α-Glucosidase Inhibitory Activities of Lutein and Zeaxanthin Purified from Green Alga Chlorella ellipsoidea     

QI Jia  KIM Sang Moo 《中国海洋大学学报(英文版)》2018,(4)

α-Glucosidase inhibitors are used therapeutically to treat type-2 diabetes mellitus. Through a bioassay-guided fractionation technique, three carotenoids,(all-E)-lutein,(all-E)-zeaxanthin and(9-Z)-zeaxanthin, were purified from the green alga Chlorella ellipsoidea, in which(all-E)-lutein and(9-Z)-zeaxanthin had potent α-glucosidase inhibitory activity. IC_(50) values of(all-E)-lutein and(9-Z)-zeaxanthin were 70 and 53.5 μmol L~(-1) against Saccharomyces cerevisiae α-glucosidase, respectively, with non-competitive inhibition. In addition, IC_(50) values of(9-Z)-zeaxanthin against Bacillus stearothermophilus and rat-intestinal α-glucosidase were 805.1 and 671.2 μmol L~(-1), respectively. The K_i values of(all-E)-lutein and(9-Z)-zeaxanthin against S. cerevisiae α-glucosidase were 78.1 and 16.5 μmol L~(-1), respectively. Therefore, C. ellipsoidea carotenoids might be utilized as a novel candidate to prevent type-2 diabetes mellitus related disorders in food and medical industry.  相似文献   

朝鲜半岛南部三维地壳速度结构成像   总被引：9，自引：2，他引：7       下载免费PDF全文

李清河  张元生  So Gu KIM 《地球物理学报》2007,50(4):1073-1081

对多震相走时层析成像方法进行改进和优化, 使用朝鲜半岛陆地和近海的地震记录, 对朝鲜半岛南部(345°N～39°N,125°E～130°E)进行地震波走时反演, 获得了本研究区的三维速度结构成像结果.分析了沉积层、基底、上地壳、康腊面、下地壳和莫霍面的特征.研究了不同地质区的深部结构的主要差别、主要断裂特征、 海陆交界的地壳特征等.可以发现京畿山地与沃川褶皱带、太白山褶皱带、临津江褶皱带深部结构的差异尤为明显.  相似文献   

Meso-Cenozoic basin evolution in northern Korean Peninsula     

PAK Hyon Uk  LYANG To Jun  HYON Yun Su  KIM Gyong Chol 《东北亚地学研究》2009,12(2):80-86

In the Korean Peninsula the Meso-Cenozoic basins were mainly formed due to fault block and block movement. The Mesozoic fracture structures correspond basically to modem large rivers in direction. Such faults were usually developed to rift and formed lake-type tectonic basin, such as the Amrokgang-, Taedonggang-, Ryesonggang-, Hochongang-, Jangphari-, Susongchon-, Pujon-, and Nampho basins. The Mesozoic strata are considered to be divided into the Lower Jurassic Taedong System, Upper Jurassic Jasong System, Upper Jurassic-early Lower Cretaceous Taebo System, and the Upper Cretaceous-Paleocene （ Chonjaebong, Hongwon, Jaedok Series）. The Cenozoic block movement succeeded the Mesozoic fault block movement. The Kilju-Myongchon Graben and Tumangang Basin, etc, are the basins related to the fault zones developed from the Oligocene to Miocene. In addition, the Tertiary basins were formed in many areas in the Miocene （e. g. Sinhung, Oro, Hamhung, Yonghung, Anbyon, Cholwon, etc）. The Cenozoic sedimentation occurred mainly from the late Oligocene to Miocene. The Kilju-Myongchon Graben was the fore deep connected to the sea and the basins inclined in the Chugaryong Fault Zone are intramountain basins. Therefore, coal-beating beds and clastic rocks in the intramountain basins and rare marine strata and terrigenous clastic rocks are main sedimentary sequences in the Cenozoic.  相似文献   

Hydrogeochemical Characteristics of Acid Mine Drainage around the Abandoned Youngdong Coal Mine in Korea     

Hyo–Taek CHON  Ju–Yong KIM  Si–Young CHOI 《Resource Geology》1999,49(2):113-120

Abstract: To determine the geochemical characteristics of the Imgok creek impacted by acid mine drainage (AMD) generated from the abandoned Youngdong coal mine in Korea, chemical analyses of water samples and precipitates and the geochemical modelling of the precipitates were conducted. Acid mine drainage drained from the mine adit and coal refuse piles shows a low pH, high conductivity and high concentrations of Fe, Al, SO₄ and heavy metals such as Co, Cu, Ni and Zn. In the Imgok creek, the concentrations of heavy metals and major cations besides Fe are decreased by dilution, but concentrations of Fe are decreased by the formation of precipitates as well as dilution. From the results of geochemical modelling, goethite is oversaturated, and schwertmannite is the most stable solid phase in the Imgok creek. Yellowish red Fe-precipitates collected at the Imgok creek are recognized as amorphous or poorly crystallized minerals from XRD patterns and Fe_ox/Fe_totratios, and as containing chemically bonded SO₄ and OH by an IR analysis. The mole ratios of Fe/S in these precipitates, which are determined by EPMA, are 5. 1 and 6. 1.  相似文献   

Protective effects of Ecklonia cava extract on the toxicity and oxidative stress induced by hair dye in in-vitro and in-vivo models     

OH Jae-Young  RYU Bo-Mi  YANG Hye-Won  KIM Eun-A  LEE Jung-Suck  JEON You-Jin 《海洋湖沼学报（英文）》2019,(3):909-917

Oxidative hair dyes containingρ-phenylenediamine(PPD)are reported to induce an allergic reaction by promoting oxidative stress when absorbed through the skin.Despite the associated risk,these hair dyes remain popular owing to their convenience and sharpness of color.This makes it important to minimize the cytotoxicity and oxidative stress induced by PPD-containing hair dyes.Ecklonia cava extract has been evaluated in different studies for its protective effects against external stress in fibroblasts and keratinocytes.Our study was aimed at using in-vitro and in-vivo models to investigate the extract’s effects on cytotoxicity of and oxidative stress induced by PPD-containing hair dyes.Analysis of CIEL*a*b*Color space was first used to determine the range of E.cava extract that would not interfere with the coloring ability of the dye upon addition.Subsequently,the set ranges of E.cava extract(5% and 7%)were added to the hair dye and their toxicity assessed by evaluating the viability of fibroblasts and keratinocytes.The effects on developmental phenotypes and induction of oxidative stress by hair dye were evaluated and compared with those of hair dyes containing different contents of E.cava extract using an in-vivo zebrafish model.Our results showed that E.cava extract in hair dye could significantly decrease the cytotoxicity and levels of oxidative stress caused by hair dyes containing PPD in both in-vitro and in-vivo models.These results suggest that the addition of 7% E.cava extract to 250μg/mL hair dye does not interfere with the coloring ability of the dye while showing significant protective eff ects against the hair dye.The study proposes that the use of E.cava extract as an adduct to hair dyes containing PPD reduces the cytotoxicity and oxidative stress induced by these hair dyes.  相似文献   

Numerical simulation of a short flexible pipe subject to forced motion and vortex-induced vibration   总被引：2，自引：0，他引：2  

CHEN Zhengshou  KIM Wu-joan  CHOI Yoon-rak 《海洋学报(英文版)》2009,28(6):70-83

A series of numerical simulations about a small scale(aspect ratio:63.2) flexible pipe undergoing forced harmonious oscillation and vortex-induced vibration(VIV) have been taken into account.The wake hydrodynamics and pipe deformation were accomplished by ANSYS MFX solution strategy designed for fluid-structure interaction(FSI) problem with well-performed LES model.The configuration of structured mesh,multi-domain design,different mesh stiffness admeasured by User Fortran ensured that the numerical task was competent to deal with large deformation related to this case.The introduction of instantaneous amplitude definition and modeless component decomposition method(Chen and Kim,2008) was helpful to reveal much more information from modal analysis.Most results from numerical simulation are generally consistent with those from model test(Choi and Hong,2000) via the comparison between them.As supplementary to model test,visualization of the vortex wake was also provided.It has been proved that the forced oscillation doesn't only excite a complicated dumbbell-like wake pattern around the outer thimble,but also results in inner flow inside the PVC pipe.The velocity of the inner flow increases with the frequency of forced oscillation.  相似文献   

Meso-Cenozo ic basin evolution in northern Korean Peninsula          下载免费PDF全文

PAK Hyon Uk  LYANG To Jun  LIU Yongjiang  HYON Yun Su  KIM Gyong Chol 《世界地质(英文版)》2009,12(2):80-86

In the Korean Peninsula the Meso-Cenozoic basins were mainly formed due to fault block and block movement. The Mesozoic fracture structures correspond basically to modern large rivers in direction. Such faults were usually developed to rift and formed lake-type tectonic basin, such as the Amrokgang-, Taedonggang-, Ryesonggang-, Hochongang-, Jangphari-, Susongchon-, Pujon-, and Nampho basins. The Mesozoic strata are considered to be divided into the Lower Jurassic Taedong System, Upper Jurassic Jasong System, Upper Jurassic－early Lower Cretaceous Taebo System, and the Upper Cretaceous－Paleocene (Chonjaebong, Hongwon, Jaedok Series) . The Cenozoic block movement succeeded the Mesozoic fault block movement. The Kilju-Myonchon Graben and Tumangang Basin, etc, are the basins related to the fault zones developed from the Oligocene to Miocene. In addition, the Tertiary basins were formed in many areas in the Miocene ( e. g. Sinhung, Oro, Hamhung, Yonghung, Anbyon, Cholwon, etc) . The Cenozoic sedimentation occurred mainly from the late Oligocene to Miocene. The Kilju-Myongchon Graben was the fore deep connected to the sea and the basins inclined in the Chugaryong Fault Zone are intramountain basins. Therefore, coal-bearing beds and clastic rocks in the intramountain basins and rare marine strata and terrigenous clastic rocks are main sedimentary sequences in the Cenozoic.  相似文献   

Observation and Numerical Simulations with Radar and Surface Data Assimilation for Heavy Rainfall over Central Korea     

Ji-Hyun HA  Hyung-Woo KIM  Dong-Kyou LEE 《大气科学进展》2011,28(3):573-590

This study investigated the impact of multiple-Doppler radar data and surface data assimilation on forecasts of heavy rainfall over the central Korean Peninsula;the Weather Research and Forecasting(WRF) model and its three-dimensional variational data assimilation system(3DVAR) were used for this purpose. During data assimilation,the WRF 3DVAR cycling mode with incremental analysis updates(IAU) was used. A maximum rainfall of 335.0 mm occurred during a 12-h period from 2100 UTC 11 July 2006 to 0900 UTC 12 July 2006.Doppler radar data showed that the heavy rainfall was due to the back-building formation of mesoscale convective systems(MCSs).New convective cells were continuously formed in the upstream region,which was characterized by a strong southwesterly low-level jet(LLJ).The LLJ also facilitated strong convergence due to horizontal wind shear,which resulted in maintenance of the storms.The assimilation of both multiple-Doppler radar and surface data improved the accuracy of precipitation forecasts and had a more positive impact on quantitative forecasting(QPF) than the assimilation of either radar data or surface data only.The back-building characteristic was successfully forecasted when the multiple-Doppler radar data and surface data were assimilated.In data assimilation experiments,the radar data helped forecast the development of convective storms responsible for heavy rainfall,and the surface data contributed to the occurrence of intensified low-level winds.The surface data played a significant role in enhancing the thermal gradient and modulating the planetary boundary layer of the model,which resulted in favorable conditions for convection.  相似文献   

基于遗传算法局部方向梯度的古墓葬圆形土壤标志检测     

KIM Wonsok  聂跃平  朱建峰  邓飚  于丽君  刘芳  高华光 《遥感学报》2013,17(3):671-679

中国新疆北部古墓葬目标在Google Earth上显示为两大类:一类是斑点型,另一类是圆环型,两类的边界都比较模糊。自动提取这些古墓葬目标比较困难,针对这一问题,提出了一种基于遗传算法局部方向梯度的圆形检测算法。该方法采用局部方向梯度,并且基于计算边缘方向梯度的主分量实现,因此该方法能适用各种边缘特征,遗传算法的加入能够提高在圆形不连贯、多圆相交等情况下圆形自动检测的鲁棒性。本文选取新疆北部作为试验区域,结果表明本文方法与传统的基于霍夫变换的圆形检测算法相比,能适应多特征的圆形边缘,而且不用设定自动检测中的阈值,更加智能化,自动化。  相似文献   

A Review of: “The GIS book”     

KIM FARTHING 《International journal of geographical information science》2013,27(1):139-141

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