Urban agglomeration is caused by the continuous acceleration of the urbanization process in China. Studying the expansion of construction land can not only know the changes and development of urban agglomeration in time, but also obtain the great significance of the future management. In this study, taking Changsha-Zhuzhou-Xiangtan (Chang-Zhu-Tan) urban agglomeration in Hunan province as a study area, Landsat images from 1995 to 2014 and Autologistic-CLUE-S model simulation data were used. Moreover, several factors including gravity center, direction, distance and landscape index were considered in the analysis of the expansion. The results revealed that the construction area increased by 132.18%, from 372.28 km² in 1995 to 864.37 km² in 2014. And it might even reach 1327.23 km² in 2023. Before 2014, three cities had their own respective and discrete development directions. However, because of the integration policy implementation in 2008, the Chang-Zhu-Tan began to gather, the gravity center moved southward after 2014, and the distance between cities decreased, which was in line with the development plan of urban expansion. The research methods and results were relatively reliable, and these results could provide some reference for the future land use planning and spatial allocation in the urbanization process of Chang-Zhu-Tan urban agglomeration.