Mapping with Ag/Au ratios of mineralized rocks and ores as a parameter reveals that the deep fractures in the Gangdise block control the distribution of the high value regions which may represent the shallow zones of strongly mineralized areas. The variance gradient regions with large Ag/Au ratio may represent the boundaries between strongly mineralized areas and weakly mineralized areas. In the middle part of the Gangdise block, gold and silver mineralization centers mainly distribute along the NW extending Coqen-Xigaze region, NE extending Yangbajain region and E-W extending Lhasa-Gongbogyamda region. The gold and silver mineralized rocks and ores may have been slightly denuded in the west of the middle Gangdise block, and the denudation in the east, however, may be stronger. The primary gold and silver prospect in the west may be better than in the east.