Use of suppressive subtractive hybridization and cDNA arrays to discover patterns of altered gene expression in the liver of dihydrotestosterone and 11-ketotestosterone exposed adult male largemouth bass (Micropterus salmoides)     

Blum JL  Knoebl I  Larkin P  Kroll KJ  Denslow ND 《Marine environmental research》2004,58(2-5):565-569

In this study male largemouth bass (LMB) were exposed to the naturally occurring androgens, dihydrotestosterone (DHT) or 11-ketotestosterone (11-KT) in order to identify genes that are differentially regulated by these steroid hormones. Using subtractive hybridization on livers of fish treated with DHT against vehicle control, many novel LMB genes were cloned. These genes were added to our gene library and arrayed. Six genes were up-regulated and five were down-regulated by both androgens. But, each androgen also regulated specific genes. One gene that was identified as a potential androgen marker was spermidine-spermine-N(1)-acetyltransferase that was up-regulated by both androgens. Determining which genes are responsive to natural androgens will help to identify biochemical pathways that are impacted.  相似文献   

Polycyclic aromatic hydrocarbons (PAHs) in Antarctic Martian meteorites, carbonaceous chondrites, and polar ice     

Becker L  Glavin DP  Bada JL 《Geochimica et cosmochimica acta》1997,61(2):475-481

Recent analyses of the carbonate globules present in the Martian meteorite ALH84001 have detected polycyclic aromatic hydrocarbons (PAHs) at the ppm level (McKay et al., 1996). The distribution of PAHs observed in ALH84001 was interpreted as being inconsistent with a terrestrial origin and were claimed to be indigenous to the meteorite, perhaps derived from an ancient martian biota. We have examined PAHs in the Antarctic shergottite EETA79001, which is also considered to be from Mars, as well as several Antarctic carbonaceous chondrites. We have found that many of the same PAHs detected in the ALH84001 carbonate globules are present in Antarctic carbonaceous chondrites and in both the matrix and carbonate (druse) component of EETA79001. We also investigated PAHs in polar ice and found that carbonate is an effective scavenger of PAHs in ice meltwater. Moreover, the distribution of PAHs in the carbonate extract of Antarctic Allan Hills ice is remarkably similar to that found in both EETA79001 and ALH84001. The reported presence of L-amino acids of apparent terrestrial origin in the EETA79001 druse material (McDonald and Bada, 1995) suggests that this meteorite is contaminated with terrestrial organics probably derived from Antarctic ice meltwater that had percolated through the meteorite. Our data suggests that the PAHs observed in both ALH84001 and EETA79001 are derived from either the exogenous delivery of organics to Mars or extraterrestrial and terrestrial PAHs present in the ice meltwater or, more likely, from a mixture of these sources. It would appear that PAHs are not useful biomarkers in the search for extinct or extant life on Mars.  相似文献   

A search for endogenous amino acids in the Martian meteorite EETA79001     

McDonald GD  Bada JL 《Geochimica et cosmochimica acta》1995,59(6):1179-1184

The Antarctic shergottite EETA79001 is believed to be an impact-ejected fragment of the planet Mars. Samples of the carbonate (white druse) and the basaltic (lithology A) components from this meteorite have been found to contain amino acids at a level of approximately 1 ppm and 0.4 ppm, respectively. The detected amino acids consist almost exclusively of the L-enantiomers of the amino acids commonly found in proteins, and are thus terrestrial contaminants. There is no indication of the presence of alpha-aminoisobutyric acid, one of the most abundant amino acids in several carbonaceous chondrites. The relative abundances of amino acids in the druse material resemble those in Antarctic ice, suggesting that the source of the amino acids may be ice meltwater. The level of amino acids in EETA79001 druse is not by itself sufficient to account for the 600-700 ppm of volatile C reported in druse samples and suggested to be from endogenous martian organic material. However, estimates of total terrestrial organic C present in the druse material based on our amino acid analyses and the organic C content of polar ice can account for most of the reported putative organic C in EETA79001 druse.  相似文献   

热带气旋与西南低涡相互作用的两个例研究I．诊断分析   总被引：3，自引：0，他引：3       下载免费PDF全文

陈忠明  黄福均等 《大气科学》2002,26(3):352-360

通过对1989年7月8－11日西南低涡与活动于南海的强热带气旋发生远距离的相互作用的诊断分析，揭示出中低纬系统的相互作用在促进西南低涡发展和暴雨发生中所起的一些重要作用。  相似文献   

大气运动非平衡强迫与“98·7”突发性特大暴雨诊断分析   总被引：4，自引：1，他引：4  

陈忠明  徐茂良  闵文彬  高文良 《气象》2003,29(12):3-9

应用常规气象和卫星资料,对1998年7月21日发生在武汉附近地区的突发性特大暴雨过程进行了分析,结果显示(1)引发本次突发性特大暴雨的系统是一个中-β尺度对流云团.(2)该中-β尺度暴雨系统在对流层高低层没有独立的负、正涡度大值中心区与之对应,辐合层并不十分深厚(低于500hPa),且气流散合强度(10-4s-1)较旋转强度(10-5s-1)大一个量级(D＞＞ζ).(3)在暴雨发生前10余小时,大气运动已处于较强的非平衡状态,且越临近暴雨发生,U＜0的非平衡性越强;而在暴雨达到强盛期后,大气运动即由U＜0的非平衡态转为U＞0的非平衡态.(4)对流层低层大气运动非平衡动力强迫与200hPa等压面上的中-β尺度强辐散是本例暴雨和中-β尺度暴雨系统发生发展的重要动力启动机制.  相似文献   

"2001.9.18"华西突发性强暴雨的中尺度分析   总被引：2，自引：5，他引：2  

闵文彬  陈忠明  高文良  何光碧 《高原气象》2003,22(Z1):110-118

利用地面、高空和卫星观测等资料,分析了2001年9月18～20日发生在青藏高原东侧的强暴雨天气过程,揭示了暴雨的激发机制和若于中尺度特征.主要结果是(1)导致本次突发性强暴雨天气的中尺度系统是在一天内,在同一区域重复新生的2个中-β尺度对流云团.(2)边界层东南低空急流的不断加强和非地转变化对强降水天气起积极作用.(3)在强降水天气发生的每一时段,散度变化均较涡度变化对强降水天气的指示性好,前者与暴雨的关系更为密切.(4)大气运动非平衡强迫激发气流辐合增长是强降水天气的主要激发机制,未来12 h强降水发生的区域、降水强度、中心变化与非平衡强负值区变化相一致.  相似文献   

青藏高原热力作用对大气环流影响研究的综述     

华明  陈忠明 《四川气象》1997,17(4):90-93

总结了青藏高原热力作用方面的研究成果，包括冷热源的定义、表述方式、对环流和天气气候的影响，以及有关高原加热理论和模拟方面的研究进展等，并作了讨论．  相似文献   

水压致裂应力测量中破裂重张压的运用     

Rati.  JL 王建军 《地壳构造与地壳应力》1993,(3):25-30

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纵弯压扁褶皱的应变估算     

Rich.  JL 樊光明 《地质科学译丛》1993,10(1):39-40

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科学家们对玻利维亚深震机制取得了进一步的认识     

Wake.  JL 范国胜 《地壳构造与地壳应力》1995,(3):5-7

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