Isolation,identification, and cytotoxicity of a new isobenzofuran derivative from marine <Emphasis Type="Italic">Streptomyces</Emphasis> sp. W007     

张宏宇  谢则平  娄婷婷  姜鹏 《中国海洋湖沼学报》2016,34(2):386-390

A new isobenzofuran derivative (1) was isolated from the marine Streptomyces sp. W007 and its structure was determined through extensive spectroscopic analyses, including 1D-NMR, 2D-NMR, and ESI-MS. The absolute configuration of compound 1 was determined by a combination of experimental analyses and comparison with reported data, including biogenetic reasoning, J-coupling analysis, NOESY, and ¹H-¹HCOSY. Compound 1 exhibited no cytotoxicity against human cells of gastric cancer BGC-823, lung cancer A549, and breast cancer MCF7.  相似文献