The Japanese medaka (Oryzias latipes) model: applicability for investigating the immunosuppressive effects of the aquatic pollutant benzo[a]pyrene (BaP)     

Carlson EA  Li Y  Zelikoff JT 《Marine environmental research》2002,54(3-5):565-568

Despite the fact that BaP is a carcinogen, mammalian immunosuppressant, and ubiquitous aquatic pollutant, knowledge regarding the effects of BaP on the immune system of fish is still lacking. To begin to fill this gap, studies were conducted in medaka to examine the effects and mechanisms by which BaP exposure might alter host immunocompetence. Fish, exposed by IP injection of BaP (2-600 microg/g BW), were examined after 48 h for effects upon immune function and CYP1A expression/activity. Benzo[a]pyrene, at a concentration below that which increased levels of CYPIA expression/activity (2 microg BaP/g BW) suppressed lymphocyte proliferation. Concentrations of BaP at 20 and 200 microg/g BW. suppressed antibody-forming cell (AFC) numbers, superoxide production, and host resistance against bacteria. In contrast, exposure to the low affinity aryl hydrocarbon receptor (AhR) agonist, benzo[e]pyrene (BeP), neither induced CYP1A expression nor altered immune function. Given the lack of immunosuppressive effects produced by BeP, and the fact that exposure to the AhR antagonist (and CYP1A inhibitor) alpha-naphthoflavone (ANF) ameliorated the suppressive effects of BaP upon AFC numbers, the AhR pathway (including CYP1A-mediated production of reactive BaP metabolites) appears important in mediating BaP-induced immunotoxicity in fish, as in mammals. In the past, the medaka has proven a successful model for assessing carcinogenic agents. These studies have demonstrated its utility for also determining the immunosuppressive effects of an important aquatic contaminant.  相似文献   

动力定位系统发展状况及研究方法   总被引：21，自引：2，他引：21  

赵志高  杨建民等 《海洋工程》2002,20(1):91-97

动力定位系统（Dynamic Positioning System)是一种闭环的控制系统，其采用推力器来提供抵抗风、浪、流等作用在船上的环境力，从而使船尽可能地保持在海平面上要求的位置上，其定位成本不会随着水深增加而增加，并且操作也比较方便。本文对动力定位系统发展及各组成部分进行了介绍，以期对动力定位系统有个比较完整的认识。  相似文献   

遥感技术在地质找矿中的应用及发展前景   总被引：6，自引：0，他引：6       下载免费PDF全文

耿新霞  杨建民  张玉君  姚佛军 《地质找矿论丛》2008,23(2):89-93,139

遥感技术作为矿产勘查的一种手段应用于找矿,并取得了一定成就.遥感技术的直接应用是蚀变遥感信息的提取,遥感技术的间接应用包括地质构造信息、植被的光谱特征及矿床改造信息等方面.遥感找矿具有很大的发展前景的领域主要有:高光谱数据、数据融合技术、3S的紧密结合、计算机技术的发展.  相似文献   

分县客观定量降水预报微机自动化处理系统     

庞转棠  杨建民  魏建军  王正旺  杨艳萍 《山西气象》2002,(2):6-7

本系统着重于T106数据预报产品的应用，采用最优子集回归方程，从气象卫星网上下发的T106数值预报产品中选取最优因子，建立了长治地区11个县市24h、48h降水预报多元回归方程。该系统采用VB5编程，建立了实时资料自动处理、分县客观定量降水预报自动制作、预报结果文本、图形输出等模块。该系统可直接挂接于MICAPS系统下，定时自动运行，无需人工干预。预报结果输出图文并茂，可供预报员参考。  相似文献   

新疆东天山石英滩金矿流体包裹体地球化学   总被引：2，自引：1，他引：2  

王志良  毛景文  吴淦国  杨建民  马天林  韩春明 《地质与勘探》2003,39(2):6-10

石英滩金矿地处塔里木板块北缘阿奇山—雅满苏火山弧,容矿围岩为下二叠统阿其克布拉克组陆相火山岩,控矿构造为破火山口环形断裂。流体包裹体特征和温度等参数研究表明石英滩金矿以低温(129℃～236℃)、低盐度(1.91wt%NaCl～2.74wt%NaCl)和浅成(成矿时压力为3×106～32×106Pa,深度小于1km)为特征;流体包裹体稀土元素研究初步得出成矿流体来自中酸性岩浆和火山岩。  相似文献   

浮托安装进船过程中护舷碰撞力实测研究   总被引：2，自引：1，他引：1  

葛洪亮  李欣  杨建民  田新亮 《海洋工程》2016,34(3):19-27

浮托安装法广泛应用于大型组块海上安装。导管架平台上部组块浮托安装进船过程中,风、浪、流引起的浮托驳船横向运动造成浮托驳船与导管架桩腿的碰撞,碰撞力可能会对导管架结构造成损伤。陆丰7-2上部组块浮托安装中,为了监测碰撞力大小,设计了碰撞力海上监测系统。通过在导管架外侧四个桩腿上安装光纤光栅应变传感器对碰撞过程中导管架桩腿进行应力监测,进而计算碰撞力。对碰撞过程,载荷作用位置、方向进行简化,并对载荷大小及垂向作用位置对计算的影响进行了研究。结构分析模型简化后,测点von-Mises应力与碰撞力大小成正比,对导管架整体结构建模计算并取局部结构计算比例系数,结合应力实测数据计算出进船过程中驳船对导管架桩腿碰撞力。  相似文献   

Coupled Dynamic Response Analysis of A Multi-Column Tension-Leg-Type Floating Wind Turbine   总被引：4，自引：3，他引：1  

赵永生  杨建民  何炎平  顾敏童 《海洋工程》2016,(4):505-520

This paper presents a coupled dynamic response analysis of a multi-column tension-leg-type floating wind turbine (WindStar TLP system) under normal operation and parked conditions. Wind-only load cases, wave-only load cases and combined wind and wave load cases were analyzed separately for the WindStar TLP system to identify the dominant excitation loads. Comparisons between an NREL offshore 5-MW baseline wind turbine installed on land and the WindStar TLP system were performed. Statistics of selected response variables in specified design load cases (DLCs) were obtained and analyzed. It is found that the proposed WindStar TLP system has small dynamic responses to environmental loads and it thus has almost the same mean generator power output under operating conditions as the land-based system. The tension mooring system has a sufficient safety factor, and the minimum tendon tension is always positive in all selected DLCs. The ratio of ultimate load of the tower base fore-aft bending moment for the WindStar TLP system versus the land-based system can be as high as 1.9 in all of the DLCs considered. These results will help elucidate the dynamic characteristics of the proposed WindStar TLP system, identify the difference in load effect between it and land-based systems, and thus make relevant modifications to the initial design for the WindStar TLP system.  相似文献   

Theoretical Model and Dynamic Analysis of Soft Yoke Mooring System   总被引：2，自引：0，他引：2  

肖龙飞  杨建民  杨立军  李欣 《中国海洋工程》2008,22(2):195-204

As a popular solution for mooring an FPSO （Floating Production, Storage and Offloading） permanently in shallow water, the soft yoke mooring system has been widely used in ocean oil production activities in the Bohai Bay of China. In order to simulate the interaction mechanism and conduct dynamic analysis of the soft yoke mooring system, a theoretical model with basic dynamic equations is established. A numerical iteration algorithm based on error estimation is developed to solve the equations and calculate the dynanfic response of the mooring system due to FPSO motions. Validation is conducted by wave basin experimentation. It is shown that the numerical simulation takes only a few iteration times and the final errors are small. Furthermore, the calculated results of both the static and dynamic responses agree well with those ones obtained by the model test. It indicates that the efficiency, the precision, the reliability and the validity of the developed numerical algorithm and program are rather good. It is proposed to develop a real-time monitoring system to further monitor the dynamic performance of the FPSO with a soft yoke mooring system under various real sea environments.  相似文献   

海岸带边坡防浪林消浪理论与实验研究   总被引：5，自引：0，他引：5  

杨建民 《海洋通报》2008,27(2):16-21

在海岸边坡上种植防浪林是一种新的护岸形式,应用理论分析和模型实验对其进行了初步研究.建立波浪在斜坡上传播的控制方程及边界条件,应用摄动理论求解非线性解,得到了一阶精确解和二阶近似解.在模型实验中,确定几何比尺为 1∶10,选取桧柏树枝作为防浪林模型,根据量纲分析,确定的主要影响因素是海岸边坡坡度、波高、波周期、水深与防浪林树宽.实验结果表明,防浪林宽度与岸坡坡度对消浪效果影响较大.  相似文献   

履带式深海采矿车软底质行走性能分析     

苏强  吕海宁  杨建民  孙鹏飞 《海洋工程》2022,40(2):162-168

海底底质的物理力学参数不同于陆地土壤,其极低的抗剪强度和承压强度对深海采矿车的行走性能提出高要求。分析基于车辆地面力学理论,开展了底质土力学特性试验研究,建立了深海底质力学模型。根据深海重载作业采矿车样机结构参数,在大型动力学仿真软件Recurdyn中建立了仿真模型。通过直线行走多体动力学仿真与直线行走海试试验的对比,验证了仿真模型的准确性。在此基础上开展了采矿车样机在深海软底质上的多种行走工况动力学仿真,分析与评价其行走性能。结果表明,采矿车样机可以顺利完成转弯、爬坡、越障等基本功能。该研究成果可为深海采矿车海底行走性能评估提供理论参考,为深海采矿车和软底质的相互作用力学研究提供借鉴。  相似文献