基于生物信息学探讨骨质疏松症与2型糖尿病的关系          下载免费PDF全文

葛殊玮  孙绍裘  彭广 《应用海洋学学报》2024,40(1):157

目的：基于生物信息学探讨骨质疏松症与 2 型糖尿病的关系。方法：通过基因表达汇编（GEO）数据库检索骨质疏松症和2型糖尿病的相关数据集,并筛选骨质疏松症-2型糖尿病共同差异表达基因,将数据导入STRING数据库找寻关键基因,以一个单细胞测序数据集作为检验集验证关键基因细胞层面的表达水平,对筛选结果进行基因本体（GO）功能及京都基因与基因组百科全书（KEGG）通路富集分析,并对关键靶点、相关中药进行频数统计及功效分类。结果：骨质疏松症与 2 型糖尿病相关通路集中在 ErbB信号通路、丝活化蛋白激酶（MAPK）信号通路、神经营养素信号通路、NOD样受体信号通路。频数统计结果显示,与骨质疏松症-2型糖尿病关键基因相关的中药有51味,以功效分类,可分为清热解毒药、止痛药、祛风药、补虚药、止呕药。结论：骨质疏松症和2型糖尿病都是复杂的代谢性疾病,涉及众多基因表达网络和信号通路。尽管两种疾病存在复杂的基因网络背景,但是分析结果表明两种疾病之间仍存在高度重合的差异基因表达和信号通路。这表明两种疾病的分子机制密切相关,可能存在共同调控的靶点,因此这些靶点可能成为药物同时干预两种疾病的治疗靶点。  相似文献   

南海北部主要经济鱼类体长与体重关系   总被引：7，自引：1，他引：7  

王雪辉  杜飞雁  邱永松 《台湾海峡》2006,25(2):262-266

文中根据1997～1999年和2001～2002年期间在南海北部底拖网调查的43种共33 389尾鱼的体长（叉长、肛长）和体重数据,应用统计分析方法对各鱼种体长与体重关系进行分析.结果表明,43种鱼分别隶属于4目16科25属,相关系数R^2的范围为0.764～0.993,相关系数R^2值相对较高,其中58%的R^2值超过0.95.幂指数b值范围为2.50～3.44,平均2.90.盒须图分析表明,50%的b值在2.79～3.01范围.经初步分析,43种主要经济鱼类中,有16种为等速生长、22种负的异速生长和5种正的异速生长.  相似文献   

Study on copper complexing ligand concentrations in several China’s coastal waters     

GONG Haidong  ZHANG Zhengbin  LIU Chunying  LIU Liansheng 《海洋学报(英文版)》2006,25(1):64-77

Copper complexing ligand concentrations in the Daya Bay, Qingdao coast, Jiaozhou Bay, South China Sea and Huanghe Estuary waters were determined by the anodic stripping voltammetry technique. The distribution regularity and the relationship with other parameters were discussed. The results were as follows: Copper complexing ligand concentrations of the South China Sea were a little higher than those of other sea areas, and they were apparently higher than those of the ocean. Compared with the subsurface layer (SSL) in the sea surface microlayer copper complexing ligand concentrations showed an enrichment phenomenon, of which the mechanism is similar to dissolved organic matter. The metal complexing ligand concentration profiles of the South China Sea showed that the value in the sea surface was the highest, then it decreased with depth accruing, and a higher value appeared at the bottom. Copper complexing ligand concentrations were higher than those of cadmium and lead. Ligands in each sea area exhibited a complicated property. In short, the distribution regularity of copper complexing ligand concentrations in China' s coastal waters was consistent with that of other regions in the world. Meanwhile, the positive relationship between the copper complexing ligand concentrations and biological oxygen demand, chemical oxygen demand, dissolved organic carbon, and viscosity were found clearly.  相似文献   

Analysis of non-linear relationships between catch per unit effort and abundance in a tuna purse-seine fishery simulated with artificial neural networks   总被引：3，自引：0，他引：3  

Gaertner  Daniel; Dreyfus-Leon  Michel 《ICES Journal of Marine Science》2004,61(5):812-820

  相似文献   

Management implications and options for a stock with unstable or uncertain dynamics: west of Scotland herring     

Simmonds  E. John; Keltz  Stephen 《ICES Journal of Marine Science》2007,64(4):679-685

  相似文献   

A thermal centroid or a mass centroid?     

Mingqiang Fang 《Journal of Oceanography》2006,62(5):759-766

This study reveals the physical backgrounds of the geometric centroid and the thermal centroid of the Western Pacific Warm Pool (WPWP) and points out their differences. The geometric centroid (actually a very close approximation to the mass centroid) anomaly of the surface WPWP correlates more closely with the Niño-3 region sea surface temperature anomaly (Niño-3 SSTA, an important indicator of El Niño/La Niña events) than the surface thermal centroid. Taking the WPWP depth (or heat storage) into account, the “real” mass or thermal centroid of the WPWP might correlate better with the El Niño/Southern Oscillation (ENSO) signals.  相似文献   

When will the eel recover? A full life-cycle model     

Astrom  Marten; Dekker  Willem 《ICES Journal of Marine Science》2007,64(7):1491-1498

  相似文献   

对虾封闭式工厂化养殖水环境要素的变化特征及其相互关系   总被引：4，自引：0，他引：4  

童万平  韦蔓新  何本茂 《台湾海峡》2004,23(1):19-23

根据2002年8月7～8日对虾工厂化养成中后期A、B代表池的实测数据，分析讨论了该时期养殖水体中环境要素的变化特征及其相互关系．结果表明：研究水体水温、盐度和溶解氧含量适宜．日变化幅度不大．但pH值略为偏低，而COD值明显偏高．与该时期投饵量大，残饵及排泄物明显增加有关．但对A池来说，生物作用的影响占主导地位，而对B池而言．则以化学过程影响为主．  相似文献   

定位卫星轨道监视系统研究     

冯真  任凌 《全球定位系统》2008,33(4):31-33

与卫星测控中心的卫星轨道参数相比,地球同步卫星定位系统中轨道计算子系统所计算出的卫星星历数据具有实时性强、精度高的特点,如何有效利用该星历数据来分析卫星轨道运行情况是该领域的一个热门研究课题。在介绍卫星轨道测定法的基础上,提出了以卫星速度变化率和卫星星下点为主要监视内容的卫星轨道监视系统,通过系统的试运行结果可以看出,该系统能够有效地监视卫星的瞬时和长期运行情况,为卫星的在轨运行管理提供了一种直观、形象的监视方法。  相似文献   

非量测数码相机（哈苏H1D型）在南极项目生产中的应用     

巩淑楠  吴善昌 《东北测绘》2008,31(1):162-164

简要分析了非量测数码相机哈苏H1D在南极中山站及拉斯曼丘陵地区所获取的影像数据的几何精度,阐明了利用该影像数据进行空中三角测量,DLG,DOM制作的技术流程及作业过程中出现问题的处理方法。  相似文献