Fatal attraction: synthetic musk fragrances compromise multixenobiotic defense systems in mussels     

Luckenbach T  Corsi I  Epel D 《Marine environmental research》2004,58(2-5):215-219

We studied interactions of nitromusk compounds musk ketone and musk xylene and polycyclic musks Galaxolide trade mark (HHCB), Celestolide trade mark (ADBI), Tetralide trade mark (AHTN), and Traseolide trade mark (AITI) with multixenobiotic resistance (mxr) transporters in gill tissue of the marine mussel Mytilus californianus (Conrad, 1837). A competitive substrate transport test with rhodamine B was used to assay modulation of transport activity by musks. All tested musks inhibited the transport activity in the low microm range as indicated by increased accumulation of rhodamine B in the tissue. Compared to known substrates of mxr transporters, the effective concentration range was similar to quinidine and about 100 times higher than verapamil. Musk ketone and musk xylene also inhibited efflux of rhodamine B from gill tissue which was loaded with the dye and subsequently incubated with these compounds. Synthetic musk compounds are persistent environmental pollutants in aquatic environments with a high potential to bioaccumulate. As potent inhibitors of mxr transporters they may also play a role as chemosensitizers that enable toxic mxr substrates to accumulate in cells of aquatic organisms.  相似文献   

Climate control on stacked paleosols in the Pleistocene of the Po Basin (northern Italy)     

Luigi Bruno  Michela Marchi  Ilaria Bertolini  Guido Gottardi  Alessandro Amorosi 《第四纪科学杂志》2020,35(4):559-571

Paleosols are recurrent features in alluvial successions and provide information about past sedimentary dynamics and climate change. Through sedimentological analysis on six sediment cores, the mud-dominated succession beneath the medieval ‘Two Towers’ of Bologna was investigated down to 100 m depth. A succession of weakly developed paleosols (Inceptisols) was identified. Four paleosols (P1, P2, P3 and PH) were radiocarbon-dated to 40–10 cal ka bp . Organic matter and CaCO₃ determinations indicate low groundwater levels during soil development, which spanned periods < 5 ka. The development and burial of soils, which occurred synchronously in the Bologna region and in other sectors of the Po Plain, are interpreted to reflect climatic and eustatic variations. Climatic oscillations, at the scale of the Bond cycles, controlled soil development and burial during Marine Isotope Stage (MIS) 3 (P1 and P2). Rapid sea-level oscillations probably induced soil development at the MIS 3/2 transition (P3) and favored burial of PH after 10 ka bp . Weakly developed paleosols in alluvial successions can provide clues to millennial-scale climatic and environmental variations. In particular, the paleosol-bearing succession of the Po Plain represents an unprecedent record of environmental changes across the Late Pleistocene (MIS 3 and 2) in the Mediterranean region.  相似文献   

Very deep X-ray observations of the anomalous X-ray pulsar 4U 0142+614     

N. Rea  E. Nichelli  G. L. Israel  R. Perna  T. Oosterbroek  A. N. Parmar  R. Turolla  S. Campana  L. Stella  S. Zane  L. Angelini 《Monthly notices of the Royal Astronomical Society》2007,381(1):293-300

  相似文献   

The 2005 outburst of GRO J1655−40: spectral evolution of the rise, as observed by Swift     

C. Brocksopp  K. E. McGowan  H. Krimm  O. Godet  P. Roming  K. O. Mason  N. Gehrels  M. Still  K. Page  A. Moretti  C. R. Shrader  S. Campana  J. Kennea 《Monthly notices of the Royal Astronomical Society》2006,365(4):1203-1214

We present Swift observations of the black hole X-ray transient, GRO J1655−40, during the recent outburst. With its multiwavelength capabilities and flexible scheduling, Swift is extremely well suited for monitoring the spectral evolution of such an event. GRO J1655−40 was observed on 20 occasions and data were obtained by all instruments for the majority of epochs. X-ray spectroscopy revealed spectral shapes consistent with the 'canonical' low/hard, high/soft and very high states at various epochs. The soft X-ray source (0.3–10 keV) rose from quiescence and entered the low/hard state, when an iron emission line was detected. The soft X-ray source then softened and decayed, before beginning a slow rebrightening and then spending ∼3 weeks in the very high state. The hard X-rays (14–150 keV) behaved similarly but their peaks preceded those of the soft X-rays by up to a few days; in addition, the average hard X-ray flux remained approximately constant during the slow soft X-ray rebrightening, increasing suddenly as the source entered the very high state. These observations indicate (and confirm previous suggestions) that the low/hard state is key to improving our understanding of the outburst trigger and mechanism. The optical/ultraviolet light curve behaved very differently from that of the X-rays; this might suggest that the soft X-ray light curve is actually a composite of the two known spectral components, one gradually increasing with the optical/ultraviolet emission (accretion disc) and the other following the behaviour of the hard X-rays (jet and/or corona).  相似文献   

X-ray intensity-hardness correlation and deep IR observations of the anomalous X-ray pulsar 1RXS J170849-400910     

N. Rea  G. L. Israel  T. Oosterbroek  S. Campana  S. Zane  R. Turolla  V. Testa  M. Méndez  L. Stella 《Astrophysics and Space Science》2007,308(1-4):505-511

We report here on X-ray and IR observations of the Anomalous X-ray Pulsar (AXP) 1RXS J170849-400910. First, we report on new XMM-Newton, Swift-XRT and Chandra observations of this AXP, which confirm the intensity–hardness correlation observed in the long term X-ray monitoring of this source. These new X-ray observations show that the AXP flux is rising again, and the spectrum hardening. If the increase of the source intensity is indeed connected with the glitches and a possible bursting activity, we expect this source to enter in a bursting active phase around 2006–2007. Second, we report on deep IR observations of 1RXS J170849-400910, taken with the VLT-NACO adaptive optics, showing that there are many weak sources consistent with the AXP position. Neither star A or B, as previously proposed by different authors, might yet be conclusively recognised as the IR counterpart of 1RXS J170849-400910. Third, using Monte Carlo simulations, we re-address the calculation of the significance of the absorption line found in a phase-resolved spectrum of this source, and interpreted as a resonant scattering cyclotron feature.  相似文献   

A Minimal Spanning Tree algorithm for source detection in γ-ray images     

Riccardo Campana  Enrico Massaro  Dario Gasparrini †  Sara Cutini †  Andrea Tramacere 《Monthly notices of the Royal Astronomical Society》2008,383(3):1166-1174

We developed a source detection algorithm based on the Minimal Spanning Tree (MST), that is a graph-theoretical method useful for finding clusters in a given set of points. This algorithm is applied to γ-ray bi-dimensional images where the points correspond to the arrival direction of photons, and the possible sources are associated with the regions where they clusterize. Some filters to select these clusters and to reduce the spurious detections are introduced. An empirical study of the statistical properties of MST on random fields is carried out in order to derive some criteria to estimate the best filter values. We also introduce two parameters useful to verify the goodness of candidate sources. To show how the MST algorithm works in practice, we present an application to an EGRET observation of the Virgo field, at high Galactic latitude and with a low and rather uniform background, in which several sources are detected.  相似文献   

Simultaneous identification of the pollutant release history and the source location in groundwater by means of a geostatistical approach   总被引：4，自引：1，他引：3  

Ilaria Butera  Maria Giovanna Tanda  Andrea Zanini 《Stochastic Environmental Research and Risk Assessment (SERRA)》2013,27(5):1269-1280

This paper describes an innovative procedure that is able to simultaneously identify the release history and the source location of a pollutant injection in a groundwater aquifer (simultaneous release function and source location identification, SRSI). The methodology follows a geostatistical approach: it develops starting from a data set and a reliable numerical flow and transport model of the aquifer. Observations can be concentration data detected at a given time in multiple locations or a time series of concentration measurements collected at multiple locations. The methodology requires a preliminary delineation of a probably source area and results in the identification of both the sub-area where the pollutant injection has most likely originated, and in the contaminant release history. Some weak hypotheses have to be defined about the statistical structure of the unknown release function such as the probability density function and correlation structure. Three case studies are discussed concerning two-dimensional, confined aquifers with strongly non-uniform flow fields. A transfer function approach has been adopted for the numerical definition of the sensitivity matrix and the recent step input function procedure has been successfully applied.  相似文献   

Response of single benthic metrics and multi-metric methods to anthropogenic pressure gradients, in five distinct European coastal and transitional ecosystems   总被引：4，自引：0，他引：4  

Borja A  Barbone E  Basset A  Borgersen G  Brkljacic M  Elliott M  Garmendia JM  Marques JC  Mazik K  Muxika I  Magalhães Neto J  Norling K  Rodríguez JG  Rosati I  Rygg B  Teixeira H  Trayanova A 《Marine pollution bulletin》2011,62(3):499-513

In recent times many benthic indices have been proposed to assess the ecological quality of marine waters worldwide. In this study we compared single metrics and multi-metric methods to assess coastal and transitional benthic status along human pressure gradients in five distinct environments across Europe: Varna bay and lake (Bulgaria), Lesina lagoon (Italy), Mondego estuary (Portugal), Basque coast (Spain) and Oslofjord (Norway). Hence, 13 single metrics (abundance, number of taxa, and several diversity and sensitivity indices) and eight of the most common indices used within the European Water Framework Directive (WFD) for benthic assessment were selected: index of size spectra (ISS), Benthic assessment tool (BAT), Norwegian quality index (NQI), Multivariate AMBI (M-AMBI), Benthic quality index (BQI), (Benthic ecosystem quality index (BEQI), Benthic index based on taxonomic sufficiency (BITS), and infaunal quality index (IQI). Within each system, sampling sites were ordered in an increasing pressure gradient according to a preliminary classification based on professional judgement. The different indices are largely consistent in their response to pressure gradient, except in some particular cases (i.e. BITS, in all cases, or ISS when a low number of individuals is present). Inconsistencies between indicator responses were most pronounced in transitional waters (i.e. IQI, BEQI), highlighting the difficulties of the generic application of indicators to all marine, estuarine and lagoonal environments. However, some of the single (i.e. ecological groups approach, diversity, richness) and multi-metric methods (i.e. BAT, M-AMBI, NQI) were able to detect such gradients both in transitional and coastal environments, being these multi-metric methods more consistent in the detection than single indices. This study highlights the importance of survey design and good reference conditions for some indicators. The agreement observed between different methodologies and their ability to detect quality trends across distinct environments constitutes a promising result for the implementation of the WFD’s monitoring plans. Moreover, these results have management implications, regarding the dangers of misclassification, uncertainty in the assessment, use of conflicting indices, and testing and validation of indices.  相似文献   

Deciphering late Quaternary land snail shell δO and δC from Franchthi Cave (Argolid,Greece)     

André C. Colonese  Giovanni Zanchetta  Catherine Perlès  Russell N. Drysdale  Giuseppe Manganelli  Ilaria Baneschi  Elissavet Dotsika  Hélène Valladas 《Quaternary Research》2013

This paper investigates the stable isotopic composition from late Pleistocene–Holocene (~ 13 to ~ 10.5 cal ka BP) shells of the land snail Helix figulina, from Franchthi Cave (Greece). It explores the palaeoclimatic and palaeoenvironmental implications of the isotope palaeoecology of archaeological shells at the time of human occupation of the cave. Modern shells from around the cave were also analysed and their isotopic signatures compared with those of the archaeological shells. The carbon isotope composition of modern shells depicts the consumption of C₃ vegetation. Shell oxygen isotopic values are consistent with other Mediterranean snail shells from coastal areas. Combining empirical linear regression and an evaporative model, the δ¹⁸Os suggest that modern snails in the study area are active during periods of higher relative humidity and lower rainfall δ¹⁸O, probably at night. Late glacial and early Holocene δ¹⁸Os show lower values compared to modern ones. Early Holocene δ¹⁸Os values likely track enhanced moisture and isotopic changes in the precipitation source. By contrast, lower late glacial δ¹⁸O could reflect lower temperatures and δ¹⁸Op, compared to the present day. Shell carbon isotope values indicate the presence of C₃ vegetation as main source of carbon to late glacial and early Holocene snails.  相似文献   

Background simulations for the Large Area Detector onboard LOFT     

Riccardo Campana  Marco Feroci  Ettore Del Monte  Teresa Mineo  Niels Lund  George W. Fraser 《Experimental Astronomy》2013,36(3):451-477

The Large Observatory For X-ray Timing (LOFT), currently in an assessment phase in the framework the ESA M3 Cosmic Vision programme, is an innovative medium-class mission specifically designed to answer fundamental questions about the behaviour of matter, in the very strong gravitational and magnetic fields around compact objects and in supranuclear density conditions. Having an effective area of ～10 m² at 8 keV, LOFT will be able to measure with high sensitivity very fast variability in the X-ray fluxes and spectra. A good knowledge of the in-orbit background environment is essential to assess the scientific performance of the mission and optimize the design of its main instrument, the Large Area Detector (LAD). In this paper the results of an extensive Geant-4 simulation of the instrumentwillbe discussed, showing the main contributions to the background and the design solutions for its reduction and control. Our results show that the current LOFT/LAD design is expected to meet its scientific requirement of a background rate equivalent to 10 mCrab in 2?30 keV, achieving about 5 mCrab in the most important 2–10 keV energy band. Moreover, simulations show an anticipated modulation of the background rate as small as 10 % over the orbital timescale. The intrinsic photonic origin of the largest background component also allows for an efficient modelling, supported by an in-flight active monitoring, allowing to predict systematic residuals significantly better than the requirement of 1 %, and actually meeting the 0.25 % science goal.  相似文献