The Japanese medaka (Oryzias latipes) model: applicability for investigating the immunosuppressive effects of the aquatic pollutant benzo[a]pyrene (BaP)     

Carlson EA  Li Y  Zelikoff JT 《Marine environmental research》2002,54(3-5):565-568

Despite the fact that BaP is a carcinogen, mammalian immunosuppressant, and ubiquitous aquatic pollutant, knowledge regarding the effects of BaP on the immune system of fish is still lacking. To begin to fill this gap, studies were conducted in medaka to examine the effects and mechanisms by which BaP exposure might alter host immunocompetence. Fish, exposed by IP injection of BaP (2-600 microg/g BW), were examined after 48 h for effects upon immune function and CYP1A expression/activity. Benzo[a]pyrene, at a concentration below that which increased levels of CYPIA expression/activity (2 microg BaP/g BW) suppressed lymphocyte proliferation. Concentrations of BaP at 20 and 200 microg/g BW. suppressed antibody-forming cell (AFC) numbers, superoxide production, and host resistance against bacteria. In contrast, exposure to the low affinity aryl hydrocarbon receptor (AhR) agonist, benzo[e]pyrene (BeP), neither induced CYP1A expression nor altered immune function. Given the lack of immunosuppressive effects produced by BeP, and the fact that exposure to the AhR antagonist (and CYP1A inhibitor) alpha-naphthoflavone (ANF) ameliorated the suppressive effects of BaP upon AFC numbers, the AhR pathway (including CYP1A-mediated production of reactive BaP metabolites) appears important in mediating BaP-induced immunotoxicity in fish, as in mammals. In the past, the medaka has proven a successful model for assessing carcinogenic agents. These studies have demonstrated its utility for also determining the immunosuppressive effects of an important aquatic contaminant.  相似文献   

White-light promoted degradation of leucopterin and related pteridines dissolved in seawater, with evidence for involvement of complexation from major divalent cations of seawater     

Arthur F. Landymore  Naval J. Antia 《Marine Chemistry》1978,6(4):309-325

The photochemical instability of several related pteridines in seawater was investigated by aseptic incubation of solutions at 20–22°C under illumination from cool-white light of intensity 6 kerg cm⁻² sec⁻¹, and the chemical changes were spectrophotometrically monitored. All the pteridines showed markedly accelerated degradation from this illumination relative to their behaviour in total darkness.Pterin and lumazine were degraded very slowly with zero-order reaction kinetics, while the other pteridines photolysed rapidly (according to first-order kinetics) with decomposition rates increasing in the order dioxylumazine (2,4,6,7-tetrahydroxypteridine) < leucopterin < isoxanthopterin < xanthopterin < oxylumazine (2,4,6-trihydroxypteridine). Excepting leucopterin and dioxylumazine, the photolysis rates were attributable to the pH of seawater and not its salt content; this was also the case with oxylumazine which required the salt content of seawater for decomposition in darkness. Leucopterin and dioxylumazine (both 6,7-dihydroxylated pteridines) gave evidence of complexation with the major divalent cations (Ca²⁺, Mg²⁺) of seawater, by virtue of which their photolytic degradation rates were enhanced to magnitudes obtained in pH-10 buffer without seawater. It is proposed that such complexation produces structural forms of these pteridines analogous to their normal ionic forms at pH 10–12.The photolysis of the 6-hydroxylated pteridines (xanthopterin, oxylumazine) proceeded via intermediate formation of their corresponding 7-hydroxylated derivatives (leucopterin, dioxylumazine).  相似文献   

Coastal Habitat Use and Residency of Juvenile Atlantic Sharpnose Sharks (Rhizoprionodon terraenovae)     

John K. Carlson  Michelle R. Heupel  Dana M. Bethea  Lisa D. Hollensead 《Estuaries and Coasts》2008,31(5):931-940

Coastal habitat use and residency of a coastal bay by juvenile Atlantic sharpnose sharks, Rhizoprionodon terraenovae, were examined by acoustic monitoring, gillnet sampling, and conventional tag–recapture. Acoustic monitoring data were used to define the residency and movement patterns of sharks within Crooked Island Sound, Florida. Over 3 years, sharks were monitored for periods of 1–37 days, with individuals regularly moving in and out of the study site. Individual sharks were continuously present within the study site for periods of 1–35 days. Patterns of movement could not be correlated with time of day. Home range sizes were typically small (average?=?1.29 km²) and did not vary on a yearly basis. Gillnet sampling revealed that juvenile Atlantic sharpnose sharks were present in all habitat types found within Crooked Island Sound, and peaks in abundance varied depending on month within a year. Although telemetry data showed that most individuals remained within the study site for short periods of time before emigrating, conventional tag–recapture data indicates some individuals return to Crooked Island Sound after extended absences (maximum length?=?1,352 days). Although conventional shark nursery theory suggests small sharks remain in shallow coastal waters to avoid predation, juvenile Atlantic sharpnose sharks frequently exited from protected areas and appear to move through deeper waters to adjacent coastal bays and estuaries. Given the high productivity exhibited by this species, the benefit gained through a nursery that reduces predation may be limited for this species.  相似文献   

The restricted problem of n+ν bodies     

Arthur L. Whipple  Victor Szebehely 《Celestial Mechanics and Dynamical Astronomy》1984,32(2):137-144

The simplest, conventional, and original form of the circular restricted problem of three bodies is briefly described in sidereal and synodic systems using dimensional and non-dimensional variables. This dynamical system is generalized to n2 primary bodies (from n=2) with masses M_i, 1in, interacting with arbitrary force laws (instead of only gravitational forces). The number of bodies of small mass mM_i not perturbing the primaries is increased from =1 to 1 where 1 and the minor bodies are allowed to interact with one another under arbitrary force laws. While the minor bodies (m) do not affect the motions of the primaries (M_i), the primaries influence the motions of the minor bodies with arbitrary force laws.For the case where n=2, 1, and only gravitational forces act on the system, an integral of the system is derived. It is shown that the energy integral of the general problem of N bodies and the Jacobian integral of the classical restricted problem of three bodies are limiting cases of this integral. The role of the integral in bounding the motion of the minor bodies is discussed. Several applications of this system are given.  相似文献   

Io's sodium emission cloud and the voyager 1 encounter     

B.A. Goldberg  Yu. Mekler  R.W. Carlson  T.V. Johnson  D.L. Matson 《Icarus》1980,44(2):305-317

Io's neutral sodium emission cloud was monitored during the period of Voyager 1 encounter from two independent ground-based sites. Observations from Table Mountain Observatory verified the continued existence of the “near-Io cloud” (d < 1.5 × 10⁵ km, for 4πI > 1 kR; R denotes Rayleigh) while those from Wise Observatory showed a deficiency in the weaker emission at greater distances from Io. The sodium cloud has been monitored from both observatories for several years. These and other observations demonstrate that the behavior of the cloud is complex since it undergoes a variety of changes, both systematic and secular, which can have both time and spatial dependencies. The cloud also displays some characteristics of stability. Table Mountain images and high-dispersion spectra (resolution $\text{～0.2}\text{A}\text{?}$) indicate that the basic shape and intensity of the “near cloud” have remained relatively constant at least since imaging observations began in 1976. Wise Observatory low-dispersion spectra (resolution $\text{～1}\text{A}\text{?}$) which have been obtained since 1974 demonstrate substantial variability of the size and intensity of the “far cloud” (d ? 1.5 × 10⁵ km) on a time scale of months or less. Corresponding changes in the state of the plasma associated with the Io torus are suggested, with the period of Voyager 1 encounter represented as a time of unusually high plasma temperature and/or density. Dynamic models of the sodium cloud employing Voyager 1 plasma data provide a reasonable fit to the Table Mountain encounter images. The modeling assumptions of anisotropic ejection of neutral sodium atoms from the leading, inner hemisphere of Io with a velocity distribution characteristic of sputtering adequately explain the overall intensity distribution of the “near cloud”. During the Voyager 1 encounter period there appeared a region of enhanced intensity projecting outward from Io's orbit and inclined to the orbital plane. This region is clearly distinguished from the sodium emission normally aligned with the plane of Io's orbit. The process responsible for this phenomenon is not yet understood. Similar but less pronounced features are also present in several Table Mountain images obtained over the past few years.  相似文献   

A study of the background corona near solar minimum   总被引：2，自引：0，他引：2  

Kuniji Saito  Arthur I. Poland  Richard H. Munro 《Solar physics》1977,55(1):121-134

The white light coronagraph data from Skylab is used to investigate the equatorial and polarK andF coronal components during the declining phase of the solar cycle near solar minimum. Measurements of coronal brightness and polarization brightness product between 2.5 and 5.5R during the period of observation (May 1973 to February 1974) lead to the conclusions that: (1) the equatorial corona is dominated by either streamers or coronal holes seen in projections on the limb approximately 50% and 30% of the time, respectively; (2) despite the domination by streamers and holes, two periods of time were found which were free from the influences of streamers or holes (neither streamers nor holes were within 30° in longitude of the limb); (3) the derived equatorial background density model is less than 15% below the minimum equatorial models of Newkirk (1967) and Saito (1970); (4) a spherically symmetric density model for equatorial coronal holes yields densities one half those of the background density model; and (5) the inferred brightness of theF-corona is constant to within ±10% and ±5% for the equatorial and polar values, respectively, over the observation period. While theF-corona is symmetric at 2R it begins to show increasing asymmetry beyond this radius such that at 5R the equatorialF-coronal brightness is 25% greater than the polar brightness.The National Center for Atmospheric Research is sponsored by the National Science Foundation.  相似文献   

Pioneer 10 ultraviolet photometer observations of the Jovian hydrogen torus: The angular distribution     

R.W. Carlson  D.L. Judge 《Icarus》1975,24(4):395-399

The Pioneer 10 ultraviolet photometer observations of the Jovian hydrogen torus are analyzed to obtain the angular distribution. The cloud is asymmetric about Io, where the atoms presumably originate, with the greater density occurring in the trailing portion. A simple model which assumes Jeans escape from the atmosphere of Io is developed and compared to the observations. The results suggest that the exospheric temperature is high (～3000 K) and that the ionization lifetime of the cloud atoms is ～1 × 10⁵ sec.  相似文献   

S-wave velocity structure, mantle xenoliths and the upper mantle beneath the Kaapvaal craton   总被引：1，自引：0，他引：1  

Angela Marie Larson  J. Arthur Snoke  David E. James 《Geophysical Journal International》2006,167(1):171-186

  相似文献   

A subduction wedge origin for Paleoarchean peridotitic diamonds and harzburgites from the Panda kimberlite, Slave craton: evidence from Re–Os isotope systematics     

K. J. Westerlund  S. B. Shirey  S. H. Richardson  R. W. Carlson  J. J. Gurney  J. W. Harris 《Contributions to Mineralogy and Petrology》2006,152(3):275-294

An extensive study of peridotitic sulfide inclusion bearing diamonds and their prospective harzburgitic host rocks from the 53 Ma Panda kimberlite pipe, Ekati Mine, NWT Canada, has been undertaken with the Re–Os system to establish their age and petrogenesis. Diamonds with peridotitic sulfide inclusions have poorly aggregated nitrogen (<30% N as B centers) at N contents of 200–800 ppm which differs from that of chromite and silicate bearing diamonds and indicates residence in the cooler portion of the Slave craton lithospheric mantle. For most of the sulfide inclusions, relatively low Re contents (average 0.457 ppm) and high Os contents (average 339 ppm) lead to extremely low ¹⁸⁷Re/¹⁸⁸Os, typically << 0.05. An age of 3.52 ± 0.17 Ga (MSWD = 0.46) and a precise initial ¹⁸⁷Os/¹⁸⁸Os of 0.1093 ± 0.0001 are given by a single regression of 11 inclusions from five diamonds that individually provide coincident internal isochrons. This initial Os isotopic composition is 6% enriched in ¹⁸⁷Os over 3.5 Ga chondritic or primitive mantle. Sulfide inclusions with less radiogenic initial Os isotopic compositions reflect isotopic heterogeneity in diamond forming fluids. The harzburgites have even lower initial ¹⁸⁷Os/¹⁸⁸Os than the sulfide inclusions, some approaching the isotopic composition of 3.5 Ga chondritic mantle. In several cases isotopically distinct sulfides occur in different growth zones of the same diamond. This supports a model where C–O–H–S fluids carrying a radiogenic Os signature were introduced into depleted harzburgite and produced diamonds containing sulfides conforming to the 3.5 Ga isochron. Reaction of this fluid with harzburgite led to diamonds with less radiogenic inclusions while elevating the Os isotope ratios of some harzburgites. Subduction is a viable way of introducing such fluids. This implies a role for subduction in creating early continental nuclei at 3.5 Ga and generating peridotitic diamonds.Electronic Supplementary Material Supplementary material is available for this article at and is accessible for authorized users.  相似文献   

Teaching about relict, no-analog landscapes     

Arthur L. Bloom   《Geomorphology》2002,47(2-4)

Only a few very young landforms are the result of currently operating geomorphic processes. Because the time scale for landscape evolution is much longer than the time scale for late Cenozoic climate changes, almost all landscapes are palimpsests, written over repeatedly by various combinations of climate-determined processes. Relict glacial and periglacial landforms are widely identified in mid-latitude regions that have been traditionally described as having been shaped by the “normal” processes of fluvial erosion. Less confidently, deeply weathered regolith and associated relict landforms in the middle and high latitudes are attributed to early Tertiary warmth. However, assemblages of geomorphic processes specific to certain climatic regions, like faunal and floral assemblages, cannot be translated across latitude, so in spite of the many books about the geomorphology of specific modern climate regions, there are few sources that discuss former warm high-latitude, or cold low-latitude, low-altitude geomorphic processes that have no modern analogs. Students and teachers alike who attempt to interpret landforms by extrapolating modern climatic conditions to other latitudinal zones will find their outlook broadened, and they become better prepared to consider the geomorphic impacts of global climate change.  相似文献