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1.
目的：观察三香通络饮联合苯磺酸氨氯地平片治疗老年性高血压病的临床疗效。方法：将92 例老年性高血压病患者按随机数字表法分为治疗组和对照组,每组各46 例。对照组口服苯磺酸氨氯地平片治疗,治疗组在对照组基础上加用三香通络饮治疗。比较2组的综合疗效、中医证候积分及不良反应发生情况。结果：总有效率治疗组为89.13%（41/46）,对照组为60.87%（28/46）,2组比较,差异有统计学意义（P<0.05）;2组各项中医证候积分治疗前后组内比较,差异均有统计学意义（P<0.05）,且治疗后头晕目眩、头痛、心悸、口干口苦评分组间比较,差异均有统计学意义（P<0.05）;不良反应发生率治疗组为10.87%（5/46）,对照组为19.57%（9/46）,2组比较,差异无统计学意义（P>0.05）。结论：三香通络饮联合苯磺酸氨氯地平片治疗老年性高血压病患者的临床疗效优于单用西药治疗,且能有效减轻临床症状,值得推广。 相似文献
2.
Th. F. Wever F. Abegg H. M. Fiedler G. Fechner I. H. Stender 《Continental Shelf Research》1998,18(14-15)
The seafloor of central Eckernförde Bay is characterised by soft muddy sediments that contain free methane gas. Bubbles of free gas cause acoustic turbidity which is observed with acoustic remote sensing systems. Repeated surveys with subbottom profiler and side scan sonar revealed an annual period both of depth of the acoustic turbidity and backscatter strength. The effects are delayed by 3–4 months relative to the atmospheric temperature cycle. In addition, prominent pockmarks, partly related to gas seepage, were detected with the acoustic systems. In a direct approach gas concentrations were measured from cores using the gas chromatography technique. From different tests it is concluded that subsampling of a core should start at its base and should be completed as soon as possible, at least within 35 min after core recovery. Comparison of methane concentrations of summer and winter cores revealed no significant seasonal variation. Thus, it is concluded that the temperature and pressure influences upon solubility control the depth variability of acoustic turbidity which is observed with acoustic remote sensing systems. The delay relative to the atmospheric temperature cycle is caused by slow heat transfer through the water column. The atmospheric temperature cycle as ‘exiting function’ for variable gas solubility offers an opportunity for modelling and predicting the depth of the acoustic turbidity. In practice, however, small-scale variations of, e.g., salinity, or gas concentration profile in the sediment impose limits to predictions. In addition, oceanographic influences as mixing in the water column, variable water inflow, etc. are further complications that reduce the reliability of predictions. 相似文献
3.
Acoustic turbidity caused by the presence of gas bubbles in seafloor sediments is a common occurrence worldwide,but is as yet poorly understood. The Coastal Benthic Boundary Layer experiment in the Baltic off northern Germany was planned to better characterize the acoustic response of a bubbly sediment horizon. In this context, in situ measurements of compressional wave speed and attenuation were made over the frequency range of 5–400 kHz in gassy sediments of Eckernförde Bay. Dispersion of compressional speed data was used to determine the upper limit of the frequency of methane bubble resonance at between 20 and 25 kHz. These data, combined with bubble size distributions determined from CT scans of sediments in cores retained at ambient pressure, yield estimates of effective bubble sizes of 0.3–5.0 mm equivalent radius. The highly variable spatial distribution of bubble volume and bubble size distribution is used to reconcile the otherwise contradictory frequency-dependent speed and attenuation data with theory. At acoustic frequencies above resonance (>25 kHz) compressional speed is unaffected by bubbles and scattering from bubbles dominates attenuation. At frequencies below resonance (<1 kHz) ‘compressibility effects’ dominate, speed is much lower (250 m s-1) than bubble-free sediments, and attenuation is dominated by scattering from impedance contrasts. Between 1.5 and 25 kHz bubble resonance greatly affects speed and attenuation. Compressional speed in gassy sediments (1100–1200 m s-1) determined at 5–15 kHz is variable and higher than predicted by theory (<250 m s-1). These higher measured speeds result from two factors: speeds are an average of lower speeds in gassy sediments and higher speeds in bubble-free sediments; and the volume of smaller-sized bubbles which contribute to the lower observed speeds is much lower than total gas volume. The frequency-dependent acoustic propagation is further complicated as the mixture of bubble sizes selectively strips energy near bubble resonance frequencies (very high attenuation) allowing lower and higher frequency energy to propagate. It was also demonstrated that acoustic characterization of gassy sediments can be used to define bubble size distribution and fractional volume. 相似文献
4.
目的：基于网络药理学研究附子-细辛对高血压病的作用机制。方法：运用TCMSP数据库挖掘出附子-细辛的有效成分及药物预测靶点,采用5个生物信息数据库检索出高血压病的疾病预测靶标,构建药物靶点-疾病靶标交集,使用Cytoscape生物信息分析软件绘制“成分-靶点-疾病”中药调控网络,基于STRING数据库构建“药物-疾病”相关靶点的蛋白互作网络（PPI）,并对其进行GO和KEGG的生物信息学分析。结果：通过生物利用度和类药性筛选得到附子-细辛的有效成分29个,对应药物靶点1807个,高血压病的疾病靶标8505个,构建的药物靶点-疾病靶标交集80个。与高血压病密切相关的GO富集条目91个,KEGG信号通路123条,主要涉及流体剪切应力与动脉粥样硬化、糖尿病并发症中的AGE-RAGE信号通路、白细胞介素（IL）-17信号通路、丝裂原活化蛋白激酶（MAPK）信号通路、PI3K-Akt信号通路等。结论：附子-细辛药对与高血压病密切相关,能够通过一条或多条通路协同发挥药效作用,考虑其可能是通过干预血液的流体剪切应力影响动脉粥样硬化与心血管重塑再生而实现的。 相似文献
5.
目的:应用野百合碱(MCT)诱导建立大鼠肺动脉高压(PAH)模型,运用微型CT和磁共振心功能成像方法,研究肺动脉压力演变和右心室结构、功能演变之间的关系。材料与方法:将MCT诱导的PAH模型组(1 wk-PAH组、2 wk-PAH组、3 wk-PAH组、4 wk-PAH组)和每一个模型组的对照组大鼠分别随机分组(每小组12只),分别在第1、2、3和4周右心导管测量肺动脉压力,微型CT测量主肺动脉直径及右心室与左心室最大径比值,MRI右心功能动态检测,观察肺动脉压力和MRI参数演变关系。比较对照组、PAH模型组各组间的相关各参数差异。采用SPSS 17.0统计软件,应用Pearson相关性分析,评价右心室射血分数,右室舒张末期容积,右室收缩末期容积,右心室与左心室最大径比值和主肺动脉直径分别与平均肺动脉压的相关性,组间比较采用完全随机分组的t检验,P<0.05为差异具有统计学意义。结果:注射野百合碱后1至4周,48只模型组大鼠的右心室射血分数、右心室舒张及收缩末期容积与平均肺动脉压有很好的相关性(分别为rRVEF=-0.823,rRVEDV=0.732,rRVESV=0.803)。右心室与左心室最大径比值与平均肺动脉压有轻度相关(r=0.694),主肺动脉直径与平均肺动脉压无相关性,r=0.438。注射野百合碱前两周,野百合碱组大鼠的平均肺动脉压、射血分数、右室舒张末期和收缩末期容积、右心室与左心室最大径比值与对照组比较未见显著差异(P>0.05)。3周到4周后,以上各参数与对照组比较有显著性差异(P<0.05)。结论:随着大鼠的肺动脉压增高,右心室与左心室最大径比值增加,右心室射血分数逐渐降低,右心室舒张末期及收缩末期容积逐渐增加。对于大鼠慢性肺动脉高压模型的监测,CT和MRI可以准确快速测量各项参数变化,简单易行。右心室舒张末及收缩末期容积、射血分数等参数是提示肺动脉高压的敏感参数。 相似文献
6.
多层螺旋CT作肾动脉造影在高血压筛查中的临床应用价值 总被引：2，自引：0，他引：2
目的:评价多层螺旋CT(multislice computed tomography MSCT)血管造影(CT angiography,CTA)在肾血管性高血压筛查中的临床应用价值.方法:对157例临床怀疑肾动脉狭窄患者行多层螺旋CT肾动脉CTA检查,将获得的轴位扫描图像经过适当处理后,行3D后处理,包括SSD、MIP、VR,MPVR.结果:157例患者均获得了较满意的肾动脉CTA图像,清晰地显示肾动脉主干及其分支.结论:MSCT肾动脉CTA检查作为一种安全、经济的检查方法,在对肾血管性高血压的筛查中完全可以替代DSA,常规作为怀疑肾动脉狭窄之患者的筛选检查的首选方法. 相似文献
7.
模拟寒潮对高血压疾病的影响实验研究 总被引：1，自引：0，他引：1
本文通过动物实验初步探讨了寒潮天气发生过程中对高血压疾病的影响。在张书余等(2013)研究的基础上,应用FEM1880气象环境模拟箱模拟寒潮温压变化,将27只健康大鼠按每组3个随机分为9组,分别为空白对照组、最低温前3 h组、最低温前1 h组、最低温组、最低温后1 h组、最低温后3 h组、全过程结束组、全过程结束后5 h组和全过程结束后7 h组,放入模拟箱内,使其受寒潮天气影响,按照寒潮天气过程发生的不同时间先后分批取出实验大鼠,测量各组大鼠的收缩压、心率、体重,并通过腹主动脉采血测量血脂、去甲肾上腺素、血管紧张素Ⅱ及全血粘度等。实验结果分析表明,在寒潮天气发生过程中,冷锋通过后,受冷高压控制,气温迅速下降,当气温达到最低时,全血粘度、去甲肾上腺素和血管紧张素Ⅱ等上升到最大值,致使健康大鼠血压升高,并维持到寒潮天气影响结束以后还不能立刻恢复正常。 相似文献
8.
To understand the origin of the methane distributions in sediments of Eckernförde Bay, three sites were sampled in May 1994 for determination of methane, sulfate and chloride concentrations in the sediment porewaters. In much of the Bay, bubbles of biogenic methane gas within the sediments lead to widespread ‘acoustic turbidity’ seen in acoustic surveys, masking the sedimentary structure below the gassy horizon. Acoustic windows, where the gas does not appear to be present, occur in several locations in the Bay, often surrounded by acoustically turbid sediments. Pockmarks, shallow depressions in the sediment, are also found in Bay sediments and may show acoustic turbidity at even shallower depths below the interface than surrounding sediments. One site of each type was sampled in this study. The site probably representative of much of the bay below 20 m water depth, revealed methane saturated conditions by about 75 cm depth below the interface, confirming inferences from acoustic scattering data that free gas was present in the sediment. Above this, the methane concentration profile was concave-upward, indicative of methane oxidation in the overlying, sulfate-reducing sediments. These porewaters showed a slightly decreasing chlorinity with depth. At an acoustic window site, methane concentrations rose to a maximum at about 125 cm depth, but did not reach saturation. Below this depth they decreased in a concave-down pattern. Chloride concentrations decreased markedly with depth, indicative of vertical freshwater flow from below. The third site was a pockmark exhibiting very shallow acoustic turbidity at about 25 cm depth. Here methane concentrations rose to exceed saturation within 25 cm depth below the interface and the porewaters became almost fresh by 1.5 m depth, indicative of a stronger flow of freshwater from below. These groundwater flows have competing effects on the methane inventory. They help exclude sulfate from the sediment, allowing the earlier/shallower onset of methanogenesis, but they also aid loss of methane through advection. A diagenetic model that couples the biogeochemistry of sulfate and methane is used to explain the presence or absence of methane gas in these sediments in relation to the flow rate of fresh groundwater from below. Model results indicate that acoustic windows within otherwise acoustically turbid sediments of the bay are likely due to relatively higher rates of vertical advection of fresh groundwater. The gassy pockmark, however, with an even higher vertical advection rate, seems to require the input of additional reactive organic carbon to explain its vertical methane distribution. 相似文献
9.
The organically rich, fine-grained, very soft, high porosity sediments in the inner portion of Eckernförde Bay, Germany have varying amounts of methane gas, with the horizon of gas fluctuating vertically on a seasonal cycle. The sharp vertical gradient in water content, with values exceeding 500% at the sediment–water interface, and corresponding gradient in density can be expected to cause a significant subbottom acoustic impedance contrast in these surficial sediments. Equations are presented to characterize geotechnical property variations of the upper 5 m. The upper 1.5 m exhibits appreciable ‘apparent’ overconsolidation with a trend toward a normally consolidated stress state at 2.5 m depth. The coefficient of permeability of the upper 40 cm is low (4×10-6 cm s-1) and the sediment is highly compressible with compression indices of 2.7–6.8. Triaxial compression test results indicate that the sediment behaves as a normally consolidated clay with a low friction angle (22°). The rheological behavior of the upper 20–30 cm, determined with a small vane device, is indicative of a shear-thinning material, implying that the resistance to penetration decreases with increasing velocity. 相似文献
10.
目的：研究补肺养心汤对冠心病心力衰竭患者中医证候及心功能的影响。方法：将94 例冠心病心力衰竭患者按随机数字表法分为治疗组和对照组,每组各47 例。对照组予以螺内酯、呋塞米、阿司匹林肠溶片等常规西药治疗,治疗组在对照组基础上联合补肺养心汤治疗,2组均以4周为1个疗程,共治疗3个疗程。治疗后比较2组的中医证候（心悸、气短、胸胁作痛）积分及心功能指标左心室射血分数（LVEF）、左心室收缩末期内径（LVESD）及左心室舒张末期内径（LVEDD）变化。结果：总有效率治疗组为85.11%（40/47）,高于对照组的63.83%（30/47）,差异有统计学意义（P＜0.05）;治疗后2组患者心悸、气短、胸胁作痛等中医证候积分及LVEDD、LVESD水平较治疗前降低,LVEF水平较治疗前升高,且治疗组改善幅度较对照组更为明显（均P＜0.05）。结论：补肺养心汤可有效缓解冠心病心力衰竭患者的临床症状,改善心功能,促进病情恢复。 相似文献