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Global-local interaction is an important research topic in economic geography. In recent years, the rapid development of digitalization in various countries and regions has profoundly affected the global production and trade networks. However, there is a lack of systematic theoretical discussion on digitalization and global-local interaction studies. The objective of this study is to conceptually rethink the role of digitalization in reshaping global-local interactions from a dynamic and relational perspective. To do this, the study first systematically reviewed the digital turn in economic geography and discussed the rethinking of digitalization. It is found that the understanding of digitalization is gradually moving beyond the limits of isolated, static, and passive technocentric approaches and towards a more dynamic, relational, and open perspective. Second, the study combined the "digital turn" with the "relational turn" in relational economic geography, which constructs theoretical bridges between digitalization and global-local studies. Third, this study provided a basic understanding for sorting out the evolution of the research frameworks, that is, from the global value chain (GVC) to the global production network (GPN) and then to the digital ecosystem (DE). We argued that digitalization has been deeply involved in shaping the global economic landscape, restructuring global-local production relations, and reconstructing regional development. Based on this recognition, we discussed the primary performance of digitalization on the restructuring of global-local interaction from three aspects: enterprise relationship, spatial effect and interaction mechanism. Finally, grounded in the practice of China's urban and regional digital economy development, the possible theoretical innovations and prospects for future research on digitalization and global-local interaction in the Chinese context were proposed. The study pointed out that we can integrate the regional practices of China's digital development with more in-depth research from the perspectives of the platform ecosystems, spatial effects, location analysis, local development models, and so on in future research. © 2023, Editorial office of PROGRESS IN GEOGRAPHY. All rights reserved. 相似文献