A whole life cycle assessment on effects of waterborne PBDEs on gene expression profile along the brain-pituitary-gonad axis and in the liver of zebrafish     

Han XB  Lei EN  Lam MH  Wu RS 《Marine pollution bulletin》2011,63(5-12):160-165

Polybrominated diphenyl ethers (PBDEs) are now found ubiquitously in the aquatic environment and biota, and there is a growing concern that PBDEs may disrupt endocrine systems, leading to reproductive impairments of aquatic animals. In our study, zebrafish (Danio rerio) were exposed to the 5 ng/L, 1 μg/L and 50 μg/L of DE-71 for the duration of the whole life cycle (120 days, from eggs to adults). The expression of selected genes along the brain-pituitary-gonadal (BPG) axis and liver, and the levels of plasma sex hormones were examined. In male fish, up-regulation of GnRH in brain, FSHβ and LHβ in pituitary, FSH-receptor, LH-receptor, and CYP19a in testis was clearly evident, while down-regulation of CYP11a and 3β-HSD was found in testis. In female fish, a 2.4-fold up-regulation of 3β-HSD was found in ovary upon exposure to 50 μg/L of DE-71. GnRH in brain, FSHβ and LHβ in pituitary were also up-regulated, while ERβ, TH and TPH in brain and GnRH-receptor in pituitary were significantly down-regulated. Hepatic ERα, AR and VTG in males were all down-regulated, while hepatic ERα and AR in female were up-regulated. Serum estradiol (E2) was reduced in both male and female upon exposure to DE-71, while significant increases in serum testosterone (T) and 11-keto-testosterone (11-KT) were only found in male but not female fish. The ratio of T/E2 as well as the ratio of 11-KT/E2 in male fish increased in a dose-dependent manner upon exposure to DE-71. Our overall results showed that whole life exposure of DE-71 altered the expression of regulatory genes and receptors at all three levels of the BPG axis in zebrafish, and the responses are sex dependent. The observed disruption of GnRH and GtHs can be further related to the subsequent disruption in both levels and balance sex steroid hormones.  相似文献   

VTI介质中准P波方程叠前逆时深度偏移   总被引：3，自引：0，他引：3       下载免费PDF全文

韩令贺  何兵寿  张会星 《地震学报》2011,33(2):209-218

根据具有垂直对称轴的横向各向同性（VTI）介质中的一阶准P波方程,导出了该方程在交错网格中逆时延拓的高阶有限差分格式,给出了其稳定性条件,采用完全匹配层吸收边界条件解决边界反射问题,分别应用下行波最大能量法和归一化互相关成像条件, 实现了VTI介质中准P波方程的叠前逆时深度偏移．各向异性Marmousi模型的试算结果表明,VTI介质准P波方程叠前逆时深度偏移算法不受地下构造倾角和介质横向速度变化的限制,对复杂模型具有良好的成像能力;应用归一化互相关成像条件能得到更好的成像效果．对比该模型的各向异性和各向同性逆时偏移剖面表明,在各向异性地区采集的纵波数据用各向异性偏移算法理论上能得到更好的成像结果．   相似文献   

Uncertainty assessment for watershed water quality modeling: A Probabilistic Collocation Method based approach     

Yi Zheng  Weiming WangFeng Han  Jing Ping 《Advances in water resources》2011,34(7):887-898

Watershed water quality models are increasingly used in management. However, simulations by such complex models often involve significant uncertainty, especially those for non-conventional pollutants which are often poorly monitored. This study first proposed an integrated framework for watershed water quality modeling. Within this framework, Probabilistic Collocation Method (PCM) was then applied to a WARMF model of diazinon pollution to assess the modeling uncertainty. Based on PCM, a global sensitivity analysis method named PCM-VD (VD stands for variance decomposition) was also developed, which quantifies variance contribution of all uncertain parameters. The study results validated the applicability of PCM and PCM-VD to the WARMF model. The PCM-based approach is much more efficient, regarding computational time, than conventional Monte Carlo methods. It has also been demonstrated that analysis using the PCM-based approach could provide insights into data collection, model structure improvement and management practices. It was concluded that the PCM-based approach could play an important role in watershed water quality modeling, as an alternative to conventional Monte Carlo methods to account for parametric uncertainty and uncertainty propagation.  相似文献   

IASPEI宽频带面波震级的测定方法研究     

韩雪君  马延路  刘瑞丰 《地震地磁观测与研究》2011,32(3):9-12

根据IASPEI新推荐的宽频带面波震级Ms(BB)计算方法,设计自动测定Ms(BB)软件,可以对中国地震台网中心接收的约1 000个地震台站资料进行自动处理,利用宽频带资料快速测定Ms(BB).可以在几分钟内使用所有宽频带资料进行计算,所得结果比较稳定、可靠.  相似文献   

干旱区绿洲气候变化及影响——以新疆石河子为例     

蒲云锦  韩春光 《内蒙古气象》2011,(2):23-26,34

文章以新疆石河子气象局1961—2008年年均气温、年降水量和年均日照观测资料为研究对象,运用趋势拟合方法、Morlet小波和Yamamoto方法分析其趋势变化、周期及突变特性。结果表明:48年中,石河子年平均气温和年降水量呈递增趋势,年均日照呈微弱递减趋势,均有一定的周期性,在不同的年份发生了突变,最后分析了气候变化对农业生产的影响。  相似文献   

气象灾害应急管理能力评价   总被引：5，自引：0，他引：5  

韩颖  岳贤平  崔维军 《气象科技》2011,39(2):242-246

建立气象灾害应急能力评价指标体系对增强应对气象灾害管理能力和提高灾害的应急响应能力有重要的意义。从系统理论的角度出发,基于气象灾害应急管理的特征和结构的分析,运用层次分析法原理,构建了由气象灾害预警防御能力、政府组织能力、支撑保障能力3个1级指标和15个2级指标组成的气象灾害应急管理能力的评价指标体系,可为提高气象灾害应急管理能力和防灾减灾提供科学依据。  相似文献   

Long-term simulations of the sulfur concentrations over the China, Japan and Korea: A model comparison study     

Cheol-Hee Kim  Lim-Seok Chang  Jeong-Soo Kim  Fan Meng  Mizuo Kajino  Hiromasa Ueda  Yuanhang Zhang  Hye-Young Son  Youjiang He  Jun Xu  Keiichi Sato  Chang-Keun Song  Soo-Jin Ban  Tatsuya Sakurai  Zhiwei Han  Lei Duan  Suk-Jo Lee  Shang-Gyoo Shim  Young Sunwoo  Tae-Young Lee 《Asia-Pacific Journal of Atmospheric Sciences》2011,47(4):399-411

Three comprehensive acid deposition models were used to simulate the sulfur concentrations over northeast Asia over the period covering entire year of 2002, and discussed the aggregated uncertainties and discrepancies of the three models. The participating models are from the countries participating in the project of Longrange Transboundary Air Pollutants in Northeast Asia (LTP): China, Japan and Korea. The Eulerian Model-3/CMAQ (by China), Regional Air Quality Model (RAQM, by Japan), and Comprehensive Acid Deposition Model (CADM, by Korea) were employed by each country with common emissions data established by the administrative agencies of China, Japan and Korea. The episodic simulation results between 1 to 15, March 2002 are also presented, during which aircraft measurements were carried out over the Yellow sea. The episodic results show both a wide short-term variability in simulations against measurements, and maximum concentration differences of 3～5 times among the three models, requiring that further attention before confidence among the three models can be claimed for short-term simulations. However, the year-long cumulative simulations showed almost the same general features, with lower aggregated uncertainties between the three models, produced by the long term integration over northeast Asia.  相似文献   

The Wenchuan Earthquake (May 12, 2008), Sichuan Province,China, and resulting geohazards   总被引：19，自引：5，他引：14  

Peng Cui  Xiao-Qing Chen  Ying-Yan Zhu  Feng-Huan Su  Fang-Qiang Wei  Yong-Shun Han  Hong-Jiang Liu  Jian-Qi Zhuang 《Natural Hazards》2011,56(1):19-36

On Monday, May 12, 2008, a devastating mega-earthquake of magnitude 8.0 struck the Wenchuan area, northwestern Sichuan Province, China. The focal mechanism of the earthquake was successive massive rock fracturing 15 km in depth at Yingxiu. Seismic analysis confirms that the major shock occurred on the Beichuan–Yingxiu Fault and that aftershocks rapidly extended in a straight northeast–southeast direction along the Longmenshan Fault zone. Fatalities approaching a total of 15,000 occurred, with a significant number resulting from four types of seismically triggered geohazards—rock avalanches and landslides, landslide-dammed lakes (“earthquake lakes”), and debris flows. China Geological Survey has identified 4,970 potentially risky sites, 1,701 landslides, 1,844 rock avalanches, 515 debris flows, and 1,093 unstable slopes. Rock avalanches and landslides caused many fatalities directly and disrupted the transportation system, extensively disrupting rescue efforts and thereby causing additional fatalities. Landslide-dammed lakes not only flooded human habitats in upstream areas but also posed threats to potentially inundated downstream areas with large populations. Debris flows become the most remarkable geohazards featured by increasing number, high frequency, and low triggering rainfall. Earthquake-triggered geohazards sequentially induced and transformed to additional hazards. For example, debris flows occurred on rock avalanches and landslides, followed by landslide-dammed lakes, and then by additional debris flows and breakouts of the landslide-dammed lakes and downstream flooding. Earthquake-induced geohazards occurred mainly along the fault zone and decreased sharply with distance from the fault. It can be anticipated that post-earthquake geohazards, particularly for debris flows, will continue for 5–10 years and even for as long as 20 years. An integrated strategy of continuing emergency response and economic reconstruction is required. The lesson from Wenchuan Earthquake is that the resulted geohazards may appear in large number in active fault regions. A plan for geohazard prevention in the earthquake-active mountainous areas is needed in advance.  相似文献   

现代油藏描述关键技术          下载免费PDF全文

王志章  韩海英 《地学前缘》2011,18(5):296-302

现代油藏描述提倡勘探开发一体化,真正实现测井与地震信息匹配,实现静态信息与动态信息结合,最终由定性走向定量。重点阐述了现代油藏描述中,通过集成高分辨率的岩石物理数据、中分辨率的测井数据及低分辨率的地震数据,采用储层自动划分对比及储层结构分析技术、沉积微相自动识别技术、波形差异分析法预测高产气区技术对不同勘探开发阶段、不...  相似文献   

An extensive erosion surface of a strongly deformed limestone bed in the Gushan and Chaomidian formations (late Middle Cambrian to Furongian), Shandong Province,China: Sequence–stratigraphic implications     

Jitao Chen  S.K. Chough  Zuozhen Han  Jeong-Hyun Lee 《Sedimentary Geology》2011,233(1-4):129-149

In order to understand sequence development and sea-level fluctuations during the late Middle Cambrian to early Furongian on the North China epeiric platform, the present study focuses on a unique, subtle erosion surface of an extensive (approx. 100 km), strongly deformed limestone bed in the uppermost part of the Gushan Formation, Shandong Province, China. The Gushan Formation and the overlying Chaomidian Formation consist mainly of shales and a variety of carbonates that were deposited in subtidal environments (e.g., deep subtidal, shallow subtidal, shoreface/shoal, subtidal microbial flat, and restricted platform interior). Three third-order depositional sequences (S1–3) are identified, each of which comprises a thin transgressive systems tract (TST) and a relatively thick highstand systems tract (HST). Each sequence is bounded by a drowning unconformity (SB1), a subaerial unconformity (SB2), or a surface of submarine erosion (SB3). The upper sequence boundary (SB2) of sequence 1 (S1) is represented by a subtle erosion surface of an extensive, deformed limestone bed with a wide variety of soft-sediment deformation structures (e.g., lime mudstone breccias, chaotic wacke-packstone laminae and fragments, homogenized oolites, and clastic dykes), and is overlain by small sporadic microbial buildups and an extensive bioclastic grainstone bed. The deformed limestone was formed during early diagenesis by differential deformation processes (brecciation, liquefaction/fluidization, and injection) which were most likely induced by pore-water overpressure during the period of rapid sea-level fall. Despite the lack of subaerial exposure features (e.g., paleokarst, paleosol, etc.), the characteristics of the erosion surface (cutting well-lithified sediment below), the missing of a significant geological record (the Prochuangia biozone), and the worldwide correlatable positive carbon isotope excursion collectively indicate that the erosion surface developed under conditions of subaerial exposure after contemporaneous marine cementation of the deformed sediment. The missing of the Prochuangia biozone is most likely due to non-deposition at a subaerial hiatal surface. The erosion surface was submerged as a result of subsequent rise in sea level, where sporadic microbial buildups formed under suitable conditions. Freshly deposited, winnowed, shell-dominated transgressive lag deposits (containing Chuangia trilobite fragments, brachiopod shells, and abundant glauconite grains) formed with continued rise in sea level, which became, in turn, overlain by shale-dominated facies. The unique combination of the subtle erosion surface (sensu stricto a subaerial unconformity) and the underlying deformed limestone bed provides an important criterion for recognizing the subtle changes in relative sea level on shallow epeiric platforms.  相似文献