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In order to elucidate the metabolic fate of 2,3,7,8-tetrachlorodibenzofuran (TCDF) in fish and to thereby facilitate the assessment of the risks posed by this environmental toxin, we determined the whole body half-life, tissue distribution and metabolism of [3H TCDF in rainbow trout (Onchorynchus mykiss), treated orally. A whole body biphasic elimination pattern resulted in the excretion of 60% of the administered chemical during the first 3 days, after which a much slower elimination-rate (half-life = 14 days) was observed. Significant amounts of water-soluble metabolites were found in both bile and liver. Of the TCDF-derived radioactivity in bile, approximately 50% represented glucuronide conjugates, predominantly 4-hydroxy-2,3,7,8-TCDF: substantial amounts of the sulfate conjugate of this same metabolite were also present. Except at early time points, muscle contained the predominant fraction of TCDF-derived radioactivity, amounting to 25–65% of the total radioactivity present in the fish. More than 95% of the radioactivity present in muscle represented unmetabolized TCDF.  相似文献   
2.
Kulak  A.  Maslanka  K.  Michalec  A.  Zieba  S. 《Studia Geophysica et Geodaetica》1999,43(4):399-406
The paper briefly reviews the preliminary results of observations of Alfvén ionospheric resonances performed in the northern Carpathian Mountains (south-eastern Poland) by the Cracow Schumann Resonances Group. The results confirm the simple models proposed recently by Lysak and Sentman.  相似文献   
3.
Dynamical systems methods are used to classify radiation-filled Friedmann world-models into those which admit of a phase transition and those which do not. A simple model of a phase transition is adopted.  相似文献   
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