癌症的起源和防治          下载免费PDF全文

许靖华  Robert B. Eckhardt 《地质科学》2016,(4):1015-1039

癌细胞与正常的人体细胞不同。根据体细胞突变理论（SMT）,癌细胞是基因突变的结果。该理论还采用达尔文主义的基本原理,假设癌细胞生长是自然选择下“适者生存”的结果。与此相反,我们采用Margulis的演化理论来解释癌症的起源,并提出癌细胞由遗传而来：癌基因组起源于寄生在原核生物宿主中的细菌;在大约20亿年前的“氧气革命”期间,癌基因组与原核生物基因组因内共生作用而融合;后来宿主演化成为真核生物（原生生物、真菌、植物和动物）,每种真核生物都具有其独特的基因组;经过同样的时间间隔,原寄生细菌基因组则演化成为真核生物内的癌干细胞基因组。当前SMT假设人类基因组的突变导致癌症,但该理论无法识别编码肿瘤生长的基因组序列,也无法解释：突变为何会造成癌细胞失控性生长及复制？癌症为何是一种代谢性疾病？癌症死亡率为何与亚硝酸盐污染有关？中国用不含亚硝酸盐的公共供水源的试验为何竟可以拯救许多癌症患者的生命？SMT没能充分回答许多“神秘”的癌症问题。相反,我们提出的生物演化理论可以回答这些相关事实,包括那些SMT不能充分解释的问题。我们的理论根据是：癌基因组图谱（TCGA）的科学家未能在正常的人类基因组序列中发现突变或未突变的癌基因组。是癌基因组编码了癌细胞的生长及复制和一种不同的代谢模式。我们的理论假设,癌症起源于“休眠中”的癌干细胞因为受亚硝酸盐的影响而被激活,其中一个癌基因组编码了厌氧或缺氧的代谢模式,为癌细胞的生长及复制提供能量和生物量,其他基因组则编码了癌细胞的失控性生长及复制和其他癌症特征。亚硝酸盐以10-9 级别的浓度干扰人体正常的代谢和复制等机能。事实说明,亚硝酸盐可被定义为一种毒药。识别慢性中毒的困难可以用孟加拉国公共供水造成的砷中毒作为例证。癌症应被视为由亚硝酸盐中毒引起的疾病来进行治疗是一个假说,它可以解释为什么当中国部分地区的正常公共供水改用标准化深井水（SDWW）时,癌症死亡率可以减半。这个假说需要另一个假设来解释亚硝酸盐中毒并不影响所有饮用公共供水的人,而只影响其中一部分人。我们必须假设癌症的产生是由于干细胞,其中包括一个癌干细胞,被召唤去以修复细胞的损伤。将这些打破常规的假说放在一起,很多专家认为我们的生物演化理论是天方夜谭而不予理会。实际上,这个假说已由中国过去的SDWW实验所证实。一些医院的试验也证实,若癌症晚期患者每天饮用不含亚硝酸盐的水,癌症可以被治愈。我们对癌症晚期不可治愈这一论断提出质疑,并假定癌症是慢性亚硝酸盐中毒所致。我们呼吁其他科学家进行实验和临床试验来验证这一假说,使至少一半的晚期癌症患者,当他们的饮用水供应源不含亚硝酸盐时,可以被治愈。与此同时,我们应该将过去半个世纪以来献身医学的科学家们的成果,整合为一个“新的体系”。  相似文献   

Late quaternary sediments in Lake Zürich,Switzerland     

G. S. Lister  F. Giovanoli  G. Eberli  P. Finckh  W. Finger  Q. He  C. Heim  K. J. Hsü  K. Kelts  C. Peng  C. Sidler  X. Zhao 《Environmental Geology》1983,5(4):191-205

Lake Zürich occupies a glacially overdeepened perialpine trough in the northern Middlelands of Switzerland. A total of 154.4 m of Quaternary sediments and 47.3 m of Tertiary Molasse bedrock has been cored from the deepest part of the lake, some 10 km south of the city of Zürich. Some 16.8 m of gravels and sands directly overlying the bedrock include basal till and probably earliest subglacial fluvial and lacustrine deposits. These are overlain by 98.6 m of fine-grained, glacial-aged sediments comprising completely deformed proglacial and/or subglacial lacustrine muds, separated by four basal mud tills. The lack of interglacial sediments, fossils, and other datable material, and the presence of severe sediment deformation and unknown amounts of erosion prevent the establishment of an exact chronostratigraphy for sediments older than the upper mud till. Above it some 8.6 m of lacustrine muds were deposited, folded, faulted, and tilted during the final opening of the lake at about 17,500–17,000 years ago. Superimposed are 30.4 m of final Würm and post-glacial sediments comprising (from oldest): cyclic proglacial mud, thick-bedded and laminated mud, a complex transition zone, laminated carbonate, laminated marl, and diatom-calcite varves. These sediments reflect changing catchment and lacustrine conditions including: glacial proximity, catchment stability, lake inflow characteristics, thermal structure, chemistry, and bed stability. Average sedimentation rates ranged from 11 cm yr⁻¹ immediately after glacier withdrawal, to as low as 0.4 mm yr⁻¹ as the environment stabilized. The lack of coarse outwash deposits separating the fine-grained glaciolacustrine sediments from a corresponding underlying basal till suggests that deglaciation of the deep northern basin of Lake Zürich was by stagnation-zone retreat rather than by retreat of an active ice-front.  相似文献