基于网络药理学-分子对接探索大黄牡丹汤治疗大肠癌的作用机制          下载免费PDF全文

梁子成  文璐  陈泓秀 《应用海洋学学报》2021,37(10):177

目的：利用网络药理学-分子对接技术探索经方大黄牡丹汤治疗大肠癌的作用机制。方法：通过TCMSP、TCMID数据库获得大黄牡丹汤药物成分,通过PubChem、Swisstarget prediction数据库获得药物成分对应靶点,分析GSE113513芯片获得差异基因,随即获取大黄牡丹汤与大肠癌的共同靶点。利用R、Cytoscape、Autodock软件进行PPI、GO、KEGG、分子对接等分析。结果：获得大黄牡丹汤靶点561个,大肠癌差异基因1227个,共同靶点71个。共同靶点的通路富集分析显示主要与PPAR、p53等信号通路相关,Reactome机制分析显示大黄牡丹汤治疗大肠癌主要通过影响信号转导、免疫系统、疾病等产生作用,分子对接结果显示大肠癌核心靶点与大黄牡丹汤主要成分亲和力较好,能够有效自由结合。结论：经方大黄牡丹汤可通过多层次、多途径、多靶点发挥对大肠癌的治疗作用。  相似文献   

伍劲华运用半夏秫米汤治疗不寐经验          下载免费PDF全文

马春成  王嘉丽  伍劲华 《应用海洋学学报》2018,34(8):21-23

从睡眠的机制、不寐的病因病机、半夏秫米汤的理法方药以及个人经验等多方面系统阐述了伍劲华主任医师应用半夏秫米汤治疗不寐的学术思想和临证心得。不寐的关键在于阳不入阴,故治疗时用半夏秫米汤加减,以决渎壅塞,通经络,调和阴阳,引阳入阴。临证时常用薏苡仁代替秫米,加煅磁石助半夏之功,百合及合欢花调和阴阳。  相似文献   

Seasonal variations of phytoplankton diversity in the Coleroon coastal waters, southeast coast of India   总被引：1，自引：0，他引：1  

Thillai Rajasekar K  Rajkumar M  SUN Jun  Ashok Prabu V  Perumal P 《海洋学报(英文版)》2010,29(5):97-108

The results of an investigation carried out during June 2005 to May 2007 on physico-chemical parameters,species composition and community structure of phytoplankton including Chlorophyll a(Chl-a) at the Coleroon coastal waters(Southeast coast of India) are reported.Air and surface water temperatures(°C) varied from 25.1 to 30.1 and from 24.5 to 28.5 respectively.Salinity values varied from 6 to 28.5 and the pH ranged between 7.0 and 8.3.Variation in dissolved oxygen content was from 3.1 to 7.5 mg/dm-3 while the light extinction coefficient values(LEC) ranged between 3.1 and 10.1 cm.The ranges of inorganic nutrients(μmol/dm-3) viz.,nitrate,nitrite,phosphate and silicate were 10.1-23.4,1.2-8.9,0.2-3.1 and 55-125,respectively.The ranges of Chlorophyll a(μg/dm-3) values was 2.0-7.5.Presently,124 phytoplankton species representing different classes viz:Bacillariophyceae(77),Dinophyceae(19),Cyanophyceae(15),Chlorophyceae(10) and Chrysophyceae(3) were recorded.The phytoplankton cell abundance varied from 0.290 to 111.662 cells/cm-3,with peak diversity(3.38 bits/ind.) during summer season.The maximum abundance was found during summer season coinciding with the stable hydrographical conditions.The seasonal distribution and abundance of phytoplankton are discussed in relation to hydrographical parameters.Canonical Correspondence Analysis(CCA) was applied in this paper for discriminating environmental factors having effect on phytoplankton community at species level.Coleroon coastal water is subjected to long term fluctuations in physico-chemical parameters depending upon the seasonal tidal amplitude and freshwater influx resulting in a continuous exchange of organic,inorganic,plant and animal matters.  相似文献   

我与齐齐哈尔市的半生缘     

张书田 《黑龙江国土资源》2009,(12):34-34

五一节前夕,春光明媚。为了迎接一年一度的“6·25”国土日,我去齐齐哈尔市国土资源局和部分县局采访耕地保护工作。  相似文献   

Methodology for the diagnostics of soil polygenesis on the basis of macro- and micromorphological studies     

T.V.Tursina 《山地科学学报》2009,6(2):125-131

A methodology for studying soil polygenesis and lithological homogeneity of soil profiles is suggested. This methodology is particularly important for mountain soils, where the lithological heterogeneity of the soil profiles created by denudation and accumulation processes is often observed. The methodology includes several stages： （a） the study of the lithological homogeneity/ heterogeneity of soil profiles by field and laboratory methods, （b） the stage-by-stage macro-, meso-, micro-, and submicromorphological analyses of soil profiles with additional use of the methods of neighboring sciences, and （e） the subdivision of soil features into the groups of recent and inherited （relict） features. In the latter group, the subgroups of lithorelict features inherited from the parent material and pedorelict features inherited from the previous stages of soil formation can be distinguished. Two major models of soil polygenesis are suggested. Simple models describe the soils, in which new features appear due to the changes in the environmental conditions in the course of soil evolution. Complex models describe the soils, in which such changes are combined with deposition of new portions of sediments onto the soil surface with the development of buried soil horizons （the synlithogenie pedogenesis）. The models of continuous and discontinuous synlithogenic pedogenesis can be further distinguished. It is argued that the micromorphological method applied to the studies on soil mierofabrics, microforms of soil humus, soil porosity, coatings, and various pedo- and lithorelict features yields valuable information on polygenetic soils.  相似文献   

对虾传染性肌肉坏死病研究进展     

闫冬春  Kathy F. J. Tang  Donald V. Lightner 《海洋科学》2009,33(9):89-91

对虾传染性肌肉坏死病(infectious myonecrosis,IMN)最初于2002年8月爆发于巴西Piaui州的凡纳滨对虾(Litopenaeus vannamei)养殖场,并很快在巴西东北沿岸蔓延开来,目前已传至亚洲.2004年,经美国亚利桑那大学(University of Arizona)水产病害实验室研究,该病为一种新的对虾疾病,根据其症状,暂定名为传染性肌肉坏死病.  相似文献   

Distribution of the nonlinear random ocean wave period     

侯一筠  李明杰  宋贵霆  司广成  齐鹏  胡珀 《中国海洋湖沼学报》2009,27(4):919-923

Because of the intrinsic difficulty in determining distributions for wave periods, previous studies on wave period distribution models have not taken nonlinearity into account and have not performed well in terms of describing and statistically analyzing the probability density distribution of ocean waves. In this study, a statistical model of random waves is developed using Stokes wave theory of water wave dynamics. In addition, a new nonlinear probability distribution function for the wave period is presented with the parameters of spectral density width and nonlinear wave steepness, which is more reasonable as a physical mechanism. The magnitude of wave steepness determines the intensity of the nonlinear effect, while the spectral width only changes the energy distribution. The wave steepness is found to be an important parameter in terms of not only dynamics but also statistics. The value of wave steepness reflects the degree that the wave period distribution skews from the Cauchy distribution, and it also describes the variation in the distribution function, which resembles that of the wave surface elevation distribution and wave height distribution. We found that the distribution curves skew leftward and upward as the wave steepness increases. The wave period observations for the SZFII-1 buoy, made off the coast of Weihai (37°27.6′ N, 122°15.1′ E), China, are used to verify the new distribution. The coefficient of the correlation between the new distribution and the buoy data at different spectral widths (ν=0.3−0.5) is within the range of 0.968 6 to 0.991 7. In addition, the Longuet-Higgins (1975) and Sun (1988) distributions and the new distribution presented in this work are compared. The validations and comparisons indicate that the new nonlinear probability density distribution fits the buoy measurements better than the Longuet-Higgins and Sun distributions do. We believe that adoption of the new wave period distribution would improve traditional statistical wave theory.  相似文献   

误差椭圆在精密工程测量中的应用研究   总被引：2，自引：0，他引：2       下载免费PDF全文

卞和方  张书毕  李益斌  王波 《海洋测绘》2009,29(1):49-51

进行精密工程测量时,要根据工程的要求和现场的具体条件,通过精度分析拟定切实可行的观测方案,采用合适的测量方法来获得最可靠的成果。据此探讨了误差椭圆在精密工程测量中的应用。  相似文献   

附有限制条件的间接平差秩亏时解法初探          下载免费PDF全文

秦永宽  黄声享  张书毕 《海洋测绘》2009,29(1):7-9

在附有限制条件的间接平差的应用中,若所列观测方程中实际用到的未知参数的个数少于所选参数的总数u时,就会出现法方程系数阵秩亏的问题。为了解决此问题,在理论公式推导的基础上,给出了一种新的解决方法,并结合算例进行了验证。  相似文献   

北冰洋hinlopen—yermak滑坡以及发生海啸可能性的数值模拟     

Maarten  Vanneste  Carl  B.  Harbitz  Fabio  V.  De  Blasio  Sylfest  Glimsdal  Jurgen  Mienert  Anders  Elverhoi  杨丽娟 《海洋地质》2009,(1)

从有冰川供给的斯瓦尔巴特群岛北部陆缘采集到的多波束资料揭示出一个大型海底滑坡-Hinlopen—Yemaak滑坡的详细地形特征。有许多个几百米高的平坦断崖,其中位于横穿陆架的Hirdopen深海槽口的最大的滑坡后壁的高度超过了1400m。除了有明显的压缩外,地震剖面上还见有半透声体,表明块体运移沉积物可能是重塑或液化的碎屑流堆积物,这些堆积物在一些地方有几百米厚。在大范围的块体运移沉积物的外缘,许多漂浮的块体从半透明的沉积单元中突起,  相似文献