基于生物信息学探讨骨质疏松症与2型糖尿病的关系          下载免费PDF全文

葛殊玮  孙绍裘  彭广 《应用海洋学学报》2024,40(1):157

目的：基于生物信息学探讨骨质疏松症与 2 型糖尿病的关系。方法：通过基因表达汇编（GEO）数据库检索骨质疏松症和2型糖尿病的相关数据集,并筛选骨质疏松症-2型糖尿病共同差异表达基因,将数据导入STRING数据库找寻关键基因,以一个单细胞测序数据集作为检验集验证关键基因细胞层面的表达水平,对筛选结果进行基因本体（GO）功能及京都基因与基因组百科全书（KEGG）通路富集分析,并对关键靶点、相关中药进行频数统计及功效分类。结果：骨质疏松症与 2 型糖尿病相关通路集中在 ErbB信号通路、丝活化蛋白激酶（MAPK）信号通路、神经营养素信号通路、NOD样受体信号通路。频数统计结果显示,与骨质疏松症-2型糖尿病关键基因相关的中药有51味,以功效分类,可分为清热解毒药、止痛药、祛风药、补虚药、止呕药。结论：骨质疏松症和2型糖尿病都是复杂的代谢性疾病,涉及众多基因表达网络和信号通路。尽管两种疾病存在复杂的基因网络背景,但是分析结果表明两种疾病之间仍存在高度重合的差异基因表达和信号通路。这表明两种疾病的分子机制密切相关,可能存在共同调控的靶点,因此这些靶点可能成为药物同时干预两种疾病的治疗靶点。  相似文献   

东亚温带气旋及其长期预报（二）：预报应用分析     

战淑芸  杨淑瑞 《海洋预报》1995,12(1):26-30

本文以赤道东太平洋海温作为主导因子，分析其与东亚温带气旋的关系。得出：高海温多气旋，低海温少气旋的对应关系较为明显。并进一步对不符合这种主要关系的年份从环流型。下垫面海温等作了分类鉴别分析。  相似文献   

一种新的波浪变形三维数值模式──0-1混合型边界元   总被引：4，自引：0，他引：4  

孙大鹏  李玉成 《海洋学报》2000,22(3):44-48

为提高边界元法模拟三维波场波浪变形的数值计算精度,借鉴常数元和线性元剖分方式、波势函数及波势函数法向导数对单元节点设定的各自适应性,提出了一种新的单元剖分模式──0-1混合型边界元,以控制和减缓由于计算误差累计而造成的波浪数值计算上的“横向振动”,借此结合边界元法的分区模式可实现较大范围的波场线性波浪变形计算,并为时域内的波浪非线性变形计算提供时间步长的数值保证.  相似文献   

一种新型测向传感器——磁通门罗盘     

胡平  孟宪萍  江钩仁 《海洋与湖沼》1992,23(3):318-324

本文对磁通门罗盘的基本工作原理、实验线路以及主要技术指标和一些测量数据作简要介绍,最后对仪器的误差进行简单分析并提出一些减小误差的改进措施。  相似文献   

A New Pursuit Mode of Nonlinear Wave Surface     

孙大鹏李玉成  郭海滨 《中国海洋工程》2004,18(2):257-266

The numerical mode of nonlinear wave transformation based on both the Laplace equation for water field and the Bemoulli equation for water surface is a kind of time-domain boundary problem with initial conditions. And the basis for establishing the numerical mode of nonlinear wave in time domain is to trace the position of wave free surface and to calculale the instantaneous surface height and surface potential function. This paper firstly utilizes the ‘0-1‘ combined BEM to separate the boundary by means of discretization of Green‘ s integral equation based on the Laplace equation, then separates the free surface of wave with FEM and derives the FEM equation of wave surface that satisfies the nonlinear boundary conditions. By jointly solving the above BEM and FEM equations, the wave potential and surface height could be obtained with iteration in time domain. Thus a new kind of nonlinear numerical mode is established for calculating wave transformation. The wave test in the numerical wave tank shows that the numerical simulation with this mode is of high accuracy.  相似文献   

河口涨落潮槽水动力特征及河槽类型判定   总被引：4，自引：0，他引：4  

刘高峰  沈焕庭  吴加学  吴华林 《海洋学报》2005,27(5):151-156

在前人对河口冲刷槽研究的基础上,选择长江口南支、新桥水道、南小泓和南港主槽作为典型涨、落潮槽研究对象,以2001年洪季和2003年枯季实测资料为根据,比较分析了长江口涨落潮槽的水流、泥沙、优势流和优势沙等动力特征,结果表明用单一因子分析河槽性质不够全面.提出了一个(无量纲因子)河槽类型系数(λ)来综合表述河槽的多种水文泥沙特征,可以较全面地用多个影响因子来合理地判断河槽类型.  相似文献   

南沙西部海域伸缩型右旋走滑双重构造系统及其动力学过程   总被引：7，自引：1，他引：7  

刘海龄 《海洋地质与第四纪地质》1999,19(3):11-18

万纳断裂带为一典型的右旋走滑系统,由其南段前锋的拉奈—沙捞越走滑－收缩叠瓦扇、北段尾端的南海西南次海盆西南端走滑－伸展叠瓦扇和中段的万安盆地走滑－拉分双重构造所组成,其动力主要源自中生代末以来华南—印支陆缘岩石圈的拆沉作用和南海海底扩张,它的走滑拉分作用直接导致了万安盆地的产生,对该海域油气等资源的形成与聚集起了重要的控制作用。  相似文献   

Observation of clouds and solar radiation over the Pacific Ocean as relation to global climate     

Farn Parungo  Clarence Nagamoto  Cecilia M. I. R. Girz  Jeff Torgerson  Zhou Mingyu 《海洋学报(英文版)》1995,14(2):201-207

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Fractal Determination of Coastal Types Based on GIS--A Case Study of China     

Zhu xiaohua  WU Xiuqin  Wang Jian 《海洋通报(英文版)》2002,4(2)

The probability of fractal determination of coastal types based on GIS is preliminarily discussed with China as an example. Finally, some significant conclusions are drawn: (1) The fractal dimension of coastline of the bedrock coast is larger than that of the plain coast on the same scale map; (2) As far as the bedrock coast is concerned, the larger fractal dimension of coastline of the bedrock coast on the same scale map indicates that the bedrock coast is probably not typical; (3) As far as the plain coast is concerned, the smaller fractal dimension of coastline of the plain coast on the same scale map indicates that it is probably the silt plain coast; (4) The different substantial compositions affect the fractal dimensions of coastlines of different coastal types. In general, the coast which lies in the north of the Hangzhou Bay consists of sand mainly, its surface is flat, and it is connected with the coastal plain, its landform is broad shoal, its total change is comparatively homogenous in the tidal dynamic process, and thus, the relatively smaller fractal dimension of coastline results from this. For the bedrock coast, there is more bedrock, the coastline is comparatively smooth and straight, being affected by the faults and ocean dynamic process, which result in the larger fractal dimension.  相似文献   

The status of geological dredging techniques     

R. B. Kidd  Q. J. Huggett  A. T. S. Ramsay 《Marine Geophysical Researches》1990,12(1-2):131-143

Scientific sea-floor dredging is currently used in marine geology primarily by the hard-rock community interested in the recovery of basement rock samples from the unsedimented deep ocean floor. The technique has generally been eclipsed by ocean drilling for recovery of sedimentary rocks, because of perceived uncertainties in the location of sampling and in the representativeness of recovered material. This contribution reviews dredging equipment currently in use by marine geological institutions and refers to pinger attachments that allow precise information on the behaviour of the dredge to be telemetered back to the ship. We argue that improvements in ship navigation and transponder navigation at the seafloor, when used in conjunction with surface and/or deeply towed sidescan and swathemapping surveys, now allow for considerably less uncertainty on the location of dredge sampling. Refined sorting criteria for dredge hauls are now also available. Recent comparisons of regional sample recovery by ocean drilling and by dredge sampling indicate that the dredge hauls can usefully supplement the drilling data in the construction of sedimentary and tectonic histories of seafloor areas.  相似文献