Tight heterogeneous glutenite reservoir is typically not easy to form complex hydraulic fracture (HF) due to its poor physical properties, poor matrix seepage capacity, and small limit discharge radius and undeveloped natural fracture system. To improve the HF complexity and the stimulated reservoir volume (SRV), a novel stimulation technology called CO₂ miscible fracturing has been introduced and its fracturing mechanism has been studied. The CO₂ miscible fracturing modifies the in situ stress field by injecting low viscosity fluid to increase the HF complexity and SRV. Therefore, a series of numerical simulations based on a hydro-mechanical-damage model were carried out to study the effects of low viscosity fluid pre-injection on pore pressure, stress field, and fracturing effect in tight heterogeneous glutenite reservoirs. The results indicate that the low viscosity fluid injection can effectively increase the pore pressure around the wellbore and reduce the effective stress of the glutenite. The FCI and SRV increase with the increase of the pre-injection amount of the low viscosity fluid. The HF complexity and SRV can be improved by pre-injecting low viscosity fluid to transform the in situ stress field. The field application of this technology in a well of Shengli Oilfield showed that low-viscosity fluid pre-injection can effectively increase the width of the fractured zone, improve the SRV, and optimize the fracturing effect.