| 制备羟基磷灰石的贝壳种类优选及方法比较 |
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| 引用本文： | 田璐琦,杨皓月,邢荣娥,刘松,李克成,于华华,李鹏程.制备羟基磷灰石的贝壳种类优选及方法比较[J].海洋科学,2024,48(3):95-102. |
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| 作者姓名： | 田璐琦 杨皓月 邢荣娥 刘松 李克成 于华华 李鹏程 |
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| 作者单位： | 中国科学院海洋研究所 实验海洋生物学重点实验室, 山东 青岛 266071;中国科学院大学, 北京 100049;中国科学院海洋研究所 实验海洋生物学重点实验室, 山东 青岛 266071;中国科学院海洋大科学研究中心, 山东 青岛 266071;中国科学院海洋研究所 实验海洋生物学重点实验室, 山东 青岛 266071;青岛海洋科学与技术国家实验室 海洋药物与生物制品功能实验室, 山东 青岛 266237;中国科学院海洋大科学研究中心, 山东 青岛 266071 |
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| 基金项目： | 国家重点研发计划项目(2019YFD0902105); 福建省科技计划项目-STS计划(2021T3013); 中国科学院海洋大科学研究中心重点部署项目(技术研发类)(COMS2020J04) |
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| 摘 要： | 本研究以CaO、煅烧后的牡蛎壳、蛤蜊壳、扇贝壳和脉红螺壳为原料, 分别采用反相微乳液法和聚乙二醇(PEG)辅助微波加热法制备了纳米羟基磷灰石(HA), 并从产物的物理化学特性以及形态学参数方面进行比较。利用傅里叶变换红外光谱、X射线衍射对各组产物进行了化学表征, 扫描电子显微镜观察样品的表面形貌, Zeta电位仪测定样品表面的电势差。结果表明, 反相微乳液法制备的HA尺寸在(104.10±1.95) nm至(207.90±3.75) nm范围内, 为近球形颗粒; 而PEG辅助微波加热法制备得到的HA尺寸在(61.17±3.11) nm与(182.70±1.05) nm范围内, 倾向于形成椭圆及棒状的颗粒, 稳定性更高, 且各组样品均表现出完全的亲水性。此外, 对比于CaO制备的HA, 以贝壳为原料制备的HA具有更好的纳米结构, 其中利用脉红螺壳制备的HA在粒径大小、稳定性以及亲水性等方面均具有优势, 并且具有更接近天然骨的钙磷比。因此脉红螺壳可以作为PEG辅助微波加热法制备羟基磷灰石的主要原料。
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| 关 键 词： | 贝壳 反相微乳液法 微波加热 聚乙二醇 羟基磷灰石 |
| 收稿时间： | 2023/3/3 0:00:00 |
| 修稿时间： | 2023/4/3 0:00:00 |
Comparison of raw materials and preparation methods for seashell hydroxyapatite |
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| TIAN Luqi,YANG Haoyue,XING Ronge,LIU Song,LI Kecheng,YU Huahu,LI Pengcheng.Comparison of raw materials and preparation methods for seashell hydroxyapatite[J].Marine Sciences,2024,48(3):95-102. |
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| Authors: | TIAN Luqi YANG Haoyue XING Ronge LIU Song LI Kecheng YU Huahu LI Pengcheng |
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| Institution: | Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China;University of Chinese Academy of Sciences, Beijing 100049, China;Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China;Marine Research Center, Chinese Academy of Sciences, Qingdao 266071, China;Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China;National Laboratory of Marine Science and Technology, Qingdao 266237, China;Marine Research Center, Chinese Academy of Sciences, Qingdao 266071, China |
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| Abstract: | In the present study, we used CaO and calcined oyster, clam, scallop, and snail shells as raw materials to synthesize nanohydroxyapatite (HA) using the reverse-phase microemulsion method and polyethylene glycol (PEG)-assisted microwave heating and compared the physicochemical characteristics and morphological parameters of HA. Fourier transform infrared spectroscopy and X-ray powder diffraction were used to characterize the product, scanning electron microscopy was employed to observe the surface morphology, and a Zeta potential analyzer was utilized for potential determination. The results showed that HA fabricated using the reverse-phase microemulsion method had a particle size between (104.10 ±1.95) and (207.90 ±3.75) nm and a sphere-like morphology; however, HA prepared using the PEG-assisted microwave method presented a smaller particle size that varied from (61.17 ±3.11) to (182.70 ±1.05) nm and tended to have an oval-like and rod-like shape, while showing better stability and hydrophilicity. In addition, compared with chemically synthesized HA, HA derived from seashells had a better nanostructure, and HA derived from snail shells outperformed others in terms of particle size, stability, and wettability. Furthermore, the Ca/P ratio of snail-shell HA was closer to that of the natural bone. Therefore, snail shells can be used as the main raw material for synthesizing HA using the PEG-assisted microwave method. |
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| Keywords: | sea shells microemulsion method microwave heating polyethylene glycol hydroxyapatite |
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