Differential developmental toxicity of naphthoic acid isomers in medaka (Oryzias latipes) embryos   总被引：1，自引：0，他引：1  

Michael W. Carney  Kyle Erwin  Ron Hardman  Bonny Yuen  David C. Volz  David E. Hinton  Seth W. Kullman   《Marine pollution bulletin》2008,57(6-12):255

Polycyclic aromatic hydrocarbons (PAHs) are widespread persistent pollutants that readily undergo biotic and abiotic conversion to numerous transformation products in rivers, lakes and estuarine sediments. Here we characterize the developmental toxicity of four PAH transformation products each structural isomers of hydroxynaphthoic acid: 1H2NA, 2H1NA, 2H3NA, and 6H2NA. Medaka fish (Oryzias latipes) embryos and eleutheroembryos were used to determine toxicity. A 96-well micro-plate format was used to establish a robust, statistically significant platform for assessment of early life stages. Individual naphthoic acid isomers demonstrated a rank order of toxicity with 1H2NA > 2H1NA > 2H3NA > 6H2NA being more toxic. Abnormalities of circulatory system were most pronounced including pericardial edema and tube heart. To determine if HNA isomers were AhR ligands, spatial-temporal expression and activity of CYP1A was measured via in vivo EROD assessments. qPCR measurement of CYP1A induction proved different between isomers dosed at respective concentrations affecting 50% of exposed individuals (EC50s). In vitro, all ANH isomers transactivated mouse AhR using a medaka CYP1A promoter specific reporter assay. Circulatory abnormalities followed P450 induction and response was consistent with PAH toxicity. A 96-well micro-plates proved suitable as exposure chambers and provided statistically sound evaluations as well as efficient toxicity screens. Our results demonstrate the use of medaka embryos for toxicity analysis thereby achieving REACH objectives for the reduction of adult animal testing in toxicity evaluations.  相似文献   

Elemental mercury concentrations and formation rates in the Scheldt estuary and the North Sea     

W. Baeyens  M. Leermakers 《Marine Chemistry》1998,60(3-4)

Concentrations of Hg⁰ in surface waters and atmosphere of the Scheldt estuary and the North Sea are presented and their relationship with biological processes is discussed. Hg⁰ concentrations in the Scheldt estuary range from 0.1 to 0.38 pmol·l⁻¹ in the winter and from 0.24 to 0.65 pmol·l⁻¹ in the summer and show a positive relationship with phytoplankton pigments. In the North Sea Hg⁰ concentrations range from 0.06 to 0.8 pmol·l⁻¹ and are higher in coastal stations. Transfer velocities across the air–sea interface were calculated using a classical shear turbulence model. Volatilization fluxes of Hg⁰ were calculated for the Scheldt estuary and the North Sea. For the Scheldt estuary the fluxes range from 226–284 pmol·m⁻²·d⁻¹ in winter and 500–701 pmol·m⁻²·d⁻¹ in summer and for the North Sea the fluxes range from 59–1110 pmol·m⁻²·d⁻¹ for an average windspeed of 8.1 m·s⁻¹. These fluxes are comparable to the wet and dry depositional fluxes to the North Sea. Hg⁰ formation rates necessary to balance the volatilization fluxes vary from 0.2 to 4% d⁻¹.  相似文献   

一种新的超声波心动图像分割算法     

张弸  罗代升  周雪莲 《成都信息工程学院学报》2007,22(3):297-300

针对超声心动图像噪声大,边界模糊,灰度分布不均匀等特点,提出了一种新的图像分割算法.首先对超声图像进行滤波和边缘锐化等预处理,然后再使用GVFSnake模型对预处理后的图像进行分割,从而提取出心室的边界.经试验证明,这种新的超声心动图像分割算法,比传统的超声图像分割算法在图像分割精度上有显著的提高.  相似文献   

利用复测水准资料寻求反映地壳纯形变的定量指标     

崔笃信 《大地测量与地球动力学》1994,(1)

地壳纯变形分为剪切变形和扩张变形。在前人研究的基础上提出了仅利用复测水准资料求出描述地壳剪切变形和扩张变形指标的方法和步骤，所得的定量指标不受基准的影响，受测量累积误差的影响亦很小，能客观地反映地壳变形的特征。通过理论和实例证明：以一点周围变形分量的最大值代表该点周围垂直面的变形程度比其平均值更能突出变形信息。最后根据实例计算结果分析了剪切变形分量、扩张变形分量与形变速率、构造地震的关系。  相似文献   

Proterozoic fluvial styles: response to changes in accommodation space (Rivieradal sandstones, eastern North Greenland)     

Martin S  nderholm  Henrik Tirsgaard 《Sedimentary Geology》1998,120(1-4):257-274

Fluvial styles recorded by the uppermost part of the Neoproterozoic ‘Rivieradal sandstones' succession of eastern North Greenland reflect variations in rate of generated accommodation space and possibly climatic changes. Three facies associations, arranged in two genetic sequences, are recognised within the succession. The lower sequence initially records little available accommodation space. A high degree of reworking results in sheet-like, high-energy, bed-load-dominated, braided river deposits lacking recurrent facies patterns. As accommodation space increases upwards through the sequence, reduction in reworking is recorded by the development of fining- and thickening-upward muddy fluvial cycles. Evidence of desiccation or prolonged periods of drought are absent within the deposits and climate was probably relatively humid. Channel deposits in the lower sequence reflect mixed-load, braided fluvial systems with stable channel banks and floodplains, and the gradient appears to have been low to moderate. These features are generally considered favourable for the establishment of meandering river systems, but channels, nevertheless, retained an overall braided character and their deposits show no evidence of meandering. Despite indications of a climatic setting without significant periods of drought sediments indicate that large fluctuations in discharge occurred within the mixed-load streams and this is suggested to be the main cause for the absence of meandering. The swift and rather dramatic response of the fluvial systems to changes in precipitation, probably resulted from rapid runoff rates caused by the absence of vegetation. The upper sequence shows an initial return to shallow, sandy braided river deposition recording little available accommodation space. A subsequent increase in the rate of generated accommodation space is indicated by the presence of alternating sheet sandstones and sand-streaked mudstones with abundant desiccation cracks. The sheet sandstones show evidence of high-energy, unconfined ephemeral fluvial flash-flood deposition, while the mudstones are interpreted to represent muddy floodplain deposits. The change in fluvial style, combined with the widespread evidence of desiccation, suggest an evolution towards a more semi-arid climate in the upper sequence. This climatic change could account for the reduced clastic input seen in the overlying marine succession which culminated in carbonate platform deposition. The present study suggests that even under conditions considered favourable for the formation of meandering streams, these will rarely occur in Proterozoic deposits due to the lacking influence of vegetation. Although meandering deposits cannot be ruled out as having formed in pre-vegetational times, the conditions for their formation appear to have been even more restricted than previously realised.  相似文献   

Controls on spatial and temporal distribution of Precambrian eolianites     

Kenneth A. Eriksson  Edward L. Simpson 《Sedimentary Geology》1998,120(1-4):275-294

Inversely graded stratification, generated by the migration of wind ripples, and adhesion structures permit unequivocal identification of Precambrian eolianites. These criteria, in combination with scale of cross-beds, angle of inclination of foresets, geometry of depositional units, and associated non-eolian facies, are used to discriminate between Precambrian dune/draa, dune-plinth, sand-sheet, and interdune deposits that formed in inland and coastal settings. Based on an analysis of published literature, fundamental conclusions can be drawn on the spatial and temporal distribution of Precambrian eolianites. The oldest reported eolianites are from the ca. 2.1 Ga Deweras Group in Zimbabwe and Hurwitz Group in Canada and numerous examples of eolianites are reported from the 1.8 Ga and younger rock record. Lack of Archean and early Paleoproterozoic eolianites and their widespread development after 1.8 Ga are examined with respect to: absence of vegetation, crustal growth and tectonic setting, relative sea-level fluctuations, unfavorable atmospheric and/or climatic change, and non-recognition. The lack of pre-2.2 Ga eolianites may be related to reworking by braided rivers combing across non-vegetated floodplains, reworking of coastal eolianites during transgression or their non-recognition in the Early Precambrian record. The temporal concentration of eolianites at 1.8 Ga may best be related to the early stages of breakup and the assembly phases of supercontinents.  相似文献   

Preservation of pre-vegetational mixed fluvio–aeolian deposits in a humid climatic setting: an example from the Middle Proterozoic Eriksfjord Formation, Southwest Greenland     

Henrik Tirsgaard  Ingrid E. I. xnevad 《Sedimentary Geology》1998,120(1-4):295-317

Sedimentological studies of a 30 m thick coastal cliff section within the Middle Proterozoic Eriksfjord Formation in western South Greenland reveals three distinct types of fluvial sand sheet deposits that reflect perennial streams (Type I), semi-perennial streams (Type II), and ephemeral flash floods (Type III). Perennial river sand sheets are characterised by co-sets of medium-scale trough cross-beds, interbedded with isolated medium- and large-scale, high-angle, tabular cross-beds. Indications of desiccation or subaerial exposure are absent. Semi-perennial fluvial sand sheets consist predominantly of low-angle cross-beds, interbedded with isolated sets of high-angle tabular cross-beds with common reactivation surfaces. Horizontal lamination and climbing ripple lamination form subordinate structures. Associated with the sand sheets are adhesion structures and 0.05–0.4 m thick sets of wind ripple-lamination indicating periods of subaerial exposure and aeolian reworking. High-energy ephemeral flash flood sand sheets consist almost exclusively of planar-parallel lamination and climbing ripple lamination with some isolated sets of low-angle cross-bedding. Scouring and internal truncation surfaces are common. The three types of sand sheets are considered to reflect deposition under changing climatic conditions, varying from humid to arid or semi-arid. Aeolian deposits are preserved within the sand sheets showing characteristics of dominantly perennial flow punctuated by shorter periods of desiccation (Type II), while sand sheets showing features typical of arid and or semi-arid flow conditions (Type III) contain no preserved aeolian deposits. This selective preservation is interpreted to be a result of the combined effect of groundwater table level and fluvial style which in turn are inferred to have been controlled by the climatic regime. The deposits show that during pre-vegetational times the preservation of aeolian deposits, under certain conditions, may be more optimal in fluvial systems formed in a humid climate than in fluvial systems formed under semi-arid or arid circumstances. The occurrence of aeolian deposits within a Precambrian succession of fluvial deposits therefore, need not be an indication of the most arid environmental conditions.  相似文献   

Precambrian tidal and glacial clastic deposits: implications for Precambrian Earth–Moon dynamics and palaeoclimate     

George E. Williams 《Sedimentary Geology》1998,120(1-4):55-74

Over the past decade the study of Precambrian clastic tidal rhythmites — stacked laminae of sandstone, siltstone and mudstone that display periodic variations in thickness reflecting a strong tidal influence on sedimentation — has provided accurate palaeotidal and palaeorotational data. Palaeotidal records obtained from tidal rhythmites may be systematically abbreviated, however, and derived periods and frequencies can be misleading. The validity of such values, including past length of day, can be assessed by testing for internal self-consistency through application of the laws of celestial mechanics. Such a test supports the estimated length of day of h derived from the late Neoproterozoic (620 Ma) Elatina–Reynella rhythmites in South Australia, and the indicated mean rate of lunar retreat of cm/year since 620 Ma. The validity of estimated lengths of day obtained from other Precambrian tidal rhythmites remain unverified because the data sets contain only one primary value directly determined from the rhythmites. The Elatina–Reynella data militate against significant Earth expansion at least since 620 Ma, and suggest that the free nutation or ‘tipping' of the Earth's fluid core has undergone a resonance with the Earth's annual forced nutation since the Neoproterozoic. Glaciogenic deposits are readily distinguishable from ejecta resulting from impacts with Earth-crossing bodies. Palaeomagnetic data, based on the geocentric axial dipole model for the geomagnetic field, indicate that Neoproterozoic and Palaeoproterozoic glaciation and cold climate near sea level occurred in low palaeolatitudes. This enigmatic finding may imply global glaciation or an increased obliquity of the ecliptic, and is relevant to modelling the effect of ice sheet formation on the Earth's obliquity history by obliquity–oblateness feedback mechanisms. Through multidisciplinary studies, clastic sedimentology and geophysics together can make substantial contributions to understanding Precambrian Earth–Moon dynamics and global palaeoenvironments.  相似文献   

矿泉水常识问答     

葛文彬  杨敏 《四川地质学报》2008,28(2):160-163

矿泉水中的饮用天然矿泉水在地下深循环条件下形成,化学成分稳定,水源卫生,细菌学指标安全。有一定含量的矿物盐、微量元素或二氧化碳气体,作为一种天然饮料,是其他饮用水无法比拟的,无须医生指导,长期饮用也不会对人体产生危害。  相似文献   

浅谈纯住宅楼梯的进深与合理布置     

简小燕 《中国勘察设计》2009,(3):53-55

住单元楼的人可能每天都在往来于住宅楼梯间,作为一种不可缺少的交通工具,对人的行为起作很重要的作用。随着社会的发展,住户对住宅楼梯间的感知也越来越不同,在设计上我们应将它设计得更加合理、严谨、优化、规范化、科学化,让它成为更具人性化的交通工具。  相似文献