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排序方式: 共有338条查询结果,搜索用时 15 毫秒
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Boon JP van Zanden JJ Lewis WE Zegers BN Goksøyr A Arukwe A 《Marine environmental research》2002,54(3-5):719-724
The short-term effects of the commercial PBDE flame retardant mixtures Penta-BDE and cta-BDE on the expression of cytochrome P450 1A (CYP1A), vitellogenin (Vtg) and zona radiata proteins (Zrp) were investigated in juvenile salmon (Salmo salar). For this purpose, groups of fish were dosed twice (oral intake at days I and 4) with 10 and 50 mg/kg body weight of both commercial mixtures. The fishes were sacrificed at day 7 (n = 5 for each group) and 14 (n = 6 for each group), and blood, liver, fillet, and brain were collected. Blanks and positive controls were also part of the experiment. The expressions of Vtg, Zrp, and CYPIA were measured with several techniques (EROD, ELISA, Western, Northern and Slot Blot). The values in the groups of fish treated with Penta-BDE or Octa-BDE did not significantly differ from the reference group for any of the parameters tested. In contrast, the positive control groups treated with estradiol-17beta for Vtg and Zrp expression, and beta-naphthoflavone for CYP1A expression did show a significant response, indicating the potential sensitivity of the fishes for the parameters measured. Since the results of the chemical analyses showed concentrations of a number of PBDE congeners in liver, fillet, and brain that were about three orders of magnitude above those of fish from the North Sea, it is concluded that the short-term toxicity of both commercial PBDE mixtures for these endpoints was low. 相似文献
3.
Santos MM ten Hallers-Tjabbes CC Vieira N Boon JP Porte C 《Marine environmental research》2002,54(3-5):661-665
Normal and imposex-affected female Buccinum undatum were sampled from the open North Sea at three locations, one with low, and two with high shipping densities. Cytochrome P450 components and P450 aromatase activity were determined in the microsomal fractions isolated from pooled digestive gland/gonads. Cytochrome P450 aromatase activity was significantly higher (P < 0.05) in normal females collected in the low shipping density area (1,325 +/- 295 fmol/h/mg protein) than levels from imposex animals from a high shipping density area (620 +/- 287 fmol/h/mg protein). A negative correlation was found between aromatase activity and organotin body burden (r = -0.99). Levels of CYP450, cytochrome b5 and NADPH cytochrome c reductase activity did not show differences among groups. This is the first field evidence of depressed aromatase activity in imposex affected females, although additional research under laboratory controlled conditions is required to fully understand the mechanisms underlying the development of imposex in this species. 相似文献
4.
迎风有限元法在三维潮流数值模拟中的应用 总被引:4,自引:0,他引:4
为研究和开发迎风有限元法在河口海岸三维波数值模拟中的应用,并为建立三维物质扩散模型,最终为解决实际工程问题打下基础,以非线性浅水波方程为基础,采用一咱平面迎风有奶元与垂向工有限差分相结合地数值计算方法建立三维潮流数学模型,基地实际的物理过程,在计算中将三维流动分成外重力波和内重力波,耦联求解潮位和流速的空间分布。应用本模式计算了天津新港附近渤海海域的三维潮流运动,以较高的分辩率揭示了潮流空间结构特 相似文献
5.
In order to assess in fish the maternal transfer of alkylphenolic compounds to the progeny, the identification and quantification of the labelled compounds present in oocytes and embryos was conducted after dietary exposure of mature female mosquitofish to 14C-4n-nonylphenol during vitellogenesis and embryogenesis respectively. Radioactivity found in bile and liver extracts accounted for 0.9-0.6 and 0.2-0.1% of ingested radioactivity for females exposed during vitellogenesis and embryogenesis respectively. The amount of extractable radioactivity present in oocytes and embryos was 0.19 and 0.07% of the ingested dose respectively. The radio-HPLC profiles obtained from bile, liver, oocyte and embryo extracts were similar. They showed the presence of 4n-NP-glucuronide as the major metabolite and traces of unchanged 4n-NP. The other metabolites corresponded to 8-hydroxynonylphenol, 9-(4-hydroxyphenyl)-nonanoic acid and para-hydroxybenzoic acid which is the final product of the alkyl chain oxidation. Our results indicate that exposure of ovoviviparous female fish to 4-NP during vitellogenesis and embryogenesis leads to the contamination of the progeny by 4-NP and its metabolites. 相似文献
6.
"Patterns of population distribution revealed from 1989 census data are used to assess how future population movements could be affected by current political, social, and economic changes. Much migration in the USSR has reflected central planning decisions as much as the spontaneous decisions of individuals. To the extent that the influence of the command economy diminishes and a market economy emerges, major new directions of migration flows can be expected. The return of ethnic 'expatriates' to home republics can be expected to increase, as can economic migration to areas with favorably perceived economic prospects, and migration to Central and Western Europe." 相似文献
7.
Integrated chronostratigraphy of Proterozoic-Cambrian boundary beds in the western Anabar region, northern Siberia 总被引:2,自引:0,他引:2
Kaufman AJ Knoll AH Semikhatov MA Grotzinger JP Jacobsen SB Adams W 《Geological magazine》1996,133(5):509-533
Carbonate-rich sedimentary rocks of the western Anabar region, northern Siberia, preserve an exceptional record of evolutionary and biogeochemical events near the Proterozoic/Cambrian boundary. Sedimentologically, the boundary succession can be divided into three sequences representing successive episodes of late transgressive to early highstand deposition; four parasequences are recognized in the sequence corresponding lithostratigraphically to the Manykal Formation. Small shelly fossils are abundant and include many taxa that also occur in standard sections of southeastern Siberia. Despite this coincidence of faunal elements, biostratigraphic correlations between the two regions have been controversial because numerous species that first appear at or immediately above the basal Tommotian boundary in southeastern sections have first appearances scattered through more than thirty metres of section in the western Anabar. Carbon- and Sr-isotopic data on petrographically and geochemically screened samples collected at one- to two-metre intervals in a section along the Kotuikan River, favour correlation of the Staraya Reckha Formation and most of the overlying Manykai Formation with sub-Tommotian carbonates in southeastern Siberia. In contrast, isotopic data suggest that the uppermost Manykai Formation and the basal 26 m of the unconformably overlying Medvezhya Formation may have no equivalent in the southeast; they appear to provide a sedimentary and palaeontological record of an evolutionarily significant time interval represented in southeastern Siberia only by the sub-Tommotian unconformity. Correlations with radiometrically dated horizons in the Olenek and Kharaulakh regions of northern Siberia suggest that this interval lasted approximately three to six million years, during which essentially all 'basal Tommotian' small shelly fossils evolved. 相似文献
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世界应力图(WSM,World Stress Map)计划的应力指标,目前已累积数据共计10 920个,这些应力指标代表了该地区最大水平主应力的实际观测方向;与此同时,可以假定全球各个板块的绝对运动方向表征了相应各板块的最大水平主应力方向的长波分量.根据应力场的叠加原理,得到由该地区局部构造运动等因素贡献的短波分量的相对大小和方向.将全球划分成2.52.5的基本单元,对每个单元的WSM数据进行加权统计分析,得到其平均应力观测取向,利用HS2-NUVEL1全球绝对板块运动模型计算应力场的长波分量;平均观测应力取向和长波分量取向之间的夹角,决定了相应短波分量相对于观测应力场的大小及其取向的范围,并反映了特定研究地区局部应力场对总应力场的贡献程度.本文的计算结果表明,全球板块的绝大部分地区及各板块的平均效果,长波分量与短波分量对观测应力场的贡献程度相当.对于某些大陆板块内部,局部构造活动对观测应力场的贡献起到重要作用,因而控制着地震的孕育与发生. 相似文献
10.
为了确定剪胀节理的剪切强度,人们已开始运用能量原理研究岩体结构面(Ladanyi和Archambault,1970)。本项工作基于分析规则的粗糙起伏面,并且假定其是不可变形的。自然条件下的复杂岩体结构面中,很难辩认出要测量的有代表性的起伏角。Ladanyi和Archambault通过假定等价结构面的张开度和结构面的有效起伏将其成果推广到天然节理。显然,这种等量假设不是普遍适用的,而且可能导致结构面 相似文献