射液中、高剂量组造模后均出现了易激惹程度增高、睑结膜充血程度增高、饮水量增多、痛阈降低、收缩压升高等肝阳上亢的表现，与WKY组及SHR组比较，差异有统计学意义（P<0.05)，表明造模成功。结论：参附注射液可以制备新型高血压肝阳上亢证模型，但是具体造模机制以及造模药物用量需待进一步探讨确定。  相似文献   

Retrieving volume FeO and TiO_2 abundances of lunar regolith with CE-2 CELMS data using BPNN method     

Cai Liu  Hong-Yan Sun  Zhi-Guo Meng  Yong-Chun Zheng  Yu Lu  Zhan-Chuan Cai  Jin-Song Ping  Alexander Gusev  Shuo Hu 《天文和天体物理学研究(英文版)》2019,(5)

The volume FeO and TiO_2 abundances(FTAs) of lunar regolith can be more important for understanding the geological evolution of the Moon compared to the optical and gamma-ray results. In this paper, the volume FTAs are retrieved with microwave sounder(CELMS) data from the Chang'E-2 satellite using the back propagation neural network(BPNN) method. Firstly, a three-layered BPNN network with five-dimensional input is constructed by taking nonlinearity into account. Then, the brightness temperature(TB) and surface slope are set as the inputs and the volume FTAs are set as the outputs of the BPNN network.Thereafter, the BPNN network is trained with the corresponding parameters collected from Apollo, Luna,and Surveyor missions. Finally, the volume FTAs are retrieved with the trained BPNN network using the four-channel TBderived from the CELMS data and the surface slope estimated from Lunar Orbiter Laser Altimeter(LOLA) data. The rationality of the retrieved FTAs is verified by comparing with the Clementine UV-VIS results and Lunar Prospector(LP) GRS results. The retrieved volume FTAs enable us to re-evaluate the geological features of the lunar surface. Several important results are as follows. Firstly, very-low-Ti(1.5 wt.%) basalts are the most spatially abundant, and the surfaces with TiO_2 5 wt.% constitute less than 10% of the maria. Also, two linear relationships occur between the FeO abundance(FA) and the TiO_2 abundance before and after the threshold, 16 wt.% for FA. Secondly, a new perspective on mare volcanism is derived with the volume FTAs in several important mare basins, although this conclusion should be verified with more sources of data. Thirdly, FTAs in the lunar regolith change with depth to the uppermost surface,and the change is complex over the lunar surface. Finally, the distribution of volume FTAs hints that the highlands crust is probably homogeneous, at least in terms of the microwave thermophysical parameters.  相似文献   

风和径流量对长江口缺氧影响的数值模拟   总被引：1，自引：1，他引：0  

郑静静  刘桂梅  高姗  李云  李志杰 《海洋学报》2018,40(9):1-17

受自然和人类活动的影响，海洋缺氧现象日益严重，威胁着海洋生态环境，海洋缺氧问题已经引起了人们的广泛关注。本文应用区域海洋模式并耦合生态模式，对东海的生态系统进行了数值模拟和分析研究。与观测数据比较显示，该模型能较好地模拟长江口外生态变量的分布趋势。另外本文通过设置不同敏感性实验，探讨风和径流量对长江口底层缺氧现象的影响，结果分析表明，风和径流量对长江口外缺氧区的形成有显著的影响。径流量变化虽然对长江口外缺氧区的季节变化影响并不显著，但是对缺氧区域面积却存在显著的影响。径流量增加，水体层化增强，表层叶绿素浓度增加，最终导致缺氧区域范围扩展；径流量减小，水体层化减弱，表层叶绿素浓度减小，缺氧区域范围缩小。风向和风速的改变不仅影响长江口外缺氧区的季节变化，还影响缺氧区域面积。  相似文献   

两株南极枝孢霉属真菌Cladosporium sp.NJF4和NJF6的次级代谢产物研究          下载免费PDF全文

常俊男  田晓清  樊成奇  黄金昌  陆亚男  韩清华 《极地研究》2020,32(1):60-67

南极因其独特的自然环境成为潜在、重要的微生物资源库,是产生新型生物活性物质和先导化合物菌株的潜在种源地,南极微生物正在成为创新药物研究新的重要资源。虽然近年来对南极微生物次级代谢产物的研究逐渐增加,但与温带和热带微生物研究相比仍处于初级阶段。对从南极普里兹湾海洋沉积物中获得的两株枝孢霉属真菌Cladosporium sp. NJF4和NJF6进行次级代谢产物分离及结构鉴定,获得20个化合物。化合物结构类型包括甾醇(1)、倍半萜类(7—8)、生物碱类(9—14)、二酮哌嗪(2—5、15—17)、芳香酸(6、18—19)等,其中倍半萜类(7—8)为首次从枝孢霉属真菌中分离得到,以上研究将为丰富南极微生物次级代谢产物库奠定一定的研究基础。  相似文献   

青藏高原隆升的非线性动态有限元仿真研究   总被引：7，自引：4，他引：3  

杨红心  王乘  张秋文  郑文衡 《大地测量与地球动力学》2002,22(2):75-81

根据青藏高原的地质特征建立分析模型，采用3维动态有限元方法，在计算仿真板块速度场的基础上，计算在青藏高原的隆升过程中该地区地壳岩石的等效应力和位移随时间的变化，计算仿真得到的速度场与1998年GPS观测的速度场吻合良好；与过去一贯的假设相反，计算结果反映出地壳应力场不是静态的，而是此起彼伏，不断变化的，应力值最大且变化最剧烈的地区在克什米尔地区、鄂尔多斯地区和鲜水河－小江断裂带，与地震多发区域吻合。  相似文献   

“BASS 300 PARACOM”: a “model” underwaterparametric communication system     

Coates  R.F.W. Ming Zheng Liansheng Wang 《Oceanic Engineering, IEEE Journal of》1996,21(2):225-232

Parametric transduction offers valuable advantages for underwater acoustic communications. Perhaps the most significant benefit is the fact that high directivity is achieved by means of a physically small transmit transducer. This feature may, ultimately, be employed to permit long-range, low-frequency communication using a compact source. The high directivity is desirable to combat multipath propagation and to achieve data communications in water which is shallow by comparison with range. A real-time, high data-rate “model” differential phase shift keying (DPSK) communication system has been constructed and demonstrated. This system uses parametric transduction, with a 300-kHz primary frequency and a 50-kHz secondary frequency. Experimental results show that the system can be employed to combat multipath propagation in shallow water and can achieve high data-rate text and color image transmission at 10 and 20 kb s^-1 for 2-DPSK and 4-DPSK, respectively, through a transmission bandwidth of 10 kHz. The “model” system was developed to confirm performance predictions for a future, operational long-range link employing a 50-kHz primary frequency and a 5-kHz secondary frequency  相似文献   

Dust supply from river floodplains: the case of the lower Huang He (Yellow River) recorded in a loess–palaeosol sequence from the Mangshan Plateau     

Maarten A. Prins  Hongbo Zheng  Kay Beets  Simon Troelstra  Patrick Bacon  Ilse Kamerling  Wouter Wester  Martin Konert  Xiangtong Huang  Wang Ke  Jef Vandenberghe 《第四纪科学杂志》2009,24(1):75-84

The Mangshan Plateau is located on the south bank of the Huang He (Yellow River) just west of the city of Zhengzhou, well outside the Loess Plateau in central China. Mixing models of the grain‐size data indicate that the loess deposits are mixtures of three loess components. Comparison of the mixing model with existing models established for a series of loess–palaeosol sequences from the Loess Plateau indicates that the Mangshan loess has been supplied from a proximal dust source, the Huang He floodplain, during major dust outbreaks. The high accumulation rates, the composition of the loess components, and especially the high proportions of a sandy loess component support this. Owing to the exceptionally high accumulation rates, the Mangshan grain size, magnetic susceptibility and carbonate records provide a high‐resolution archive of environmental and climate change. Copyright © 2008 John Wiley & Sons, Ltd.  相似文献   

地壳对海洋潮汐的响应   总被引：2，自引：2，他引：0  

郑文衡  王乘  何振  牛安福 《大地测量与地球动力学》2002,22(2):41-46

应用三维动态有限元方法研究了中国北部地区的地壳对邻近的渤海与黄海海平面变化的响应。虽然此应力场过于微弱不足以引发地震，但发现应力集中的位置及应力场变化较大的位置恰好与某些现代地震的震中一致。这一结果表明研究地壳对广泛分布的载荷的响应对研究区域地震构造是有帮助的。  相似文献   

人造导引星自适应光学的倾斜决定问题     

范承玉  宋正方 《中国天文和天体物理学报》1997,(1)

本文从Zernike多项式出发 ,推导了激光导引星自适应光学倾斜校正的非等晕性方差 ,以其方差 1rad2 为判据 ,导出了倾斜等晕角的表达式 ,得出了与Parenti和Sasiela推导的相同的结果  相似文献   

LAST GLACIATION AND MAXIMUM GLACIATION IN THE QINGHAI-XIZANG (TIBET) PLATEAU: A CONTROVERSY TO M. KUHLE,S ICE SHEET HYPOTHESIS   总被引：1，自引：0，他引：1  

施雅风  郑本兴  李士杰 《中国地理科学(英文版)》1992,(4)

Since the late 1950's, many Chinese scientists have explored the remains of the Quaternary glaciation in the Qinghai-Xizang (Tibet) Plateau and its surrounding mountains. In the main, 3-4 glaciations have been recognized. The largest one occurred in the Late Middle Pleistocene with piedmont glaciers, ice caps and trellis valley glaciers in many high peak regions. But here is no evidence of a unified ice sheet covering the whole plateau as described by M. Kuhle. Due to the further uplifting of the Himalayas and Qinghai-Xizang Plateau the climate became progressively drier, diminishing the extension of glaciers during the Late Pleistocene. The elevation of the snow line during the Last Glaciation was about 4,000 m on the south, east and northeast edges of the plateau and ascended to 5500 m on the hinder northwest of the plateau. The thermal effect of the big plateau massif, the sharp increase of aridity from the southeast rim to the northwest inland area and the abrupt decrease of precipitation during the  相似文献