基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制          下载免费PDF全文

王家辉  王军文  彭湘宁 《应用海洋学学报》2024,40(2):189

目的：基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制。方法：应用TCMSP和UniProt数据库平台查询青蛇方组方的有效活性成分及靶基因,与疾病靶基因取交集后构建蛋白质-蛋白质相互作用(PPI)网络;应用DAVID数据库,对潜在核心作用靶点基因进行基因本体（GO）功能、京都基因与基因组百科全书（KEGG）通路富集分析。利用分子对接原理论证青蛇方生物活性成分与核心靶点的分子结合能力。结果：筛选出青蛇方有效成分63种,作用靶点99个;主要有β-谷甾醇、2,4,7-三羟基-9,10-二氢菲、靛蓝素、豆甾醇、色氨酸等关键成分;转录因子AP-1（JUN）、肿瘤坏死因子（TNF）、原癌基因（RELA）、干扰素γ（IFNG）、转化生长因子-β1（TGF-β1）等核心基因。关键信号通路有癌症信号通路、恰加斯病通路、弓形体病通路、脂质和动脉粥样硬化通路等,分子对接结果显示活性成分与核心靶点基因结合能力较强。结论：青蛇方外用可以通过多种活性成分、多种通路有效抑制免疫炎症反应,促进免疫系统正常运行,从而达到治疗湿疹的目的。  相似文献   

On the spatial characteristic of the short term and imminent anomalies of underground water behaviors before strong earthquake     

杜学彬  刘耀炜  倪明康 《地震学报(英文版)》1997,10(4):523-533

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Sector collapse,sedimentation and clast population evolution at an active island-arc volcano: Stromboli,Italy   总被引：1，自引：0，他引：1  

P. Kokelaar  C. Romagnoli 《Bulletin of Volcanology》1995,57(4):240-262

Sciara del Fuoco is the subaerial part of a partially filled sector-collapse scar that extends to 700 m below sea level on Stromboli volcano. The collapse occurred <5000 years ago, involved 1.81 km³ of rock and is the latest of a series of major collapses on the north-west flank of Stromboli. A north-east trending arc-axial fault system channels magmas into the volcano and has caused tilting and/or downthrow to the north-west. The slope of the partial cone constructed between the lateral walls of the collapse scar acts as a channelway to the sea for most eruptive products. From 700 m below sea level and extending to >2200 m and >10 km from the shore to the NNW, a fan-shaped mounded feature comprises debris avalanche deposits (>4 km³) from two or more sector collapses. Volcaniclastic density currents originating from Sciara del Fuoco follow the topographic margin of the debris avalanche deposits, although overbank currents and other unconfined currents widely cover the mounded feature with turbidites. Historical (recorded) eruptive activity in Sciara del Fuoco is considerably less than that which occurred earlier, and much of the partial fill may have formed from eruptions soon after the sector collapse. It is possible that a mass of eruptive products similar to that in the collapse scar is dispersed as volcanogenic sediment in deep water of the Tyrhennian basin. Evidence that the early post-collapse eruptive discharge was greater than the apparent recent flux (2kg/s) counters suggestions that a substantial part of Stromboli's growth has been endogenous. The partial fill of Sciaria del Fuoco is dominated by lava and spatter layers, rather than by the scoria and ash layers classically regarded as main constituents of Strombolian (cinder) cones. Much of the volcanic slope beneath the vents is steeper than the angle of repose of loose tephra, which is therefore rapidly transported to the sea. Delicate pyroclasts that record the magmatic explosivity are selectively destroyed and diluted during sedimentary transport, mainly in avalanches and by shoreline wave reworking, and thus the submarine deposits do not record well the extent and diversity of explosive activity and associated clast-forming processes. Considerable amounts of dense (non-vesicular) fine sand and silt grains are produced by breakage and rounding of fragments of lava and agglutinate. The submarine extension of the collapse scar, and the continuing topographic depression to >2200 m below sea level, are zones of considerable by-passing of fine sand and silt, which are transported in turbidity currents. Evidently, volcanogenic sediments dispersed around island volcanoes by density currents are unlikely to record well the true spectrum and relative importance of clast-forming processes that occurred during an eruption. Marine sedimentary evidence of magmatic explosivity is particularly susceptible to partial or complete obliteration, unless there is a high rate of discharge of pyroclastic material into the sea.  相似文献   

A continuous and mechanistic representation of calcite reaction-controlled kinetics in dilute solutions at 25°C and 1 atm total pressure     

Takeshi Arakaki  Alfonso Mucci 《Aquatic Geochemistry》1995,1(1):105-130

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洛安江干渠老菁湾滑坡分析     

周华志 《工程地质学报》1995,3(1):86-91

洛安江水库灌溉工程是贵州黔北万亩以上骨干工程之一,中华人民共和国成立初期建成。１９９１年＂７．５Ｆ＂洪灾,连续大暴雨,河水暴涨,倒灌暗河,产生高静、动水压力作用。岸坡岩体受不利结构面组合,发生顺层岩质滑坡,破坏干渠,严重影响灌溉。本文根据滑坡破坏情况,对滑坡产生的地质环境、滑坡特征、滑坡形成机理（滑坡形式和破坏机理,各种稳定性分析与评价）,以及产生滑坡原因进行了初步分析。  相似文献   

A combined study of macroseismic data and focal mechanisms applied to the West-Bohemian earthquake,Czechoslovakia     

J. Zahradník  M. Antonini  G. Grünthal  J. Janský  D. Procházková  E. Schmedes  A. Špičak  J. Zedník 《Pure and Applied Geophysics》1990,133(1):53-71

The main shock of the West-Bohemian earthquake swarm, Czechoslovakia, (magnitudem=4.5, depthh=10 km) exhibits an irregular areal distribution of macroseismic intensities 6° to 7° MSK-64. Four lobes of the 6° isoseismal are found and the maximum observed intensity is located at a distance of 8 km from the instrumentally determined epicentre. This distribution can be explained by the energy flux of the directS wave generated by a circular source, the hypocentral location and focal mechanism of which are taken from independent instrumental studies. The theoretical intensity, which is assumed to be logarithmically proportional to the integrated squared ground-motion velocity (i.e.,I=const+log v ² (t)dt), fits the observed intensity with an overall root-mean-square error less than 0.5°. It is important that the present intensity data can also be equally well explained by the isotropic source. The fit was attained by means of a horizontally layered model though large fault zones and an extended sedimentary basin suggest a significant lateral heterogeneity of the epicentral region. The results encourage a broader application of the simple modelling technique used.  相似文献   

隐性旅游资源显性化机理的现象学解读     

黄英  翟辅东  龙良富 《云南地理环境研究》2006,18(4):46-49

在隐性与显性旅游资源二元应用性分类框架的设想下，《隐性旅游资源显性化机理的现象学解读》一文通过演绎推理、实证研究等方法，第一次运用现象学（解释学）的本质直觉学说、非实显性变样理论、“交流理性”理论等对隐性旅游资源显性化机理进行了全新解读。它提出了洞悉隐性旅游资源本质的一条基本原则——身临其境的切身体验；认为隐性旅游资源是人的体验流中的一种相对性存在形态，是旅游吸引物的非实显性组成部分；为隐性旅游资源显性化构建出价值观动力、形象思维动力和平民化意识动力；最后通过对游客体验“真实性”问题的现象学阐述，为隐性旅游资源显性化即具有吸引力，寻找到动力源泉。  相似文献   

Treatment of high fluoride concentration wastewater by layered double hydroxides： Mechanism studies   总被引：1，自引：0，他引：1  

Liang LU Jing HE 《中国地球化学学报》2006,25(B08):160-161

An appropriate concentration of fluoride in drinking water is required to prevent dental cavities, but long-term ingestion of water that contains more than a suitable level of fluoride can cause bone disease and mottling of the teeth. Fluoride ions can be found in wastewater from the fluoride chemical industry, as well as the semiconductor, metal processing, fertilizer, and glass-manufacturing industries. The discharge standard for fluoride in industrial wastewater in China is 10 mg/L. Efficient treatment of fluoride-containing wastewater is therefore of major concern in China, following the rapid development of the fluoride chemical industry. Several methods have been used to remove fluoride from water, such as adsorption, chemical precipitation, electrodialysis, ion exchange and electrochemical processes. Layered double hydroxides （LDHs） are anionic clays with high anion exchange capacities which are effective adsorbents for removal of a variety of anionic pollutants. LDHs have been studied as potential adsorbents for removing toxic anionic species such as CrO4^2-, TcO4^-, SeO3^2-, pesticides, and anionic surfactants from aqueous systems. One of the main attractions of using LDHs for fluoride removal, is that unlike other chemical treatment methods, no chemical sludge should be produced. In the present study, an attempt was made to investigate the mechanism of fluoride removal by LDHs under different conditions using batch methods. In addition, the release of fluoride adsorbed on LDHs by treatment with an aqueous solution of Na2CO3 was studied. The residual fluoride was found to be 10 mg/L in a solution with an initial concentration of 1000 mg/L, which meets the discharge standard for fluoride in industrial wastewater in China.  相似文献   

Porphyroblast rotation during crenulation cleavage development: an example from the aureole of the Mooselookmeguntic pluton, Maine, USA   总被引：1，自引：0，他引：1  

S. E. JOHNSON  M. E. DUPEE  C. V. GUIDOTTI 《Journal of Metamorphic Geology》2006,24(1):55-73

In the low‐pressure, high‐temperature metamorphic rocks of western Maine, USA, staurolite porphyroblasts grew at c. 400 Ma, very late during the regional orogenesis. These porphyroblasts, which preserve straight inclusion trails with small thin‐section‐scale variation in pitch, were subsequently involved in the strain and metamorphic aureole of the c. 370 Ma Mooselookmeguntic pluton. The aureole shows a progressive fabric intensity gradient from effectively zero emplacement‐related deformation at the outer edge of the aureole ～2900 m (map distance) from the pluton margin to the development of a pervasive emplacement‐related foliation adjacent to the pluton. The development of this pervasive foliation spanned all stages of crenulation cleavage development, which are preserved at different distances from the pluton. The spread of inclusion‐trail pitches in the staurolite porphyroblasts, as measured in two‐dimensional (2‐D) thin sections, increases nonlinearly from ～16° to 75° with increasing strain in the aureole. These data provide clear evidence for rotation of the staurolite porphyroblasts relative to one another and to the developing crenulation cleavage. The data spread is qualitatively modelled for both pure and simple shear, and both solutions match the data reasonably well. The spread of inclusion‐trail orientations (40–75°) in the moderately to highly strained rocks is similar to the spread reported in several previous studies. We consider it likely that the sample‐scale spread in these previous studies is also the result of porphyroblast rotation relative to one another. However, the average inclusion‐trail orientation for a single sample may, in at least some instances, reflect the original orientation of the overgrown foliation.  相似文献   

Seismic activity associated with the subducting motion of the Philippine Sea plate beneath the Kanto district, Japan   总被引：1，自引：1，他引：1  

Sadaki Hori 《Tectonophysics》2006,417(1-2):85

The Pacific plate and the Philippine Sea plate overlap and subduct underneath the Kanto region, central Japan, causing complex seismic activities in the upper mantle. In this research, we used a map selection tool with a graphic display to create a data set for earthquakes caused by the subducting motion of the Philippine Sea plate that are easily determined. As a result, we determined that there are at least four earthquake groups present in the upper mantle above the Pacific plate. Major seismic activity (Group 1) has been observed throughout the Kanto region and is considered to originate in the uppermost part of mantle in the subducted Philippine Sea plate, judging from the formation of the focal region and comparison with the 3D structure of seismic velocity. The focal mechanism of these earthquakes is characterized by the down-dip compression. A second earthquake layer characterized by down-dip extension (Group 2), below the earthquakes in this group, is also noted. The focal region for those earthquakes is considered to be located at the lower part of the slab mantle, and the Pacific plate located directly below is considered to influence the activity. Earthquakes located at the shallowest part (Group 3) form a few clusters distributed directly above the Group 1 focal region. Judging from the characteristics of later phases in these earthquakes and comparing against the 3D structure of seismic velocity, the focal regions for the earthquakes are considered to be located near the upper surface of the slab. Another earthquake group (Group 4) originates further below Group 2; it is difficult to consider these earthquakes within a single slab. The seismic activities representing the upper area of the Philippine Sea plate are Group 3. This paper proposes a slab geometry model that is substantially different from conventional models by strictly differentiating the groups.  相似文献