Differential developmental toxicity of naphthoic acid isomers in medaka (Oryzias latipes) embryos     

Carney MW  Erwin K  Hardman R  Yuen B  Volz DC  Hinton DE  Kullman SW 《Marine pollution bulletin》2008,57(6-12):255-266

Polycyclic aromatic hydrocarbons (PAHs) are widespread persistent pollutants that readily undergo biotic and abiotic conversion to numerous transformation products in rivers, lakes and estuarine sediments. Here we characterize the developmental toxicity of four PAH transformation products each structural isomers of hydroxynaphthoic acid: 1H2NA, 2H1NA, 2H3NA, and 6H2NA. Medaka fish (Oryzias latipes) embryos and eleutheroembryos were used to determine toxicity. A 96-well micro-plate format was used to establish a robust, statistically significant platform for assessment of early life stages. Individual naphthoic acid isomers demonstrated a rank order of toxicity with 1H2NA>2H1NA>2H3NA>6H2NA being more toxic. Abnormalities of circulatory system were most pronounced including pericardial edema and tube heart. To determine if HNA isomers were AhR ligands, spatial-temporal expression and activity of CYP1A was measured via in vivo EROD assessments. qPCR measurement of CYP1A induction proved different between isomers dosed at respective concentrations affecting 50% of exposed individuals (EC50s). In vitro, all ANH isomers transactivated mouse AhR using a medaka CYP1A promoter specific reporter assay. Circulatory abnormalities followed P450 induction and response was consistent with PAH toxicity. A 96-well micro-plates proved suitable as exposure chambers and provided statistically sound evaluations as well as efficient toxicity screens. Our results demonstrate the use of medaka embryos for toxicity analysis thereby achieving REACH objectives for the reduction of adult animal testing in toxicity evaluations.  相似文献   

Dynamics of rotationally fissioned asteroids: Source of observed small asteroid systems     

Seth A. Jacobson  Daniel J. Scheeres 《Icarus》2011,214(1):161-178

We present a model of near-Earth asteroid (NEA) rotational fission and ensuing dynamics that describes the creation of synchronous binaries and all other observed NEA systems including: doubly synchronous binaries, high-e binaries, ternary systems, and contact binaries. Our model only presupposes the Yarkovsky-O’Keefe-Radzievskii-Paddack (YORP) effect, “rubble pile” asteroid geophysics, and gravitational interactions. The YORP effect torques a “rubble pile” asteroid until the asteroid reaches its fission spin limit and the components enter orbit about each other (Scheeres, D.J. [2007]. Icarus 189, 370-385). Non-spherical gravitational potentials couple the spin states to the orbit state and chaotically drive the system towards the observed asteroid classes along two evolutionary tracks primarily distinguished by mass ratio. Related to this is a new binary process termed secondary fission - the secondary asteroid of the binary system is rotationally accelerated via gravitational torques until it fissions, thus creating a chaotic ternary system. The initially chaotic binary can be stabilized to create a synchronous binary by components of the fissioned secondary asteroid impacting the primary asteroid, solar gravitational perturbations, and mutual body tides. These results emphasize the importance of the initial component size distribution and configuration within the parent asteroid. NEAs may go through multiple binary cycles and many YORP-induced rotational fissions during their approximately 10 Myr lifetime in the inner Solar System. Rotational fission and the ensuing dynamics are responsible for all NEA systems including the most commonly observed synchronous binaries.  相似文献   

A New Algorithm for Continuous Area Cartogram Construction with Triangulation of Regions and Restriction on Bearing Changes of Edges     

Seth E. Spielman 《制图学和地理信息科学》2013,40(2):115-124

Collective intelligence is the idea that under the right circumstances collections of individuals are smarter than even the smartest individuals in the group, that is a group has an “intelligence” that is independent of the intelligence of its members. The ideology of collective intelligence undergirds much of the enthusiasm about the use of “volunteered” or crowd-sourced geographic information. Literature from a variety of fields makes clear that not all groups possess collective intelligence, this article identifies four pre-conditions for the emergence of collective intelligence and then examines the extent to which collectively generated mapping systems satisfy these conditions. However, the “intelligence” collectively generated maps is hard to assess because there are two difficult to reconcile perspectives on map quality – the credibility perspective and the accuracy perspective. Much of the current literature on user-generated maps focuses on assessing the quality of individual contributions. However, because user-generated maps are complex social systems and because the quality of a contribution is difficult to assess this strategy may not yield an “intelligent” end product. The existing literature on collective intelligence suggests that the structure of groups is more important than the intelligence of group members. Applying this idea to user-generated maps suggests that systems should be designed to foster conditions known to produce collective intelligence rather than privileging particular contributions/contributors. The article concludes with some design recommendations and by considering the implications of collectively generated maps for both expert knowledge and traditional state sponsored mapping programs.  相似文献   

Failed magmatic eruptions: late-stage cessation of magma ascent   总被引：4，自引：2，他引：2  

Seth C. Moran  Chris Newhall  Diana C. Roman 《Bulletin of Volcanology》2011,73(2):115-122

When a volcano becomes restless, a primary question is whether the unrest will lead to an eruption. Here we recognize four possible outcomes of a magmatic intrusion: “deep intrusion”, “shallow intrusion”, “sluggish/viscous magmatic eruption”, and “rapid, often explosive magmatic eruption”. We define “failed eruptions” as instances in which magma reaches but does not pass the “shallow intrusion” stage, i.e., when magma gets close to, but does not reach, the surface. Competing factors act to promote or hinder the eventual eruption of a magma intrusion. Fresh intrusion from depth, high magma gas content, rapid ascent rates that leave little time for enroute degassing, opening of pathways, and sudden decompression near the surface all act to promote eruption, whereas decreased magma supply from depth, slow ascent, significant enroute degassing and associated increases in viscosity, and impingement on structural barriers all act to hinder eruption. All of these factors interact in complex ways with variable results, but often cause magma to stall at some depth before reaching the surface. Although certain precursory phenomena, such as rapidly escalating seismic swarms or rates of degassing or deformation, are good indicators that an eruption is likely, such phenomena have also been observed in association with intrusions that have ultimately failed to erupt. A perpetual difficulty with quantifying the probability of eruption is a lack of data, particularly on instances of failed eruptions. This difficulty is being addressed in part through the WOVOdat database. Papers in this volume will be an additional resource for scientists grappling with the issue of whether or not an episode of unrest will lead to a magmatic eruption.  相似文献   

Model of photoelectron impact ionization within the high latitude ionosphere at Mars: Comparison of calculated and measured electron density     

S.A. Haider  S.P. Seth  V.R. Choksi 《Icarus》2006,185(1):102-112

The production rate, ion density and electron density are calculated between longitudes 0° and 360° E due to incident radiation of wavelength range 1-102.57 nm in the dayside atmosphere of Mars. These calculations are made by using global analytical yield spectrum (AYS) model at solar zenith angle 80° between latitudes 50° and 70° N for spring equinox and medium solar activity condition. These conditions are appropriate for Mars Global Surveyor (MGS) Phase 2 aerobraking period during which both the accelerometer and the radio occultation data are used. The calculated results are compared with MGS radio occultation measurements carried out at different latitudes (64.7°-67.3° N) and longitudes (0°-360° E) in December 1998 between solar zenith angle 78° and 81°. This measurement shows primary and secondary ionization peaks, which are varying with longitudes. Our calculation suggests that first peak is produced by photoionization and photoelectron impact ionization processes due to absorption of solar EUV radiation (9-102.57 nm). The second peak is produced by photoelectron impact ionization of soft X-ray photon (1-9 nm). There is a good agreement between our calculation and measurement as far as the maximum and the minimum values of primary peak altitude/peak density of electrons are concerned. However, the calculated values of secondary peak density and peak altitude are higher than the measured values by a factor of 1.5-2.0 and 1.1, respectively. The secondary peak is brought into agreement with the measurement using low X-ray flux by a factor of 2 to 3 below 9 nm. The longitudinal distribution of calculated and measured peak density and peak altitude are fitted by least-square method with 0.95 confidence limits.  相似文献   

Time-dependent solution for a one-dimensional piston problem in a non-ideal gas     

Sharad Chandra Purohit 《Astrophysics and Space Science》1980,70(1):239-242

In this article we study the effect of a non-ideal gas parameter on the piston (contact) surface when a strong shock moves into a non-uniform medium. The solution corresponding to the ideal gas can be obtained as a particular case of the analysis.  相似文献   

Tritium in ground water of the georgia piedmont: Implications for recharge and flow paths     

Seth Rose 《水文研究》1992,6(1):67-78

Environmental tritium was measured in 33 natural water samples representative of precipitation, stream runoff, and groundwater (derived principally from production wells) within the Georgia Piedmont Province. Major ion analyses were used to assist in the interpretation of the tritium results. Tritium concentrations were significantly greater within shallow groundwater derived from the regolith (28–34 TU) and stream runoff (25–30 TU) than within recent rainfall (4–17 TU). Based upon the decay-corrected tritium input function, this probably indicates that at least some of the shallow water is stored within the regolith for a period of approximately 25 years. A ‘post-bomb’ component of recharge was present in all groundwater derived from production wells in the study area. Groundwater sampled from the bedrock aquifers was commonly less tritiated than either stream runoff or shallow water stored in the regolith. the lower tritium concentrations May, have resulted from the mixing of ‘pre-bomb’ water stored within the fractures or the transitional zone directly above the bedrock and modern water stored in the shallow regolith. the preponderance of modern water provides evidence that groundwater flow paths are areally restricted within this setting, probably confined to local surface water drainage basins. the residence time of groundwater in the Piedmont is limited by the lack of deep, gravity-driven regional flow and the localized vertical flow induced by pumping. the results of this study indicate that relatively small tritium concentration variations (10-20 TU) May, have regional hydrological significance in the southeastern Piedmont Province and similar settings.  相似文献   

Use of a bubble tiltmeter as a horizontal seismometer     

Wayne F. Miller  Robert J. Geller  Seth Stein 《Geophysical Journal International》1978,54(3):661-668

Summary. A bubble tiltmeter has been used as a horizontal seismometer. With the appropriate filters, the bubble system has good response for displacement over the passband of conventional seismometers (from about 10 Hz to 200 s), and for tilt from about 1 Hz to DC. The accuracy of the response is confirmed by comparing the filtered bubble output to conventional seismic instruments. The agreement between the filtered bubble records and broad band ( T ₀= 1 s, T _g= 90 s) and short period ( T ₀= 1 s, T_g= 0.2 s) conventional records is extremely good in every case.
The small size, broad-band response, and lack of moving parts make the bubble ideal as an instrument for remote environments. In particular, the instrument seems ideal for the ocean bottom, land and marine boreholes and planetary missions.  相似文献   

A statistical methodology for assessing the long‐term effects of antecedent drought conditions on stream runoff: applications to the Piedmont Province,southeastern United States     

Seth Rose 《水文研究》2011,25(6):901-914

A method was developed to investigate the long‐term (months‐to‐years) effects (both magnitude and duration) of antecedent rainfall upon subsequent runoff coefficients (RCs) or runoff/rainfall ratios. The method was applied to a four‐state region (Georgia, South Carolina, North Carolina, and Virginia) within the southeastern Piedmont Province of the United States and incorporated a 59‐year data set of 19 United States Geological Survey stream gages and 57 National Climatic Data Center rain gages. The method was designed to facilitate statistical comparisons [Mann–Whitney rank sum tests] between various groups of normalized runoff coefficients (NRCs) representing 6–36 month periods which differed in terms of antecedent rainfall conditions. The results of this study show that under all subsequent rainfall conditions, with the exception of excess rainfall, a 1‐year period of antecedent drought lowered NRCs for at least 1 year following the drought. The principal finding of this study is that a year‐long drought period within the southeastern Piedmont Province lowers NRCs by ～25% during the following year when rainfall returns to normal. In most cases, RCs are significantly lower during the second year following a drought than they would be when anteceded by normal rainfall; however, the effects of drought wane during this period. This is a statistical and regional method that can be modified to other study areas; however, it cannot be used to predict storm‐event rainfall–runoff relationships for any specific basin. Copyright © 2010 John Wiley & Sons, Ltd.  相似文献   

Geochemical variations in the Cocos Plate subducting beneath Central America: implications for the composition of arc volcanism and the extent of the Galápagos Hotspot influence on the Cocos oceanic crust     

Seth Sadofsky  Kaj Hoernle  Svend Duggen  Folkmar Hauff  Reinhard Werner  Dieter Garbe-Schönberg 《International Journal of Earth Sciences》2009,98(4):901-913

New geochemical data from the Cocos Plate constrain the composition of the input into the Central American subduction zone and demonstrate the extent of influence of the Galápagos Hotspot on the Cocos Plate. Samples include sediments and basalts from Ocean Drilling Program (ODP) Site 1256 outboard of Nicaragua, gabbroic sills from ODP Sites 1039 and 1040, tholeiitic glasses from the Fisher Ridge off northwest Costa Rica, and basalts from the Galápagos Hotspot Track outboard of Central Costa Rica. Site 1256 basalts range from normal to enriched MORB in incompatible elements and have Pb and Nd isotopic compositions within the East Pacific Rise MORB field. The sediments have similar ²⁰⁶Pb/²⁰⁴Pb and only slightly more radiogenic ²⁰⁷Pb/²⁰⁴Pb and ²⁰⁸Pb/²⁰⁴Pb isotope ratios than the basalts. Altered samples from the subducting Galápagos Hotspot Track have similar Nd and Pb isotopic compositions to fresh Galápagos samples but have significantly higher Sr isotopic composition, indicating that the subduction input will have a distinct geochemical signature from Galápagos-type mantle material that may be present in the wedge beneath Costa Rica. Gabbroic sills from Sites 1039 and 1040 in East Pacific Rise (EPR) crust show evidence for influence of the Galápagos Hotspot ∼100 km beyond the morphological hotspot track.  相似文献