Effects on UDP glucuronosyl transferase, glutathione transferase, DT-diaphorase and glutathione reductase activities in rainbow trout liver after long-term exposure to PCB |
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| Authors: | Lars Frlin Sonja Blom Malin Celander Joachim Sturve |
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| Institution: | Lars Förlin, Sonja Blom, Malin Celander,Joachim Sturve |
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| Abstract: | In the present study, long-term exposure to PCB resulted in marked induction of the xenobiotic biotransformation enzymes UDP glucuronosyl transferase, glutathione transferase and DT-diaphorase (measured as menadione reductase and DCPIP reductase) in rainbow trout 15 or 20 weeks post-injection during the experimental period. The increase of the phase II enzymes were paralleled by a marked increase of the glutathione reductase activity. These results indicate that prolonged exposure to PCB results in increased production of organo-radicals. |
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