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江兴权 《广东海洋大学学报》1989,(Z1)
本文仿照straub离体蛙心灌流法,用浓度为10~(-6)M至10~(-3)M的拟腎上腺素药物0.05-0.25m1注入1.5m1灌流液中,观察腎上腺素、去甲腎上腺素、异丙肾上腺素、间羟胺和甲氧胺对黄鳝、乌鳢、尼罗罗非鱼、胡子鲶和埃及胡子鲶离体心脏的影响作比较,并进行心肌受体分析。实验结果表明,拟腎上腺素药物对不同种类鱼离体心脏活动的影响不同,不同种类的鱼心肌腎上腺素受体也不同。这与鱼类种属不同有关。而拟腎上腺素药物对胡子鲶和埃及胡子鲶离体心脏的影响相同:異丙腎上腺素的兴奋作用为β-受体阻断剂所抑制;甲氧胺的抑制作用为α-受体阻断剂所阻断。表明其心肌存在着β-受体和α-受体,但以β-受体的作用较明显。提示这两种同属異种鱼的心脏调节机制相同。 相似文献
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The in vitro aryl hydrocarbon receptor (AhR) agonist potency of offshore produced water effluents, collected from the United Kingdom Continental Shelf, was determined using the dioxin responsive (DR)-chemically activated luciferase expression (CALUX) assay. Octadecylsilane (C18) solid phase extraction (SPE) extracts of produced water were exposed to DR-CALUX cells for 24 h in order to investigate the contribution in potency from compounds that are stable to metabolism by the CALUX cells during exposure. The stable AhR agonist potency determined over 24 h was highly variable and ranged from 1 to 430 ng TCDD TEQCALUX l−1. These data reflect the highly variable composition of produced water discharges from different production fields. It is recommended that further work be performed to characterise the full range of stable dioxin like AhR agonists present in offshore produced water discharges using techniques such as bioassay-directed analysis. 相似文献
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Estrogen receptor (ER) agonists and androgen receptor (AR) antagonists in effluents from Norwegian North Sea oil production platforms 总被引：6，自引：0，他引：6
The in vitro estrogen receptor (ER) agonist and androgen receptor (AR) antagonist potencies of offshore produced water effluents collected from the Norwegian Sector were determined using recombinant yeast estrogen and androgen screens. Solid phase extraction (SPE) concentrates of the effluents showed E2 agonist activities similar to those previously reported for the United Kingdom (UK) Continental Shelf (<0.1-4 ng E2 L(-1)). No activity was detected in the filtered oil droplets suggesting that produced water ER activity is primarily associated with the dissolved phase. Targeted analysis for methyl- to nonyl-substituted alkylphenol isomers show the occurrence of known ER agonists in the analysed samples. For the first time, AR antagonists were detected in both the dissolved and oil associated phase at concentrations of between 20 and 8000 microg of flutamide equivalents L(-1). The identity of the AR antagonists is unknown, however this represents a significant input into the marine environment of unknown compounds that exert a known biological effect. It is recommended that further analysis using techniques such as bioassay-directed analysis is performed to identify the compounds/groups of compounds that are responsible in order to improve the assessment of the risk posed by produced water discharges to the marine environment. 相似文献
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