Modelling exposure of oceanic higher trophic-level consumers to polychlorinated biphenyls: Pollution ‘hotspots’ in relation to mass mortality events of marine mammals     

Itsuki C. Handoh  Toru Kawai 《Marine pollution bulletin》2014

Marine mammals in the past mass mortality events may have been susceptible to infection because their immune systems were suppressed through the bioaccumulation of environmental pollutants such as polychlorinated biphenyls (PCBs). We compiled mortality event data sets of 33 marine mammal species, and employed a Finely-Advanced Transboundary Environmental model (FATE) to model the exposure of the global fish community to PCB congeners, in order to define critical exposure levels (CELs) of PCBs above which mass mortality events are likely to occur. Our modelling approach enabled us to describe the mass mortality events in the context of exposure of higher-trophic consumers to PCBs and to identify marine pollution ‘hotspots’ such as the Mediterranean Sea and north-western European coasts. We demonstrated that the CELs can be applied to quantify a chemical pollution Planetary Boundary, under which a safe operating space for marine mammals and humanity can exist.  相似文献   

Trends and relationships in victims’ recovery perceptions: a case study of the recovery process following the Great East Japan Earthquake     

Terumoto  Kiyomine  Tsuchiya  Yoriko  Otagiri  Rie  Nakabayashi  Hironobu  Nakabayashi  Itsuki 《Natural Hazards》2022,110(2):1061-1081

Natural Hazards - In the aftermath of a disaster, the recovery process has long-term, multi-dimensional, and interactive aspects. To clarify the recovery conditions and victims’ perceptions...  相似文献   

Pyrene induces a reduction in midbrain size and abnormal swimming behavior in early-hatched pufferfish larvae     

Yuki Sugahara  Masahumi Kawaguchi  Tatsuya Itoyama  Daisuke Kurokawa  Yasuhiko Tosa  Shin-Ichi Kitamura  Itsuki C. Handoh  Kei Nakayama  Yasunori Murakami 《Marine pollution bulletin》2014

Spills of heavy oil (HO) have an adverse effect on marine life. We have demonstrated previously that exposure to HO by fertilized eggs of the pufferfish (Takifugu rubripes) induces neural disruption and behavioral abnormality in early-hatched larvae. Here, two kinds of polycyclic aromatic hydrocarbons, pyrene and phenanthrene, were selected to examine their toxic effects on larval behavior of another pufferfish species (T. niphobles). Larvae exposed to pyrene or phenanthrene exhibited no abnormalities in morphology. However, those exposed to pyrene but not phenanthrene swam in an uncoordinated manner, although their swimming distance and speed were normal. The optic tectum, a part of the midbrain, of pyrene-exposed larvae did not grow to full size. Thus, these findings are indicated that pyrene might be a contributor to the behavioral and neuro-developmental toxicity, although there is no indication that it is the only compound participating in the toxicity of the heavy oil mixture.  相似文献   

Effects of polychlorinated biphenyls on liver function and sexual characteristics in Japanese medaka (Oryzias latipes)     

Nakayama K  Sei N  Handoh IC  Shimasaki Y  Honjo T  Oshima Y 《Marine pollution bulletin》2011,63(5-12):366-369

The effects of polychlorinated biphenyls (PCBs) on liver function and their differences between sexes were analyzed in Japanese medaka (Oryzias latipes) exposed to PCB126 or Kanechlor-400 (KC-400) using microarray. PCB exposure induced vitellogenin 1 expression in female medaka while suppressing choriogenin genes, which suggests that the effects of PCBs on estrogen-responsive genes do not occur directly through an estrogen receptor-mediated pathway. Reduction of androgen receptor alpha expression was also observed, and the gene expression pattern in PCB-exposed males changed to become more similar to that of females. Furthermore, changes in glycolysis-related genes indicate that PCB exposure might enhance glucose production via gluconeogenesis in the liver of medaka. Taken together, our results suggest that PCBs disrupt the endocrine system, especially androgen function, and may have the potential to cause demasculinizing effects. Additionally, induction of gluconeogenesis might be a response to maintain glucose levels consumed as a result of PCB exposures.  相似文献