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41.
We report trace element analyses by laser ablation inductively coupled plasma mass spectrometry (LA‐ICP‐MS) of metal grains from nine different CR chondrites, distinguishing grains from chondrule interior (“interior grains”), chondrule surficial shells (“margin grains”), and the matrix (“isolated grains”). Save for a few anomalous grains, Ni‐normalized trace element patterns are similar for all three petrographic settings, with largely unfractionated refractory siderophile elements and depleted volatile Au, Cu, Ag, S. All three types of grains are interpreted to derive from a common precursor approximated by the least‐melted, fine‐grained objects in CR chondrites. This also excludes recondensation of metal vapor as the origin of the bulk of margin grains. The metal precursors were presumably formed by incomplete condensation, with evidence for high‐temperature isolation of refractory platinum‐group‐element (PGE)‐rich condensates before mixing with lower temperature PGE‐depleted condensates. The rounded shape of the Ni‐rich, interior grains shows that they were molten and that they equilibrated with silicates upon slow cooling (1–100 K h?1), largely by oxidation/evaporation of Fe, hence their high Pd content, for example. We propose that Ni‐poorer, amoeboid margin grains, often included in the pyroxene‐rich periphery common to type I chondrules, result from less intense processing of a rim accreted onto the chondrule subsequent to the melting event recorded by the interior grains. This means either that there were two separate heating events, which formed olivine/interior grains and pyroxene/margin grains, respectively, between which dust was accreted around the chondrule, or that there was a single high‐temperature event, of which the chondrule margin records a late “quenching phase,” in which case dust accreted onto chondrules while they were molten. In the latter case, high dust concentrations in the chondrule‐forming region (at least three orders of magnitude above minimum mass solar nebula models) are indicated.  相似文献   
42.
Multi-drug resistance (MDR) in MCF7 breast cancer cells and multi-xenobiotic resistance (MXR) in mussel (Mytilus edulis) blood cells (MBC) are well known mechanisms that contribute to the decrease in intracellular concentrations of many unrelated but cytotoxic compounds. In the present work, we have carried out comparative investigations of the MDR/MXR protective mechanisms using a rapid colorimetric assay for cell viability and calcein accumulation for MDR/MXR activities. These studies were performed using cultured MCF7 and MBC before and after in vitro exposure to xenobiotics. Our results indicate that a 5-day exposure to doxorubicin or vincristine decreased calcein accumulation in MBC which is consistent with an induction of multi-xenobiotic resistance. The increase in calcein accumulation provoked by 1-h treatment with 50 microM verapamil was much lower in MBC when compared to the P-glycoprotein overexpressing MCF7 cell line. We conclude that such microplate assays could be used in primary cultures of MBC to estimate the effects of various chemicals on MXR activity.  相似文献   
43.
Wauters  L.  Dominique  M.  Milligan  R.  Dammasch  I. E.  Kretzschmar  M.  Machol  J. 《Solar physics》2022,297(3):1-22

In most of the solar cycles, activity in the northern and southern hemispheres peaks at different times. One hemisphere peaks well before the other, and at least one of the hemispheric maxima frequently does not coincide with the whole sphere maximum. Prediction of the maximum of a hemisphere and the corresponding north–south asymmetry of a solar cycle may help to understand the mechanisms of the solar cycle, the solar-terrestrial relationship, and solar-activity influences on space weather. Here we analysed the sunspot-group data from the Greenwich Photoheliographic Results (GPR) during 1874?–?1976 and Debrecen Photoheliographic Data (DPD) during 1977?–?2017 and studied the cycle-to-cycle variations in the values of 13-month smoothed monthly mean sunspot-group area in the whole sphere (WSGA), northern hemisphere (NSGA), and southern hemisphere (SSGA) at the epochs of maxima of Sunspot Cycles 12?–?24 and at the epochs of maxima of WSGA, NSGA, and SSGA Cycles 12?–?24 (note that solar-cycle variation of a parameter is expressed as a cycle of that parameter). The cosine fits to the values of WSGA, NSGA, and SSGA at the maxima of sunspot, WSGA, NSGA, and SSGA Cycles 12?–?24, and to the values of the corresponding north–south asymmetry, suggest the existence of a ≈132-year periodicity in the activity of the northern hemisphere, a 54?–?66-year periodicity in the activity of the southern hemisphere, and a 50?–?66 year periodicity in the north–south asymmetry in activity at all the aforementioned epochs. By extrapolating the best-fit cosine curves we predicted the amplitudes and the corresponding north–south asymmetry of the 25th WSGA, NSGA, and SSGA cycles. We find that on average Solar Cycle 25 in sunspot-group area would be to some extent smaller than Solar Cycle 24 in sunspot-group area. However, by inputting the predicted amplitudes of the 25th WSGA, NSGA, and SSGA cycles relationship between sunspot-group area and sunspot number we find that the amplitude (\(130\pm 12\)) of Sunspot Cycle 25 would be slightly larger than that of reasonably small Sunspot Cycle 24. Still it confirms that the beginning of the upcoming Gleissberg cycle would take place around Solar Cycle 25. We also find that except at the maximum of NSGA Cycle 25 where the strength of activity in the northern hemisphere would be dominant, the strength of activity in the southern hemisphere would be dominant at the maximum epochs of the 25th sunspot, WSGA, and SSGA cycles.

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44.
Bwambale  Bosco  Nyeko  Martine  Sekajugo  John  Kervyn  Matthieu 《Natural Hazards》2022,110(3):1847-1867
Natural Hazards - The integration of indigenous knowledge into understanding disasters from natural hazards is hitherto hampered by the limited conceptualization of the process that shapes...  相似文献   
45.
The famous Rhaetian bone bed (Late Triassic, 205 Ma) is well known because it marks a major switch in depositional environment from terrestrial red beds to fully marine conditions throughout the UK and much of Europe. The bone bed is generally cemented and less than 10 cm thick. However, we report here an unusual case from Saltford, near Bath, S.W. England where the bone bed is unconsolidated and up to nearly 1 m thick. The exposure of the basal beds of the Westbury Formation, Penarth Group includes a bone bed containing a diverse Rhaetian marine microvertebrate fauna dominated by sharks, actinopterygian fishes and reptiles. Despite the unusual sedimentary character of the bone bed, we find similar proportions of taxa as in other basal Rhaetian bone beds (55–59 % Lissodus teeth, 13–16 % Rhomphaiodon teeth, 12–14 % Severnichthys teeth, 6–9% Gyrolepis teeth, 3–4% undetermined sharks’ teeth, 1–3% undetermined bony fish teeth, and < 1% of each of Hybodus, Parascylloides, and Sargodon), the only differences being in the proportions of Rhomphaiodon teeth, which can represent 30–40 % of specimens elsewhere. This suggests that taphonomic bias of varying Rhaetian bone beds may be comparable despite different sedimentary settings, and that the proportions of taxa say something about their original proportions in the ecosystem.  相似文献   
46.
Dengue fever is the most prevalent mosquito-borne viral disease of humans in tropical lands. As an efficient vaccine is not yet available, the only means to prevent epidemics is to control mosquito populations. These are influenced by human behavior and climatic conditions and thus, need constant effort and are very expansive. Examples of succeeded prevention are rare because of the continuous reintroduction of virus or vector from outside, or growing resistance of mosquito populations to insecticides. Climate variability and global warming are other factors which may favour epidemics of dengue. During a pilot study in Claris EC project, a model for the transmission of dengue was built, to serve as a tool for estimating the risk of epidemic transmission and eventually forecasting the risk under climatic change scenarios. An ultimate objective would be to use the model as an early warning system with meteorological forecasts as input, thus allowing better decision making and prevention.  相似文献   
47.
48.
A detailed rock magnetic investigation of loess/palaeosol samples from the section at Lingtai on the central Chinese Loess Plateau (CLP) is presented. Thermal demagnetisation of isothermal remanent magnetisation (IRM) and Curie temperature measurements suggest the presence of magnetite, maghemite and hematite as remanence carrying components. Bulk and grain size fractionated samples have been analysed using coercivity spectra of remanence acquisition/demagnetisation curves, which identify four main remanence carriers in different grain size fractions of loesses and palaeosols. A linear source mixing model quantifies the contribution of the four components which have been experimentally derived as dominating endmembers in specific grain size fractions. Up to two thirds of the total IRM of the palaeosols are due to slightly oxidised pedogenic magnetite. Two detrital components dominate up to 90% of the IRM of the loess samples and are ascribed to maghemite of different oxidation degree. Detrital hematite is present in all samples and contributes up to 10% of the IRM. The iron content of the grain size fractions gives evidence that iron in pedogenically grown remanence carriers does not originate from the detrital iron oxides, but rather from iron-bearing clays and mafic silicates. The contribution of pedogenic magnetite to the bulk IRM increases with the increasing degree of pedogenesis, which depends in turn on climate change.  相似文献   
49.
Peruvian anchovy (Engraulis ringens) stock abundance is tightly driven by the high and unpredictable variability of the Humboldt Current Ecosystem. Management of the fishery therefore cannot rely on mid- or long-term management policy alone but needs to be adaptive at relatively short time scales. Regular acoustic surveys are performed on the stock at intervals of 2 to 4 times a year, but there is a need for more time continuous monitoring indicators to ensure that management can respond at suitable time scales. Existing literature suggests that spatially explicit data on the location of fishing activities could be used as a proxy for target stock distribution. Spatially explicit commercial fishing data could therefore guide adaptive management decisions at shorter time scales than is possible through scientific stock surveys. In this study we therefore aim to (1) estimate the position of fishing operations for the entire fleet of Peruvian anchovy purse–seiners using the Peruvian satellite vessel monitoring system (VMS), and (2) quantify the extent to which the distribution of purse–seine sets describes anchovy distribution. To estimate fishing set positions from vessel tracks derived from VMS data we developed a methodology based on artificial neural networks (ANN) trained on a sample of fishing trips with known fishing set positions (exact fishing positions are known for approximately 1.5% of the fleet from an at-sea observer program). The ANN correctly identified 83% of the real fishing sets and largely outperformed comparative linear models. This network is then used to forecast fishing operations for those trips where no observers were onboard. To quantify the extent to which fishing set distribution was correlated to stock distribution we compared three metrics describing features of the distributions (the mean distance to the coast, the total area of distribution, and a clustering index) for concomitant acoustic survey observations and fishing set positions identified from VMS. For two of these metrics (mean distance to the coast and clustering index), fishing and survey data were significantly correlated. We conclude that the location of purse–seine fishing sets yields significant and valuable information on the distribution of the Peruvian anchovy stock and ultimately on its vulnerability to the fishery. For example, a high concentration of sets in the near coastal zone could potentially be used as a warning signal of high levels of stock vulnerability and trigger appropriate management measures aimed at reducing fishing effort.  相似文献   
50.
The present paper focuses on the governing equations for the sensitivity of the variables to the parameters in flow models that can be described by one-dimensional scalar, hyperbolic conservation laws. The sensitivity is shown to obey a hyperbolic, scalar conservation law. The sensitivity is a conserved scalar except in the case of discontinuous flow solutions, where an extra, point source term must be added to the equations in order to enforce conservation. The propagation speed of the sensitivity waves being identical to that of the conserved variable in the original conservation law, the system of conservation laws formed by the original hyperbolic equation and the equation satisfied by the sensitivity is linearly degenerate. A consequence on the solution of the Riemann problem is that rarefaction waves for the variable of the original equation result in vacuum regions for the sensitivity. The numerical solution of the hyperbolic conservation law for the sensitivity by finite volume methods requires the implementation of a specific shock detection procedure. A set of necessary conditions is defined for the discretisation of the source term in the sensitivity equation. An application to the one-dimensional kinematic wave equation shows that the proposed numerical technique allows analytical solutions to be reproduced correctly. The computational examples show that first-order numerical schemes do not yield satisfactory numerical solutions in the neighbourhood of moving shocks and that higher-order schemes, such as the MUSCL scheme, should be used for sharp transients.  相似文献   
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