| 应用BOLD进行核磁脑功能成像的误区：神经元活动时脑血氧变化的多样性 |
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| 引用本文： | 酒谷,薰博士,Chikashi Fukaya.应用BOLD进行核磁脑功能成像的误区：神经元活动时脑血氧变化的多样性[J].CT理论与应用研究,2000,9(Z1):125-126. |
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| 作者姓名： | 酒谷 薰博士 Chikashi Fukaya |
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| 作者单位： | Department of Neurosurgery, China-Japan Friendship Hospital, China;Department of Neurosurgery, Nihon University School of Medicine, Japan,Department of Neurosurgery, Nihon University School of Medicine, Japan |
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| 摘 要： | Functional MRI (fMRI) is recognized as a well-established non-invasive diagnostic method to image activating cortical areas. Currently, the blood oxygenation level dependent (BOLD) contrast method is widely used in fMRI. BOLD-fMRI images activating are as by detecting a reduced concentration of deoxyhemoglobin during neuronal activity, which is caused by a larger increase in O2 delivery compared with O2 consumption in normal adults. In the present study, near infrared spectroscopy, which is an optical method to evaluate cerebral blood oxygenation changes, has demonstrated an increase of deoxyhcmoglobin associated with increases of oxyhemoglobin and total hemoglobin at activation areas of stroke patients, whereas BOLD-fMRI failed to image the activation areas. The present findings have serious implications for the appiication of BOLD-fMRI to the patients with brain disorders because BOLD-fMRI may overlook neuronal activities in these patients unless both increases and decreases of signals are considered.
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Pitfalls of brain functional mapping using BOLD functional MRI: multiplicity of cerebral blood oxygenation changes during neuronal activities |
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| Kaoru Sakatani,Yoichi Katayama,Yoshihiro Murata,Chikashi Fukaya.Pitfalls of brain functional mapping using BOLD functional MRI: multiplicity of cerebral blood oxygenation changes during neuronal activities[J].Computerized Tomography Theory and Applications,2000,9(Z1):125-126. |
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| Authors: | Kaoru Sakatani Yoichi Katayama Yoshihiro Murata Chikashi Fukaya |
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| Abstract: | Functional MRI (fMRI) is recognized as a well-established non-invasive diagnostic method to image activating cortical areas. Currently, the blood oxygenation level dependent (BOLD) contrast method is widely used in fMRI. BOLD-fMRI images activating are as by detecting a reduced concentration of deoxyhemoglobin during neuronal activity, which is caused by a larger increase in O2 delivery compared with O2 consumption in normal adults. In the present study, near infrared spectroscopy, which is an optical method to evaluate cerebral blood oxygenation changes, has demonstrated an increase of deoxyhcmoglobin associated with increases of oxyhemoglobin and total hemoglobin at activation areas of stroke patients, whereas BOLD-fMRI failed to image the activation areas. The present findings have serious implications for the appiication of BOLD-fMRI to the patients with brain disorders because BOLD-fMRI may overlook neuronal activities in these patients unless both increases and decreases of signals are considered. |
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