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Xiutang Yuan Xiaolong Yang Anguo Zhang Xindong Ma Hui Gao Guangshui Na Humin Zong Guize Liu Yongguang Sun 《Marine pollution bulletin》2017,114(1):419-427
Spatial distribution, source apportionment, and potential ecological risks of sixteen polycyclic aromatic hydrocarbons (PAHs) and seven endocrine disrupting compounds (EDCs) in the intertidal sediment at the Shuangtaizi Estuary, Bohai Sea of China were analyzed. Results showed that the total PAH concentrations ranged from 28.79 ng g? 1 dw to 281.97 ng g? 1 dw (mean: 115.92 ng g? 1 dw) and the total EDC concentrations from 0.52 ng g? 1 dw to 126.73 ng g? 1 dw (mean: 37.49 ng g? 1 dw). The distribution pattern for the PAHs was generally different from that of the EDCs possibly due to their distinct sources and n-octanol-/water partition coefficients (KOW). Qualitative and quantitative analytical results showed that PAH sources were mainly from a mixture of pyrogenic and petrogenic contributions. The higher levels at the southeast of Geligang indicated that the EDC pollutants may have mainly originated from the plastic industry and other chemical plants located along the Liao River. Ecological risk assessment revealed that PAHs exhibited low ecotoxicological effects, whereas EDCs, especially 4-tert-octylphenol and bisphenol A, had high ecological hazard to the estuarine biota. 相似文献
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The occurrence of three endocrine disrupting compounds, 4-n-nonylphenol, triclosan and bisphenol A, was investigated in different bivalves originating from the Aegean Sea (Greece). The bioconcentration potential of these compounds was studied using the Mediterranean mussel (Mytilus galloprovincialis). Tissue samples were extracted by sonication. Analysis was performed by gas chromatography-mass spectrometry. According to the field survey results, the average concentrations of 4-n-nonylphenol, triclosan and bisphenol A, were 158, 461 and 404 ng g−1 (dry weight), respectively. During 28 days of exposure at 300 ng L−1, the tissue concentrations of compounds were constantly increased. Steady state was not observed up to the end of the experiment. Kinetic bioconcentration factors varied from 1.7 (4-n-nonylphenol and triclosan) to 4.5 L g−1 (bisphenol A). Following exposure, mussels were relocated to clean water for 28 days. This experiment revealed that depuration rates for all of the target compounds were lower than uptake rates. The biological half-lives of each compound ranged between 12 days (triclosan) and 26 days (bisphenol A). 相似文献
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模式生物秀丽隐杆线虫(Caenorhabditis elegans)具有繁殖速度快、世代周期短,通体透明、体细胞数目恒定,基因组小并被完全测序等优点,已经广泛地应用于生态毒理学研究。C.elegans的胚胎发育、蜕皮、繁殖等重要生理过程是通过激素调控的,外源激素的代谢产物可以作为核受体(NRs)的配体,C.elegans的寿命与胰岛素/胰岛素样生长因子信号(IIS)通路和固醇/类固醇信号通路密切相关。近年来已经建立了在分子、细胞、个体和种群水平上,利用vit-2、hsp、消化道与性腺、产卵数、胚胎发育时间、内禀增长率、性别比例等系统地筛选EDCs的指标体系。以C.elegans为模式生物,从线虫的蜕皮、IIS通路等角度探讨了EDCs对线虫寿命的影响及作用机制,并展望了C.elegans在EDCs导致的细胞增殖与细胞分化失调而诱发的癌症、糖尿病等研究中的应用前景。 相似文献
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M. Cristina Fossi Letizia Marsili Giancarlo Lauriano Caterina Fortuna Simone Canese Stefania Ancora Claudio Leonzio Teresa Romeo Ruben Merino Esteban Abad Begoa Jimnez 《Marine environmental research》2004,58(2-5):269
Various studies have revealed high concentrations of contaminants such as organochlorines (OCs) and heavy metals in Mediterranean cetaceans. A geographical trend of contamination (PCBs and DDTs) has been found for striped dolphin (Stenella coeruleoalba). In this study we used a non-lethal approach (skin biopsy) to investigate bioaccumulation of OCs, including polychlorobiphenyls (PCBs), DDTs, polychlorodibenzo-p-dioxins (PCDDs), polychlorodibenzofurans (PCDFs), trace elements (Hg, Cd, Pb) and CYP1A activity (BPMO) in nine striped dolphins sampled in the Aeolian area (Sicily – Italy) in summer 2002. The arithmetic mean value of BPMO activity in this group was 43.46 AUF/g tissue/h. This value is approximately 3 times and 5 times lower, respectively, than the value found in the Ionian and in the Ligurian groups. Skin biopsies of striped dolphins emerged as a suitable material for assessing the toxicological status of the various Mediterranean groups. 相似文献
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Endocrine disrupting chemicals (EDCs) are increasingly viewed as persistent pollutants, similar to natural hormones in function. This paper describes the expression profiles of 7 genes (DMRT, VTG, GnRHR, FSHR, CYP17A, CYP19A, and CYP19B) involved in sex steroid synthesis and action as well as sexual development in adult male and female Cynoglossus semilaevis, after exposure to different concentrations of Bisphenol A (BPA) and 17β-estradiol (E2). Both BPA (1, 10, 50, 125, and 250 mg/kg) and E2 (0.5, 5, and 10 mg/kg) induced changes in target gene expression, although the estrogenic effects of E2 as a model estrogen were stronger. Among the 7 genes, VTG, CYP17A and CYP19 responded strongly to BPA or E2 exposure and can thus serve as reference biomarkers for estrogenic EDCs exposure in marine teleosts. These data will provide a window to establish a hypothalamic-pituitary-gonadal model in C. semilaevis to better understand the effect pathways of EDCs. 相似文献
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Biomarkers for endocrine disruptors in three species of Mediterranean large pelagic fish 总被引：2，自引：0，他引：2
Fossi MC Casini S Marsili L Neri G Mori G Ancora S Moscatelli A Ausili A Notarbartolo-di-Sciara G 《Marine environmental research》2002,54(3-5):667-671
The hypothesis that Mediterranean top predator species, such as large pelagic fish, are potentially at risk due to endocrine disrupting chemicals (EDCs), is investigated. The potential estrogenic effects of PHAHs in three fish species of commercial interest, the top predators bluefin tuna (Thunnus thynnus thynnus), swordfish (Xiphias gladius), and Mediterranean spearfish (Tetrapturus belone), were investigated using vitellogenin (Vtg), zona radiata proteins (Zrp) and mixed function oxidases (EROD, BPMO) as diagnostic tools. High induction of Vtg and Zrp was detected by western blot and ELISA techniques in adult males of X. gladius and T. thynnus thynnus, suggesting that these species are at high toxicological risk in the Mediterranean sea. Comparison of BPMO and EROD activities in the three species indicated, both in male and female, much higher MFO activity in bluefin tuna. This data suggests high exposure of this species to lipophilic xenobiotic contaminants in the Mediterranean environment. 相似文献
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M. Cristina Fossi Silvia Casini Stefania Ancora Alessandra Moscatelli Antonella Ausili Giuseppe Notarbartolo-di-Sciara 《Marine environmental research》2001,52(5)
Endocrine Disrupting Chemicals (EDCs) have the potential to alter hormone pathways that regulate reproductive processes in wildlife and fishes. In this research the hypothesis that Mediterranean top predator species (such as large pelagic fish) are potentially at risk due to EDCs is investigated. These marine organisms tend to accumulate high concentrations of EDCs such as polyhalogenated aromatic hydrocarbons (PHAHs). The potential effects of EDCs on a fish species of commercial interest, the top predator Xiphias gladius (swordfish), were investigated using vitellogenin (Vtg) and Zona radiata proteins (Zrp) as diagnostic and prognostic biomarkers. Dramatic induction of typically female proteins (Vtg and Zrp) was detected by ELISA and Western Blot in adult males of the species. These results are the first warning of the potential risk for reproductive function of Mediterranean top predators, and suggest the need for continuous monitoring of this fragile marine environment. 相似文献
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Stefanelli P Ausili A Di Muccio A Fossi C Di Muccio S Rossi S Colasanti A 《Marine pollution bulletin》2004,49(11-12):938-950
Polychlorobiphenyls (PCB) and organochlorine (OC) pesticides are endocrine-disrupting chemicals (EDCs). The Italian Ministry of Environment has undertaken a program (1999-2001) to measure levels of contaminants in top marine predators and to develop sensitive biomarkers for the evaluation of toxicological risk in these species. In 1999, 15 swordfishes (Xiphias gladius) taken from the Mediterranean Sea along the Sicilian coast (Strait of Messina, Italy) and in the Atlantic Ocean along the Azores Islands, and analysed for 34 congeners of PCBs and 27 organochlorine (OC) pesticides in gonad, muscle, liver and blubber tissues. In the tissues of Mediterranean swordfishes the sum of the determined PCBs congeners ranged from 4.61 to 4651.17 ng g(-1) on fresh tissue basis. Among organochlorine pesticides DDE, DDT and DDD (TDE) predominated with an overall range of 2.37-4734.56 ng(-1) w.w. In particular p,p'-DDE had concentrations appearing up to 3900 ng(-1), with the highest values found in fatty tissues, such as blubber. In the liver of Azores Island swordfishes lower levels of summation PCBs (8.43-294.17 ng/g w.w.) and summation DDTs (<0.01-217.44 ng/g w.w.) were determined. 相似文献
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采用单"克隆"培养和群体培养的方法,研究了具有环境雌激素效应药物氰戊菊酯(Fenvalerate)和雌性雄性化激素效应药物三丁基氯化锡(TBTC)对萼花臂尾轮虫(Brachionus calyciflorus)生命周期中各发育阶段的历时以及种群增长的影响,结果表明,氰戊菊酯和TBTC对萼花臂尾轮虫的生长发育和种群增长有明显的效应,氰戊菊酯使生殖期延长(200和1000μg/L),生殖后期缩短,平均寿命也缩短(除1000μg/L),总产卵量和种群增长率升高;而经TBTC处理生殖前期延长(1和5μg/L),生殖期和生殖后期缩短,平均寿命也缩短,总产卵量和种群增长率较对照组也有下降,批次携卵量也受到两种药物的影响,且萼花臂尾轮虫的总产卵量随着氰戊菊酯和TBTc的浓度呈曲线相关,氰戊菊酯:Y=-0.6745X2+6.6884X+5.855(R2=0.7027);TBTC:Y=0.2054X2-2.3 178X+16.666(R2=0.6535),研究表明环境雌激素氰戊菊酯和雌性雄性化激素TBTC对萼花臂尾轮虫生活史特征影响表现出一定差异. 相似文献
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