| In vitro Acute Cytotoxicity of Abamectin to the Gill Cell Line of Flounder Paralichthy olivaceus |
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| 作者姓名： | XU Yuyan GUO Huarong XIAO Qin SU Feng YIN Licheng |
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| 作者单位： | XU Yuyan，GUO Huarong，XIAO Qin，SU Feng，and YIN Licheng College of Life Science and Technology，Ocean University of China，Qingdao 266003，P. R. China |
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| 基金项目： | 清华大学校科研和教改项目 |
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| 摘 要： | The cytotoxicity of abamectin to the Gill Cell Line of Flounder (FG cell line) was examined in this study. It was found that the exposure of FG cells to abamectin caused the decreases of both cell growth rate and antioxidant enzyme activities,and the increase of intracellular O2- content. It was proposed that the reduction of antioxidant enzyme activities in FG cells caused the accu- mulation of O2- content in FG cells, leading to the change of cell morphology and even the death of cells. The results showed that FG cell line is suitable for the evaluation of the acute toxicity of abamectin.
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| 关 键 词： | 抗氧化剂 细胞毒性 生命科学 生物学 |
| 收稿时间： | 15 June 2006 |
| 修稿时间： | 2006-06-15 |
In vitro acute cytotoxicity of abamectin to the Gill Cell Line of Flounder Paralichthy olivaceus |
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| XU Yuyan GUO Huarong XIAO Qin SU Feng YIN Licheng.In vitro Acute Cytotoxicity of Abamectin to the Gill Cell Line of Flounder Paralichthy olivaceus[J].Journal of Ocean University of China,2007,6(4):369-372. |
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| Authors: | Yuyan Xu Huarong Guo Qin Xiao Feng Su Licheng Yin |
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| Institution: | College of Life Science and Technology, Ocean University of China, Qingdao 266003, P. R. China |
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| Abstract: | The cytotoxicity of abamectin to the Gill Cell Line of Flounder (FG cell line) was examined in this study. It was found that the exposure of FG cells to abamectin caused the decreases of both cell growth rate and antioxidant enzyme activities,and the increase of intracellular O2- content. It was proposed that the reduction of antioxidant enzyme activities in FG cells caused the accu- mulation of O2- content in FG cells, leading to the change of cell morphology and even the death of cells. The results showed that FG cell line is suitable for the evaluation of the acute toxicity of abamectin. |
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| Keywords: | abamectin antioxidant enzymes cell line cytotoxicity |
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