Analysis of medaka cytochrome P450 3A homotropic and heterotropic cooperativity     

Kullman SW  Kashiwada S  Hinton DE 《Marine environmental research》2004,58(2-5):469-473

We have previously demonstrated that medaka CYP3A is associated with metabolism of several endobiotics including steroids and bile acids. In this study, we demonstrate that medaka CYP3A catalysis exhibits unusual kinetic behaviors consistent with allosteric interaction which cannot be described by hyperbolic kinetic models. Using 7-benzyloxy-4-(trifluoromethyl)-coumarin (BFC) and nonylphenol as CYP3A substrates, we describe both homotropic and heterotropic cooperative interactions. Given the role of CYP3A in maintaining the homeostatic balance for numerous endobiotics, enzymatic activation/inhibition by endocrine disruptors (EDCs) represents a putative (non-genomic) mechanism for endocrine disruption.  相似文献   

深海沉积物中的硫酸盐还原作用     

Canf.  DE 舒孝敬 《海洋地质译丛》1991,(6):62-67

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Biogeochemical cycles of carbon, sulfur, and free oxygen in a microbial mat   总被引：11，自引：0，他引：11  

Canfield DE  Des Marais DJ 《Geochimica et cosmochimica acta》1993,57(16):3971-3984

Complete budgets for carbon and oxygen have been constructed for cyanobacterial mats dominated by Microcoleus chthonoplastes from the evaporating ponds of a salt works located in Guerrero Negro, Baja California Sur, Mexico. Included in the budget are measured rates of O2 production, sulfate reduction, and elemental exchange across the mat/brine interface, day and night, at various temperatures and times of the year. We infer from this data the various sinks for O2, as well as the sources of carbon for primary production. To summarize, although seasonal variability exists, a major percentage of the O2 produced during the day did not diffuse out of the mat but was used within the mat to oxidize both organic carbon and the sulfide produced by sulfate reduction. At night, most of the O2 that diffused into the mat was used to oxidize sulfide, with O2 respiration of minor importance. During the day, the internal mat processes of sulfate reduction and O2 respiration generated as much or more inorganic carbon (DIC) for primary production as diffusion into the mat. Also, oxygenic photosynthesis was the most important process of carbon fixation, although anoxygenic photosynthesis may have been important at low light levels during some times of the year. At night, the DIC lost from the mat was mostly from sulfate reduction. Elemental fluxes across the mat/brine interface indicated that carbon with an oxidation state of greater than zero was taken up by the mat during the day and liberated from the mat at night. Overall, carbon with an average oxidation state of near zero accumulated in the mat. Both carbon fixation and carbon oxidation rates varied with temperature by a similar amount. These mats are thus closely coupled systems where rapid rates of photosynthesis both require and fuel rapid rates of heterotrophic carbon oxidation.  相似文献   

Sulfur isotope fractionation during bacterial sulfate reduction in organic-rich sediments   总被引：18，自引：0，他引：18  

Habicht KS  Canfield DE 《Geochimica et cosmochimica acta》1997,61(24):5351-5361

Isotope fractionation during sulfate reduction by natural populations of sulfate-reducing bacteria was investigated in the cyanobacterial microbial mats of Solar Lake, Sinai and the sediments of Logten Lagoon sulfuretum, Denmark. Fractionation was measured at different sediment depths, sulfate concentrations, and incubation temperatures. Rates of sulfate reduction varied between 0.1 and 37 micromoles cm-3 d-1, with the highest rates among the highest ever reported from natural sediments. The depletion of 34S during dissimilatory sulfate reduction ranged from 16% to 42%, with the largest 34S-depletions associated with the lowest rates of sulfate reduction and the lowest 34S-depletions with the highest rates. However, at high sulfate reduction rates (>10 micromoles cm-3 d-1) the lowest fractionation was 20% independent of the rates. Overall, there was a similarity between the fractionation obtained by the natural populations of sulfate reducers and previous measurements from pure cultures. This was somewhat surprising given the extremely high rates of sulfate reduction in the experiments. Our results are explained if we conclude that the fractionation was mainly controlled by the specific rate of sulfate reduction (mass cell-1 time-1) and not by the absolute rate (mass volume-1 time-1). Sedimentary sulfides (mainly FeS2) were on average 40% depleted in 34S compared to seawater sulfate. This amount of depletion was more than could be explained by the isotopic fractionations that we measured during bacterial sulfate reduction. Therefore, additional processes contributing to the fractionation of sulfur isotopes in the sediments are indicated. From both Solar Lake and Logten Lagoon we were able to enrich cultures of elemental sulfur-disproportionating bacteria. We suggest that isotope fractionation accompanying elemental sulfur disproportionation contributes to the 34S depletion of sedimentary sulfides at our study sites.  相似文献   

The geochemistry of river particulates from the continental USA: major elements   总被引：1，自引：0，他引：1  

Canfield DE 《Geochimica et cosmochimica acta》1997,61(16):3349-3365

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The Timing of the Palaeoproterozoic Great Oxidation Event using Dykes,Sills and Bolcanics of the Ongeluk Large Igneous Province,Kaapvaal Craton     

Ashley P. GUMSLEY  Kevin R. CHAMBERLAIN  Wouter BLEEKER  Ulf S?DERLUND  Michiel O. DE KOCK  Tobias C. KAMPMANN  Emilie R. LARSSON  Andrey BEKKER 《《地质学报》英文版》2016,90(Z1):67-68

正The Neoarchaean to Palaeoproterozoic Transvaal Supergroup of the Kaapvaal Craton,southern Africa,is one of the best-preserved and most complete stratigraphic records across a critical in juncture in the Earth’s history.  相似文献   

粘土矿物的^27AL核磁共振谱学特征     

Woes.  DE 王路长 《国外地质(北京)》1990,(3):26-32

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EFFECTS OF RIVER NETWORK WORKS AND SOIL CONSERVATION MEASURES ON RESERVOIR SILTATION     

Bruno MOLINO Rosa VIPARELLI Annamaria DE VINCENZO 《国际泥沙研究》2007,22(4):273-281

Knowledge of the morphological dynamics of a water course is essential for management of reservoir siltation. With an example of sedimentation in a reservoir in Basilicata, Italy, this paper demonstrates the effect on reservoir siltation of the hydraulic works, which are aimed to reduce sediment transport along the fluvial network and to prevent part of the sediment discharge from reaching the lake. The effect depends on the river type and on the the geological features of river basin slopes. The paper also shows how mass erosion can significantly contribute to development of reservoir siltation. Finally, preliminary results are provided about the time needed for river training works to be effective.  相似文献   

用偏振分析和波形模拟方法研究1983年纽约州古德诺地震的5次余震...     

Liu  Z 刘云生 《世界地震译丛》1993,(3):42-53

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Evolutionary Timescale of the Pulsating White Dwarf G117-B15A: The Most Stable Optical Clock Known     

Kepler SO  Mukadam A  Winget DE  Nather RE  Metcalfe TS  Reed MD  Kawaler SD  Bradley PA 《The Astrophysical journal》2000,534(2):L185-L188

We observe G117-B15A, the most precise optical clock known, to measure the rate of change of the main pulsation period of this blue-edge DAV white dwarf. Even though the obtained value is only within 1 sigma, P&d2;=&parl0;2.3+/-1.4&parr0;x10-15 s s-1, it is already constraining the evolutionary timescale of this cooling white dwarf star.  相似文献