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The hepatic mixed function oxidase system in the fish differs from that in mammals in its responses to the two classic mammalian inducers. The cytochrome P-448-type inducers (polycyclic aromatic hydrocarbons) stimulate monooxygenase activity, but phenobarbital, a P-450-type inducer, does not.1 We have compared the effects of phenobarbital (PB) and polychlorinated biphenyls (PCB) on the turnover of hepatic microsomal hemoproteins in trout (PCB's are P-448- and P-450-type inducers in mammals, which in fish induce only cytochrome P-448). We show here that neither PCB nor PB treatment changed the turnover rate. However, both the rates of synthesis and degradation were much slower than in the rat. 相似文献
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Blubber of harbour seals (Phoca vitulina) sampled from the Strait of Georgia, BC, in 1991 and 1992 contained higher concentrations of polychlorinated dibenzo-p-dioxins and furans (PCDD/F) than did samples from Quatsino Sound on western Vancouver Island. The higher proportions of 1,2,3,6,7,8-hexachlorodibenzodioxin and 2,3,7,8-tetrachlorodibenzofuran in the Strait of Georgia samples probably reflect contamination arising from the discharge of effluents from bleached kraft mills. Higher concentrations of non-ortho- and mono-ortho substituted polychlorinated biphenyls were also found in the Strait of Georgia samples, probably as a result of general industrial activity in the region. Principal components analysis showed that residues were distributed differently between males and females. Within males, concentrations of PCDD, PCDF and PCBs appeared to increase with age. Toxic equivalents (TEQ) to 2,3,7,8-tetrachlorodibenzodioxin in the Quatsino Sd. samples were close to the working guidelines for edible fish used by Health Canada; TEQ calculated for the Strait of Georgia samples exceeded these guidelines by up to a factor of five. 相似文献
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Hepatic CYP1A levels and EROD activity in English sole: biomonitoring of marine contaminants in Vancouver Harbour 总被引：4，自引：0，他引：4
To assess chemical contaminant stress in the marine environment, ethoxyresorufin-O-deethylase (EROD) activity and cytochrome P450 1A (CYP1A) expression were measured in 88 English Sole (Pleuronectes vetulus) collected during May and June 1999 from four sites in Vancouver Harbour and at an expected reference site outside the harbour. Hepatic microsomes were prepared from the fish and analyzed for total CYP content, EROD activity, and CYP1A protein levels. Hepatic EROD activity and CYP1A protein levels were elevated in fish from two sites in the inner harbour. A comparison with sediment chemistry data showed that fish with increased EROD activity and CYP1A levels came from sites containing relatively high levels of polycyclic aromatic hydrocarbons and polychlorinated biphenyls. Unexpectedly high levels of EROD activity and CYP1A protein were also found in fish from a reference site near Gibsons, in Howe Sound. The elevated EROD activity and CYP1A expression in fish from this site cannot be explained by the chemical analysis data collected. 相似文献
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R.F. Addison 《Marine pollution bulletin》1980,11(4):93-94
Dr. Addison of the Marine Ecology Laboratory at the Bedford Institute of Oceanography, Dartmouth, Nova Scotia, recently spent 3 weeks in the People's Republic of China, as a member of a Canadian delegation touring marine research facilities. His impressions of Chinese activities in the field of marine pollution follow. 相似文献
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Jonathan M. Malzone Ethan G. Sweet Addison C. Bell Gilbert L. Minzenberger 《水文研究》2020,34(4):1089-1100
Geographically isolated wetlands (GIWs) are commonly reported as having hardpan or low hydraulic conductivity units underneath that produce perched groundwater, which can sustain surface water levels independently of regional aquifer fluctuations. Despite the potential of GIW-perched aquifer systems to provide important hydrological and ecological functions such as groundwater storage and native amphibian habitat, little research has studied the hydrologic controls and dynamics of these systems. We compared several ridge-top depressional GIW-perched groundwater systems to investigate the role of watershed morphology on hydroregime and groundwater-surface water interaction. Ridge-top depressional wetlands in the Daniel Boone National Forest, Kentucky were chosen because they offer natural controls such as lack of apparent connection to surface water bodies, similar climate, and similar soils. Three wetlands with different topographic slopes and hillslope structures were mapped to distinguish key geomorphic parameters and monitored to characterize groundwater-surface water interaction. Wetlands with soil hummocks and low upland slopes transitioned from infiltration to groundwater discharge conditions in the spring and during storm events. The magnitude and duration of this transition fell along a continuum, where higher topographic slopes and steeper uplands produced comparably smaller and shorter head reversals. This demonstrates that ridge-top GIW-perched groundwater systems are largely sensitive to the runoff-recharge relationship in the upland area which can produce significant groundwater storage on a small-scale. 相似文献