PI3K/Akt pathway is involved in the activation of RAW 264.7 cells induced by hydroxypropyltrimethyl ammonium chloride chitosan     

YANG Yue  XING Rong’e  LIU Song  QIN Yukun  LI Kecheng  YU Huahua  LI Pengcheng 《海洋湖沼学报（英文）》2020,(3):834-840

We previously demonstrated that 2-hydroxypropyltrimethyl ammonium chloride chitosan(HACC)promoted the production of nitric oxide(NO)and proinflammatory cytokines by activating the mitogen-activated protein kinases(MAPK)and Janus kinase(JAK)/STAT pathways in RAW 264.7 cells,indicating good immunomodulatory activity of HACC.In this study,to further investigate the immunomodulatory mechanisms of HACC,we determined the roles of phosphatidylinositol 3-kinase(PI3K)/Akt,activating protein(AP-1)and nuclear factor kappa B(NF-κB)in HACC-induced activation of RAW 264.7 cells by the western blotting.The results suggest that HACC promoted the phosphorylation of p85 and Akt.Furthermore,c-Jun and p65 were also increased after the treatment of RAW 264.7 cells with HACC,indicating the translocation of NF-κB and AP-1 from cytoplasm to nucleus.In addition,as scanning electron microscopy(SEM)analysis shows,the cell morphology changed after HACC treatment.These findings indicate that HACC activated MAPK,JAK/STAT,and PI3K/Akt signaling pathways dependent on AP-1 and NF-κB activation in RAW 264.7 cells,ultimately leading to the increase of NO and cytokines.  相似文献   

Opportunities to search for extraterrestrial intelligence with the FAST     

Di Li  Vishal Gajjar  Pei Wang  Andrew Siemion  Zhi-Song Zhang  Hai-Yan Zhang  You-Ling Yue  Yan Zhu  Cheng-Jin Jin  Shi-Yu Li  Sabrina Berger  Bryan Brzycki  Jeff Cobb  Steve Croft  Daniel Czech  David DeBoer  Julia DeMarines  Jamie Drew  J.Emilio Enriquez  Nectaria Gizani  Eric J.Korpela  Howard Isaacson  Matthew Lebofsky  Brian Lacki  David H.E.MacMahon  Morgan Nanez  Chen-Hui Niu  Xin Pei  Danny C.Price  Dan Werthimer  Pete Worden  Yunfan Gerry Zhang  Tong-Jie Zhang  FAST Collaboration 《天文和天体物理学研究(英文版)》2020,(5):193-204

The discovery of ubiquitous habitable extrasolar planets,combined with revolutionary advances in instrumentation and observational capabilities,has ushered in a renaissance in the search for extraterrestrial intelligence(SETI).Large scale SETI activities are now underway at numerous international facilities.The Five-hundred-meter Aperture Spherical radio Telescope(FAST)is the largest single-aperture radio telescope in the world,and is well positioned to conduct sensitive searches for radio emission indicative of exo-intelligence.SETI is one of the five key science goals specified in the original FAST project plan.A collaboration with the Breakthrough Listen Initiative was initiated in 2016 with a joint statement signed both by Dr.Jun Yan,the then director of National Astronomical Observatories,Chinese Academy of Sciences(NAOC),and Dr.Peter Worden,Chairman of the Breakthrough Prize Foundation.In this paper,we highlight some of the unique features of FAST that will allow for novel SETI observations.We identify and describe three different signal types indicative of a technological source,namely,narrow band,wide-band artificially dispersed and modulated signals.Here,we propose observations with FAST to achieve sensitivities never before explored.For nearby exoplanets,such as TESS targets,FAST will be sensitive to an EIRP of 1.9×1011 W,well within the reach of current human technology.For the Andromeda Galaxy,FAST will be able to detect any Kardashev type II or more advanced civilization there.  相似文献   

Seasonal variation of mesoscale eddy intensity in the global ocean     

Yongcan Zu  Yue Fang  Shuangwen Sun  Libao Gao  Yang Yang  Guijun Guo 《海洋学报(英文版)》2024,(1):48-58

Mesoscale eddies are a prominent oceanic phenomenon that plays an important role in oceanic mass transport and energy conversion. Characterizing by rotational speed, the eddy intensity is one of the most fundamental properties of an eddy. However, the seasonal spatiotemporal variation in eddy intensity has not been examined from a global ocean perspective. In this study, we unveil the seasonal spatiotemporal characteristics of eddy intensity in the global ocean by using the latest satellite-alti...  相似文献   

The Beila Ophiolite from the Bangong-Nujiang Suture Zone, Northern Tibetan Plateau     

ZHAI Qingguo  TANG Yue  HU Peiyuan  XIAO Xuchang  WANG Haitao 《《地质学报》英文版》2017,91(Z1):51-51

The Beila ophiolite is located in the middle part of the Bangong-Nujiang suture zone,northern Tibetan plateau.It is a complete ophiolite suite,and plays a key role in understanding the evolution of the Bangong-Nujiang suture zone,as well as the Meso-Tethys Ocean.The Beila ophiolite was composed of peridotite,serpentinite,gabbro,pillow basalt,and minor rodingite.Peridotites comprisemainlymedium–tocoarse–grained serpentinized harzburgites and minor plagioclase-bearing lherzolites and dunites.There are some felsic-ultramafic dykes within the peridotite and they are mainlypegmatoidal pyroxenites,coarse to fine-grained gabbros,and diabases.Gabbros included isotropic and cumulate gabbros,and they commonly contain minor pegmatoidal gabbros veins.Pillow basalts and basaltic andesites overlaid on the margin of the serpentinized peridotites.Rodingite occurs as lenses and/or dykes within the host serpentinized peridotites.Zircon SHRIMP U–Pb dating for two rodingite samples yielded the ages ranging from172 to 164 Ma.Whole-rock geochemical and zircon Hf isotopic data show that the Beila ophiolite shows SSZ-type ophiolite affinity.Finally,we suggest that the Beila ophiolite was generated in an initial subduction process at the middle Jurassic(164–172 Ma).  相似文献   

The Spatiotemporal Distribution Characteristics of Cloud Types and Phases in the Arctic Based on CloudSat and CALIPSO Cloud Classification Products     

Yue SUN  Huiling YANG  Hui XIAO  Liang FENG  Wei CHENG  Libo ZHOU  Weixi SHU  Jingzhe SUN 《大气科学进展》2024,(2):310-324

The cloud type product 2B-CLDCLASS-LIDAR based on CloudSat and CALIPSO from June 2006 to May 2017 is used to examine the temporal and spatial distribution characteristics and interannual variability of eight cloud types(high cloud, altostratus, altocumulus, stratus, stratocumulus, cumulus, nimbostratus, and deep convection) and three phases(ice,mixed, and water) in the Arctic. Possible reasons for the observed interannual variability are also discussed. The main conclusions are as follows:(1) Mo...  相似文献   

Chronological Constraints on Late Paleozoic Collision in the Southwest Tianshan Orogenic Belt,China: Evidence from the Baleigong Granites     

HUO Hailong  CHEN Zhengle  ZHANG Qing  HAN Fengbin  ZHANG Wengao  SUN Yue  YANG Bin  TANG Yanwen 《《地质学报》英文版》2019,93(5):1188-1204

The Baleigong granites, located in the western part of the southwestern Tianshan Orogen(Kokshanyan region, China), records late Paleozoic magmatism during the late stages of convergence between the Tarim Block and the Central Tianshan Arc Terrane. We performed a detailed geochronological and geochemical study of the Baleigong granites to better constrain the nature of collisional processes in the Southwest Tianshan Orogen. The LA-ICP-MS U-Pb zircon isotopic analyses indicate that magmatism commenced in the early Permian(～282 Ma). The granite samples, which are characterized by high contents of SiO_2(67.68–69.77 wt%) and Al_2O_3(13.93–14.76 wt%), are alkali-rich and Mg-poor, corresponding to the high-K calc-alkaline series. The aluminum saturation index(A/CNK) ranges from 0.93 to 1.02, indicating a metaluminous to slightly peraluminous composition. Trace element geochemistry shows depletions in Nb, Ta, and Ti, a moderately negative Eu anomaly(δEu=0.40–0.56), enrichment in LREE, and depletion in HREE((La/Yb)_N=7.46–11.78). These geochemical signatures are characteristic of an I-type granite generated from partial melting of a magmatic arc. The I-type nature of the Baleigong granites is also supported by the main mafic minerals being Fe-rich calcic hornblende and biotite. We suggest that the high-K, calc-alkaline I-type granitic magmatism was generated by partial melting of the continental crust, possibly triggered by underplating by basaltic magma. These conditions were likely achieved in a collisional tectonic setting, thus supporting the suggestion that closure of the South Tianshan Ocean was completed prior to the Permian and was followed(in the late Paleozoic) by collision between the Tarim Block and the Central Tianshan Arc Terrane.  相似文献   

Magma Mixing of the Late Paleozoic Tayuan Complex in the Xing’an Block     

HE Yue  GE Wenchun  HE Zhonghu  YANG Hao  DONG Yu  JI Zheng  ZHAO Di  JING Yan 《《地质学报》英文版》2019,93(Z2):23-24

Mesozoic ophiolites crop out discontinuously in the Indo‐Myanmar Ranges in NE India and Myanmar, and represent the remnants of the Neotethyan oceanic lithosphere. These ophiolites in the Indo‐Myanmar Ranges are the southern continuation of the Neotethyan ophiolites occurring along the Yarlung Zangbo Suture Zone in southern Tibet farther northwes, as indicated by their coeval crystallization ages and geochemical compositions. The Kalaymyo ophiolite is located in the central part of the Indo‐Myanmar Ranges (Myanmar). The Kalaymyo ophiolite are composed of olivine (Fo = 89.8–90.5), orthopyroxene (En86‐91Wo1‐4Fs8‐10; Mg#=89.6–91.9), clinopyroxene (En46‐49Wo47‐50Fs3‐5; Mg# = 90.9–93.6) and spinel (Mg# = 67.1–78.9; Cr# = 13.5–31.5), and have relatively homogeneous whole‐rock compositions with Mg# of 90.1–90.8 and SiO2 (41.5–43.65 wt.%), Al₂O₃ (1.66–2.66 wt.%) and CaO (1.45–2.67 wt.%) contents. They display Light Rare Earth Element (LREE)‐depleted chondrite‐normalized REE patterns and show a slight enrichment from Pr to La. The Kalaymyo peridotites are characterized by Pd‐enriched chondrite‐normalized PGE patterns with superchondritic (Pd/Ir)_CN ratios (1.15–2.36). Their calculated oxygen fugacities range between QFM–0.57 and QFM+0.90. These features collectively suggest that the Kalaymyo peridotites represent residual upper mantle rocks after low to moderate degrees (5–15%) of partial melting at a mid‐ocean‐ridge environment. The observed enrichment in LREE and Pd was a result of their reactions with enriched MORB‐like melts, percolating through these already depleted, residual peridotites. The Kalaymyo and other ophiolites in the Indo‐Myanmar Ranges hence represent mid‐ocean ridge–type Tethyan oceanic lithosphere derived from a downgoing plate and accreted into a westward migrating subduction–accretion system along the eastern margin of India.  相似文献   

Magma Mixing and Tectonic Implications of Hailin Pluton at the Southeastern Margin of Songnen–Zhangguangcai Range Massif, Northeast China     

ZHAO Di  GE Wenchun  YANG Hao  DONG Yu  JI Zheng  HE Yue  JING Yan 《《地质学报》英文版》2019,93(Z2):59-60

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河南新密一荥巩矿区煤矸石中有害微量元素的溶出     

宋志敏  杨萍Yue 《煤田地质与勘探》2002,30(4):14-15

淋溶是有害微量元素从煤或煤矸石中析出后污染环境的重要途径。本文在对河南新密－荥巩矿区煤矸石淋溶实验的基础上，研究了有害微量元素从煤矸石中淋溶析出的浓度及淋溶过程中pH值的变化规律，探讨了不同淋溶实验方法对有害微量元素溶出的影响，并对有害微量元素溶出的环境意义进行了讨论。  相似文献   

复杂山地低信噪比地震资料处理方法   总被引：1，自引：0，他引：1  

张亚斌  杜贤  孔剑冰  李贺 《物探与化探》2005,29(1):34-36,40

宜阳复杂山地地震资料的特点是静校正量大,信噪比低。针对该区的特点,在资料处理中采用建立全区统一浮动基准面与折射静校正方法解决静校正问题;运用叠前去噪技术、目标速度分析、DMO技术、优化迭代叠加技术、F-X域信号增强去噪技术,同时,优化处理流程,精选处理参数,取得了明显效果。  相似文献